Eflornithine (DFMO) hydrochloride hydrate

Catalog No.S4582 Batch:S458204

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Technical Data

Formula

C6H12F2N2O2.HCl.H2O
Molecular Weight 236.64 CAS No. 96020-91-6
Solubility (25°C)* In vitro Water 47 mg/mL (198.61 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Eflornithine (DFMO) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.
Targets
Orn decarboxylase [2]
In vitro

When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur[1].
In vivo

Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    BY2 cell

  • Concentrations

    2 mM

  • Incubation Time

    48 h

  • Method

    BY2 cells are treated with or without cryptogein in the presence or absence of DFMO(Difluoromethylornithine) and monitered the effect of chemicals on cell growth.
Animal Study:

[3]
  • Animal Models

    Rats

  • Dosages

    400 mg/kg

  • Administration

    s.c.

Selleck's Eflornithine (DFMO) hydrochloride hydrate has been cited by 8 publications

WR1065 conjugated to thiol-PEG polymers as novel anticancer prodrugs: broad spectrum efficacy, synergism, and drug resistance reversal [ Front Oncol, 2023, 13:1212604] PubMed: 37576902
Postinfection Metabolic Reprogramming of the Murine Trigeminal Ganglion Limits Herpes Simplex Virus-1 Replication [ mBio, 2022, 13(5):e0219422] PubMed: 36043789
The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia [ iScience, 2022, 25(3):103881] PubMed: 35243242
Arginine Regulates Zygotic Genome Activation in Porcine Embryos Under Nutrition Restriction [ Front Vet Sci, 2022, 9:921406] PubMed: 35812864
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity [ Cell, 2021, S0092-8674(21)00700-5] PubMed: 34216539
Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer [ Int J Mol Sci, 2021, 22(19)10255] PubMed: 34638596
Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer [ Int J Mol Sci, 2021, 22(19), 10255] PubMed: None
Difluoromethylornithine, a Decarboxylase 1 Inhibitor, Suppresses Hepatitis B Virus Replication by Reducing HBc Protein Levels. [ Front Cell Infect Microbiol, 2020, 16;10:158] PubMed: 32373551

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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