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Technical Data
| Formula | C23H36N2O2 |
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| Molecular Weight | 372.54 | CAS No. | 98319-26-7 | |
| Solubility (25°C)* | In vitro | DMSO | 75 mg/mL (201.32 mM) | |
| Ethanol | 75 mg/mL (201.32 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Finasteride (MK-906) is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB). | ||
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| Targets |
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| In vitro | Finasteride binds to the type 2 isozyme-NADPH complex to form a ternary complex with Ki of 1.19 nM, which then rearranges to a high affinity complex (E:I) with a pseudo first order rate constant of 1.62 ms. [1] Finasteride dose-dependently inhibits the growth rate of the LnCap cell line. [2] Finasteride markedly inhibits prostate-specific antigen (PSA) secretion and expression in LNCaP cells. [3] | ||
| In vivo | Finasteride induces dosage-related incidences of hypospadias (penischisis) in male offspring with a threshold dosage level near 0.1 mg/kg/day and a 100% effect level of 100 mg/kg/day in male rats. Finasteride also causes decreased anogenital distance in male offspring in male rats. [4] Finasteride and castration decreases prostate weight at day 21 by 65% and 93%, respectively, in rats. Finasteride has no significant effect on DNA content after 4 days and decreases DNA content by a maximum of 52% at 14 days in rats. Finasteride causes a less intense increase in staining in which 16% of epithelial cells stained for tissue transglutaminase on day 9 with a return to baseline by day 14 in rats. Finasteride-induced staining is less intense with peak staining at day 4 (0.7% of epithelial cells) and a return to control values by day 9 in rats. [5] |
Protocol (from reference)
References
Selleck's Finasteride has been cited by 6 publications
| Rate of castration-induced prostate stroma regression is reduced in a mouse model of benign prostatic hyperplasia [ Am J Clin Exp Urol, 2023, 11(1):12-26] | PubMed: 36923722 |
| Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men [ Cell Stem Cell, 2020, 27(6):876-889.e12] | PubMed: 33232663 |
| Mechanical stretch enhances sex steroidogenesis in C2C12 skeletal muscle cells. [ Steroids, 2019, 150:108434] | PubMed: 31278919 |
| [ Cell Death Dis, 2018, ] | PubMed: 29568063 |
| Imaging prostate cancer (PCa) with [99m Tc(CO)3 ]finasteride dithiocarbamate [Shah SQ, et al. J Labelled Comp Radiopharm, 2018, 61(7):550-556] | PubMed: 29532957 |
| Finasteride Enhances the Generation of Human Myeloid-Derived Suppressor Cells by Up-Regulating the COX2/PGE2 Pathway. [ PLoS One, 2016, 11(6):e0156549] | PubMed: 27253400 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.