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Technical Data
| Formula | C14H15N7.2C4H7NO3 |
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| Molecular Weight | 515.52 | CAS No. | 908-54-3 | |
| Solubility (25°C)* | In vitro | Water | 103 mg/mL (199.79 mM) | |
| DMSO | 19 mg/mL (36.85 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Diminazene(Diminazene diaceturate) is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties. |
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| In vitro | Diminazene is capable of inhibiting the P2 transporter activity and this activity is lost in one diminazene-adapted trypanosome line, this does not formally prove that TbAT1 transports diminazene, nor does it establish whether transporter in addition to P2 could be involved in diminazene uptake. Diminazene is rapidly accumulated through a single transporter in T. brucei brucei 427 with Km value of 0.45 μM. [3H]Diminazene transport is also potently inhibited by pentamidine and adenosine, with Ki values of 0.21 μM and 0.25 μM, respectively. [3H]diminazene (2.5 μM) is clearly accumulated by yeast cells expressing TbAT1, with a rate of 0.0083 pmol/107 cell/s, and this process is completely inhibited by the presence of 1 mM unlabeled diminazene aceturate. [1] |
| In vivo | Diminazene aceturate (3.5 mg/kg) appeares to be effective in the first treatment of horses and mules infected with T. evansi, parasites are cleared from the peripheral blood of horses on days 1 and 7 and mules on days 1 and 14. [2] Diminazene aceturate (DA) (7 mg/kg, i.m.) effectively clears the parasites from the blood of the infected treated dogs. [3] |
Protocol (from reference)
References
Selleck's Diminazene Aceturate has been cited by 4 publications
| Identification and targeting of microbial putrescine acetylation in bloodstream infections [ bioRxiv, 2023, 2023.09.21.558834] | PubMed: 37790300 |
| Identification and targeting of microbial putrescine acetylation in bloodstream infections [ bioRxiv, 2023, 10.1101/2023.09.21.558834] | PubMed: 37790300 |
| Lactate Dehydrogenase as a Potential Therapeutic Drug Target to Control Babesia bigemina [ Front Cell Infect Microbiol, 2022, 12:870852] | PubMed: 35521220 |
| Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways. [ Am J Physiol Lung Cell Mol Physiol, 2020, 10.1152/ajplung.00025.2020] | PubMed: 32160007 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.