|
Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. |
Technical Data
| Formula | C22H24ClFN4O3.HCl |
|||
| Molecular Weight | 483.36 | CAS No. | 184475-55-6 | |
| Solubility (25°C)* | In vitro | DMSO | 4 mg/mL (8.27 mM) | |
| Water | 1 mg/mL (2.06 mM) | |||
| Ethanol | 1 mg/mL (2.06 mM) | |||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
||||
Preparing Stock Solutions
Biological Activity
| Description | Gefitinib (ZD1839) is an EGFR inhibitor with IC50s of 15.5 nM and 823.3 nM for WT EGFR and EGFR (858R/T790M), respectively. | ||||
|---|---|---|---|---|---|
| Targets |
|
Protocol (from reference)
Selleck's Gefitinib hydrochloride has been cited by 241 publications
| Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition [ Cancer Res, 2023, 83(2):316-331] | PubMed: 36409827 |
| Irreversible tyrosine kinase inhibitors induce the endocytosis and downregulation of ErbB2 [ Biochem Biophys Rep, 2023, 34:101436] | PubMed: 36824069 |
| Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma [ Mol Cancer, 2022, 21(1):43] | PubMed: 35144642 |
| Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select [ Nat Genet, 2022, 54(12):1983-1993] | PubMed: 36471068 |
| Colorectal Cancer Patient-Derived 2D and 3D Models Efficiently Recapitulate Inter- and Intratumoral Heterogeneity [ Adv Sci (Weinh), 2022, e2201539] | PubMed: 35652270 |
| The reversible fourth-generation EGFR tyrosine kinase inhibitor OBX02-011 overcomes C797S-mediated resistance in lung cancer [ Cancer Res, 2022, canres.0394.2022-2-3 21:03:12.200] | PubMed: 35700239 |
| Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR [ Cell Death Dis, 2022, 13(1):41] | PubMed: 35013118 |
| Multi-omics analysis reveals the mechanisms of action and therapeutic regimens of traditional Chinese medicine, Bufei Jianpi granules: Implication for COPD drug discovery [ Phytomedicine, 2022, 98:153963] | PubMed: 35121390 |
| Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies [ Antiviral Res, 2022, 204:105367] | PubMed: 35738348 |
| Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer [ J Med Chem, 2022, 65(14):9662-9677] | PubMed: 35838760 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.