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Technical Data
| Formula | C18H32CaN2O10 |
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| Molecular Weight | 476.53 | CAS No. | 137-08-6 | |
| Solubility (25°C)* | In vitro | DMSO | 44 mg/mL (92.33 mM) | |
| Water | 44 mg/mL (92.33 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Calcium D-Panthotenate (D-Pantothenic Acid Calcium), also called vitamin B5 Calcium, is a water-soluble vitamin and an essential nutrient for many animals. |
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| In vitro | Pantothenic acid increases mainly the content of free glutathione, with little effect on protein-boundglutathione in human lymphoblastoic (Jurkat) cells. Pantothenic acid also increases cell respiration with pyruvate as the exogenous substrate.[1] Pantothenic acid belongs to vitamin B group and is the building stone of coenzyme A. Pantothenic acid can be therefore infer that its beneficial effect in various kinds of cell damage by ROS is related to the increased content or stimulated biosynthesis of this coenzyme. Pantothenic acid increases the glutathione content by more than 50% and increases the GSH/GSSG ratio by approximately the same factor. [2] Pantothenic acid and N-acetylcysteine alleviates the ultraviolet-induced decrease of glutathione content, diminished lipid peroxidation, and partly protects the cells against apoptosisproduced by ultraviolet irradiation. [3] |
| In vivo | Pantothenic acid-treated rats exhibited higher basal levels of corticosterone and progesterone than control rats in Adrenal cells. The response of ACTH and/or PRL on corticosterone and progesterone release is higher in the pantothenic acid-treated rats than in the control rats. Pantothenic acid supplementation stimulates the ability of adrenal cells in male rats to secrete corticosterone and progesterone. Pantothenic acid supplementation induces adrenalhyperresponsiveness to ACTH stimulation, and PRL further stimulated adrenal sensitivity to ACTH. [4] Pantothenic acid prior to valproic acid (VPA) significantly protects against VPA-induced neural tube defects (NTDs) in CD-1mice. Pantothenic acid prevents VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb in CD-1 mice. [5] |
Protocol (from reference)
References
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.