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Technical Data
| Formula | C13H20N2O2 |
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| Molecular Weight | 236.31 | CAS No. | 17692-31-8 | |
| Solubility (25°C)* | In vitro | DMSO | 47 mg/mL (198.89 mM) | |
| Ethanol | 47 mg/mL (198.89 mM) | |||
| Water | 11 mg/mL (46.54 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Dropropizine (UCB-1967,(±)- Dropropizine) is a racemic non-opiate antitussive agent, it is used as a cough suppressant. |
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| In vitro | Dropropizine shows neither mutagenic nor clastogenic effects in Chinese hamster V79 and human EUE cells, while Lithium carbonicum manifestes a weak and mazindol a medium genotoxic response which is in both cases reduce in the presence of microsomal fraction S9. [1] |
| In vivo | Dropropizine exhibits antitussive activity in cats noticeably lower than Pinacidil and Codeine. [2] Dropropizine (100 mg/kg, b.w., intraperitoneally) has similar antitussive activity as that of EEPF (200 mg/kg, b.w., orally). [3] Dropropizine exhibits antitussive activity of 28.3% in mechanically induced cough in nonanaesthetized cats, comparable to prenoxdiazine (24.7%).[4] Dropropizine (dropro–dose 100 mg/kg b.w.) exhibits comparable cough-suppressing effect of mucilage from S. althaeae. Dropropizine (dropro–dose 100 mg/kg b.w.) exhibits antitussive activity less than E. officinalis on the mechanically induced cough reflex under experimental conditions. [5] |
Protocol (from reference)
References
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.