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Technical Data
| Formula | C4H7NaO2 |
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| Molecular Weight | 110.09 | CAS No. | 156-54-7 | |
| Solubility (25°C)* | In vitro | Water | 22 mg/mL (199.83 mM) | |
| Ethanol | 22 mg/mL (199.83 mM) | |||
| DMSO | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). Sodium butyrate (NaB) inhibits cell cycle progression, promotes differentiation, and induces apoptosis and autophagy in several types of cancer cells. | |
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| In vitro | Butyrate mediates growth inhibition of colonic cancer cells and thereby to elucidate the molecular link between a high-fiber diet and the arrest of colon carcinogenesis. Butyrate induces p21 mRNA expression in an immediate-early fashion, through transactivation of a promoter cis-element(s) located within 1.4 kb of the transcriptional start site, independent of p53 binding. [1] Sodium butyrate, at physiological concentrations, induces apoptosis in 2 adenoma cell lines, RG/C2 and AA/Cl, and in the carcinoma cell line PC/JW/FI. [2] Butyrate exerts potent effects on a variety of colonic mucosal functions such as inhibition of inflammation and carcinogenesis, reinforcing various components of the colonic defence barrier and decreasing oxidative stress. [3] Butyrate inhibits most HDAC except class III HDAC and class II HDAC6 and -10. Butyrate also is the most effective fatty acid in stimulating or repressing the expression of specific genes. [4] | |
| In vivo | Sodium butyrate significantly extends survival in a dose-dependent manner, improves body weight and motor performance, and delays the neuropathological sequelae in the R6/2 transgenic mouse model of Huntington's disease (HD). Sodium butyrate also increases histone and specificity protein-1 acetylation and protects against 3-nitropropionic acid neurotoxicity. [5] |
Protocol (from reference)
References
Customer Product Validation
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Data from [PLoS Biol, 2014, 12(1), e1001758]
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Data from [Data independently produced by Br J Haematol, 2014, 167(5), 639-50]
Selleck's Sodium butyrate has been cited by 26 publications
| Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation [ J Clin Invest, 2023, 133(18)e166490] | PubMed: 37712417 |
| Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation [ J Clin Invest, 2023, 133(18)e166490] | PubMed: 37712417 |
| Regulation of Hsa-miR-4639-5p expression and its potential role in the pathogenesis of Parkinson's disease [ Aging Cell, 2023, 22(6):e13840] | PubMed: 37101349 |
| Synergistic effect of sodium butyrate and oxaliplatin on colorectal cancer [ Transl Oncol, 2023, 27:101598] | PubMed: 36512976 |
| HDAC-Specific Inhibitors Induce the Release of Porcine Epidemic Diarrhea Virus via the COPII-Coated Vesicles [ Viruses, 2023, 15(9)1874] | PubMed: 37766280 |
| Zearalenone disturbs the reproductive-immune axis in pigs: the role of gut microbial metabolites [ Microbiome, 2022, 10(1):234] | PubMed: 36536466 |
| Pathogen size alters C-type lectin receptor signaling in dendritic cells to influence CD4 Th9 cell differentiation [ J Exp Clin Cancer Res, 2022, 41(1):111] | PubMed: 35346324 |
| Butyrate Lowers Cellular Cholesterol through HDAC Inhibition and Impaired SREBP-2 Signalling [ Int J Mol Sci, 2022, 23(24)15506] | PubMed: 36555149 |
| Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules [ Int J Mol Sci, 2022, 23(8)4213] | PubMed: 35457029 |
| AP-1 activity is a major barrier of human somatic cell reprogramming [ Cell Mol Life Sci, 2021, 10.1007/s00018-021-03883-x] | PubMed: 34181046 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.