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Technical Data
| Formula | C22H30FO8P.2Na |
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| Molecular Weight | 516.4 | CAS No. | 55203-24-2 | |
| Solubility (25°C)* | In vitro | Water | 100 mg/mL (193.64 mM) | |
| DMSO | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. | ||
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| In vitro | Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. [1] Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. [2]Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. [3] Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression. [5] | ||
| In vivo | Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. [4] Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats. [5] | ||
| Features | Great selectivity for COX-2. |
Protocol (from reference)
| Animal Study:[5] |
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References
Customer Product Validation
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Data from [Oncogene, 2013, 32, 1316-29]
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Data from [Oncogene, 2013, 32, 1316-29]
Selleck's Dexamethasone Sodium Phosphate has been cited by 30 publications
| Enhanced Differentiation Capacity and Transplantation Efficacy of Insulin-Producing Cell Clusters from Human iPSCs Using Permeable Nanofibrous Microwell-Arrayed Membrane for Diabetes Treatment [ Pharmaceutics, 2022, 14(2)400] | PubMed: 35214135 |
| Dexamethasone Sensitizes Acute Monocytic Leukemia Cells to Ara-C by Upregulating FKBP51 [ Front Oncol, 2022, 12:888695] | PubMed: 35860568 |
| Ponatinib sensitizes myeloma cells to MEK inhibition in the high-risk VQ model [ Sci Rep, 2022, 12(1):10616] | PubMed: 35739276 |
| Establishing a clinically relevant orthotopic xenograft model of patient-derived glioblastoma in zebrafish [ Dis Model Mech, 2022, dmm.049109] | PubMed: 35199829 |
| PON2 blockade overcomes dexamethasone resistance in acute lymphoblastic leukemia [ Hematology, 2022, 27(1):32-42] | PubMed: 34957927 |
| CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma [ Mol Cancer, 2021, 20(1):84] | PubMed: 34090465 |
| A universal gene correction approach for FKRP-associated dystroglycanopathies to enable autologous cell therapy [ Cell Rep, 2021, 36(2):109360] | PubMed: 34260922 |
| Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression [ JCI Insight, 2021, 6(19)e147038] | PubMed: 34622799 |
| Comprehensive CRISPR-Cas9 screens identify genetic determinants of drug responsiveness in multiple myeloma [ Blood Adv, 2021, 5(9):2391-2402] | PubMed: 33950175 |
| Resveratrol attenuates dapagliflozin-induced renal gluconeogenesis via activating the PI3K/Akt pathway and suppressing the FoxO1 pathway in type 2 diabetes [ Food Funct, 2021, 10.1039/d0fo02387f] | PubMed: 33432947 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.