|
Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. |
Technical Data
| Formula | C7H7ClO |
|||
| Molecular Weight | 142.58 | CAS No. | 59-50-7 | |
| Solubility (25°C)* | In vitro | DMSO | 29 mg/mL (203.39 mM) | |
| Ethanol | 29 mg/mL (203.39 mM) | |||
| Water | Insoluble | |||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
||||
Preparing Stock Solutions
Biological Activity
| Description | Chlorocresol(4-Chloro-3-methylphenol,PCMC) is an activator of ryanodine receptor.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. | |
|---|---|---|
| Targets |
|
|
| In vitro | Chlorocresol (1 mM) is capable of releasing Ca2+ from a ruthenium red/caffeine-sensitive Ca2+ release channel selectively localized in terminal cistemae (TC), whereas Chlorocresol has no effect on longitudinal sarcoplasmic reticulum (LSR), indicating that Chlorocresol is not acting by inhibiting the Ca2+-ATPase or damaging the vesicles. Chlorocresol is capable of releasing Ca2+ from heparmn-treated cerebellar microsomes. In PC12 cells, Chlorocresol releases Ca2+ from a caffeine/thapsigargin- sensitive intracellular store. The chloro and methyl groups in Chlorocresols are important for the activation of the ryanodine receptor Ca2+ release channel. [1] Chlorocresol causes muscle contracture in malignant hyperthermia-susceptible (MHS) muscles at a concentration of 25–50 mM and potentiates the caffeine contracture response in human MHS muscles. Sub-threshold (20 mM) concentrations of Chlorocresol increases both the Kd (6.0 vs. 10 mM) and the Vmax (2.2 vs. 1.55 mmol Ca2+/min/mg protein) of caffeine-induced Ca2+ release from isolated rabbit terminal cisternae. [2] |
Protocol (from reference)
References
|
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.