Epalrestat

Catalog No.S2035 Batch:S203501

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Technical Data

Formula

C15H13NO3S2
Molecular Weight 319.4 CAS No. 82159-09-9
Solubility (25°C)* In vitro DMSO 2 mg/mL (6.26 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM.
In vitro

Epalrestat (ONO-2235) is an aldose reductase inhibitor.

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    Primary hepatocytes

  • Concentrations

    50 mM

  • Incubation Time

    24 h

  • Method

    Cells were treated with indicated concentrations of drug for 24 h.
Animal Study:

[2]
  • Animal Models

    Xenograft mice

  • Dosages

    100 mg/kg

  • Administration

    o.g.

Selleck's Epalrestat has been cited by 5 publications

Tracer metabolomics reveals the role of aldose reductase in glycosylation [ Cell Rep Med, 2023, 4(6):101056] PubMed: 37257447
ER stress-induced adipocytes secrete-aldo-keto reductase 1B7-containing exosomes that cause nonalcoholic steatohepatitis in mice [ Free Radic Biol Med, 2021, 163:220-233] PubMed: 33359683
Aldose Reductase Inhibitor Engeletin Suppresses Pelvic Inflammatory Disease by Blocking the Phospholipase C/Protein Kinase C-Dependent/NF-κB and MAPK Cascades [ J Agric Food Chem, 2020, 68(42):11747-11757] PubMed: 33047600
AKR1B10 Inhibitor Epalrestat Facilitates Sorafenib-Induced Apoptosis and Autophagy Via Targeting the mTOR Pathway in Hepatocellular Carcinoma [ Int J Med Sci, 2020, 17(9):1246-1256] PubMed: 32547320
The AKR1B1 inhibitor epalrestat suppresses the progression of cervical cancer [ Mol Biol Rep, 2020, 10.1007/s11033-020-05685-z] PubMed: 32761301

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.