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Technical Data
| Formula | C62H111N11O12 |
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| Molecular Weight | 1202.61 | CAS No. | 79217-60-0 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (83.15 mM) | |
| Ethanol | 100 mg/mL (83.15 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. | |
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| In vitro | Cyclosporine induces phenotypic changes, including invasiveness of non-transformed cells, by a cell-autonomous mechanism. Cyclosporine treatment of adenocarcinoma cells results in striking morphological alterations, including membrane ruffling and numerous pseudopodial protrusions, increased cell motility, and anchorage-independent (invasive) growth. [1] Cyclosporine (cyclosporin A, CsA) has potent immunosuppressive properties, reflecting its ability to block the transcription of cytokine genes in activated T cells. Cyclosporine through formation of a complex with cyclophilin inhibits the phosphatase activity of calcineurin, which regulates nuclear translocation and subsequent activation of NFAT transcription factors. Cyclosporine also blocks the activation of JNK and p38 signaling pathways triggered by antigen recognition, making CsA a highly specific inhibitor of T cell activation. [2] Cyclosporine-mediated inhibition of the biliary excretion of MPAG by the Mrp2 transporter is the mechanism responsible for the interaction between Cyclosporine and mycophenolate mofetil (MMF). [3] Cyclosporine inhibits biochemical and morphological differentiation of skeletal muscle cells while having a minimal effect on proliferation. [4] | |
| In vivo | Cyclosporine enhances tumour growth in immunodeficient SCID-beige mice. [1] Cyclosporine inhibits muscle regeneration after induced trauma in mice. [4] Cyclosporine peaks at 1 hour in blood, spleen, and kidney, with higher concentrations in spleen and kidney than in blood. [5] |
Protocol (from reference)
References
Selleck's Cyclosporine has been cited by 13 publications
| ATP/IL-33-Co-Sensing by Mast Cells (MCs) Requires Activated c-Kit to Ensure Effective Cytokine Responses [ Cells, 2023, 12(23)2696] | PubMed: 38067124 |
| Masitinib Inhibits Hepatitis A Virus Replication [ Int J Mol Sci, 2023, 24(11)9708] | PubMed: 37298659 |
| Bacterial infection reinforces host metabolic flux from arginine to spermine for NLRP3 inflammasome evasion [ Cell Rep, 2021, 34(10):108832] | PubMed: 33691113 |
| Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis [ Eur J Pharmacol, 2021, 898:173999] | PubMed: 33675785 |
| Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating. [ Nat Microbiol, 2019, 4(11):1840-1850] | PubMed: 31611641 |
| Inhibition of MDR1 overcomes resistance to brentuximab vedotin in Hodgkin lymphoma. [ Clin Cancer Res, 2019, clincanres.1768.2019] | PubMed: 31811017 |
| A targeted genomic alteration analysis predicts survival of melanoma patients under BRAF inhibitors [ Oncotarget, 2019, 10(18):1669-1687] | PubMed: 30899440 |
| Topical application of phenytoin or nifedipine-loaded PLGA microspheres promotes periodontal regeneration in vivo. [ Arch Oral Biol, 2019, 97:42-51] | PubMed: 30342306 |
| [ Theranostics, 2018, ] | PubMed: 30083255 |
| Polydopamine-coated Au-Ag nanoparticle-guided photothermal colorectal cancer therapy through multiple cell death pathways [Hao M Acta Biomater, 2018, 83:414-424] | PubMed: 30366131 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.