Clopidogrel (SR-25990C) Bisulfate

Catalog No.S1415 Batch:S141505

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Technical Data

Formula

C16H16ClNO2S.H2SO4
Molecular Weight 419.9 CAS No. 120202-66-6
Solubility (25°C)* In vitro DMSO 84 mg/mL (200.04 mM)
Ethanol 84 mg/mL (200.04 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
5.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
Clear solution
5% DMSO 95% corn oil
1.25mg/ml Taking the 1 mL working solution as an example, add 50 μL of 25 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Clopidogrel (SR-25990C) Bisulfate is an oral, thienopyridine class antiplatelet agent.
Targets
P2Y12 [1]
In vitro Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes. [1] Clopidogrel (1 μM) also inhibits EGF-stimulated EGF receptor, PERK expression, and cell proliferation in RGM-1 cells (P<0.05), and causes much less inhibition of EGF-stimulated cell proliferation in EGF receptor over-expressed RGM-1 cells than in RGM-1 cells (22% vs. 32% reduction). [2] Clopidogrel increases blood vessel number, reduces polymorphonuclear count and decreases attachment and bone loss, also decreases osteoclast number in rats submitted or not to periodontal repair. Clopidogrel decreases CXCL4, CXCL12 and PDGF content compared with saline-treated rats, without affecting CXCL5. [3]
In vivo Clopidogrel (2mg and 10mg/kg/day) significantly decreases ulcer-induced gastric epithelial cell proliferation and ulcer-stimulated expressions of EGF receptor and phosphorylated extracellular signal-regulated kinase (PERK) at the ulcer margin of rats. [2] Clopidogrel improves endothelial function and NO bioavailability in rats with congestive heart failure. Clopidogrel-treated Congestive heart failure (CHF) rat displays enhances phosphorylation of AKT and eNOS. [4] The clopidogrel/aspirin combination shows only additive-type effects on bleeding time prolongation induced by ear transection in the rabbit, therefore showing that combined inhibition of cyclooxygenase and ADP's effects provide a marked enhanced antithrombotic efficacy. [5]

Protocol (from reference)

Customer Product Validation

, , Cell, 2018, 172(3):564-577.e13

Data from [Data independently produced by , , Mol Carcinog, 2018, 57(12):1690-1697]

Selleck's Clopidogrel (SR-25990C) Bisulfate has been cited by 8 publications

Clopidogrel Administration Impairs Post-Stroke Learning and Memory Recovery in Mice [ Int J Mol Sci, 2023, 24(14)11706] PubMed: 37511466
P2Y12 inhibitor clopidogrel inhibits renal fibrosis by blocking macrophage-to-myofibroblast transition [ Mol Ther, 2022, S1525-0016(22)00420-8] PubMed: 35791881
XJ-8, a natural compound isolated from Sanguis draxonis, inhibits platelet function and thrombosis by targeting MAP3K3 [ J Thromb Haemost, 2021, 10.1111/jth.15593] PubMed: 34780114
Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures [ Cell Rep, 2020, 33(5):108346] PubMed: 33147450
Towards the Therapeutic Use of TSP-1 (Thrombospondin-1)/CD47 Targeting TAX2 Peptide as an Antithrombotic Agent [ Arterioscler Thromb Vasc Biol, 2020, ATVBAHA120314571] PubMed: 33232198
P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine. [ J Neuroinflammation, 2019, 16(1):217] PubMed: 31722730
FBLIM1 enhances oral cancer malignancy via modulation of the epidermal growth factor receptor pathway [Toeda Y Mol Carcinog, 2018, 57(12):1690-1697] PubMed: 30129678
Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune Disease. [Pagan JD, et al. Cell, 2017, S0092-8674(17)31431-9] PubMed: 29275858

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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