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Technical Data
| Formula | C16H21Cl2N3O2
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| Molecular Weight | 358.26 | CAS No. | 16506-27-7 | |
| Solubility (25°C)* | In vitro | DMSO | 72 mg/mL (200.97 mM) | |
| Ethanol | 7 mg/mL (19.53 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Bendamustine is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma. |
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Protocol (from reference)
Selleck's Bendamustine has been cited by 12 publications
| Anti-tumor activity of selinexor in combination with antineoplastic agents in chronic lymphocytic leukemia [ Sci Rep, 2023, 13(1):16950] | PubMed: 37805613 |
| Anti-tumor activity of selinexor in combination with antineoplastic agents in chronic lymphocytic leukemia [ Sci Rep, 2023, 13(1):16950] | PubMed: 37805613 |
| The potential efficacy and mechanism of bendamustine in entra-nodal NK/T cell lymphoma [ Hematol Oncol, 2022, 10.1002/hon.3007] | PubMed: 35439335 |
| Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-β-catenin-STAT3 signaling [ Cell Death Differ, 2021, 10.1038/s41418-021-00880-2] | PubMed: 34743203 |
| Study of the antilymphoma activity of pracinostat reveals different sensitivities of DLBCL cells to HDAC inhibitors [ Blood Adv, 2021, 5(10):2467-2480] | PubMed: 33999145 |
| Regulatory Dendritic Cells Induced by Bendamustine Are Associated With Enhanced Flt3 Expression and Alloreactive T-Cell Death [ Front Immunol, 2021, 12:699128] | PubMed: 34249005 |
| Novel Peptide-drug Conjugate Melflufen Efficiently Eradicates Bortezomib-resistant Multiple Myeloma Cells Including Tumor-initiating Myeloma Progenitor Cells [ Hemasphere, 2021, 5(7):e602] | PubMed: 34136753 |
| Obinutuzumab in Combination with Chemotherapy Enhances Direct Cell Death in CD20-Positive Obinutuzumab-resistant Non-Hodgkin Lymphoma Cells [ Mol Cancer Ther, 2021, 10.1158/1535-7163.MCT-20-0864] | PubMed: 33850006 |
| Bendamustine Conditioning Skews Murine Host DCs Toward Pre-cDC1s and Reduces GvHD Independently of Batf3 [ Front Immunol, 2020, 11:1410] | PubMed: 32765499 |
| Supernumerary Incisors in CB6F1 Mice Conditioned with Chemotherapy and Total Body Irradiation before Bone Marrow Transplantation [ Comp Med, 2018, 68(5):349-352] | PubMed: 30208992 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.