H-151

Catalog No.S6652 Batch:S665202

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Technical Data

Formula

C17H17N3O
Molecular Weight 279.34 CAS No. 941987-60-6
Solubility (25°C)* In vitro DMSO 56 mg/mL (200.47 mM)
Ethanol 8 mg/mL (28.63 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
5.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description H-151 is a highly potent and covalent antagonist of STING that has noteworthy inhibitory activity both in human cells and in vivo.
Targets
STING [1]
In vivo

After intraperitoneal administration, H-151 reachs effective systemic levels, displays a short half-life in the serum and formed an adduct to mmSTING. Notably, pretreatment of H-151 markedly reduces systemic cytokine responses in CMA-treated mice. Moreover, H-151 exhibits notable efficacy in Trex1−/− mice that expressed a bioluminescent IFNβ reporter, when administered for one week.[1]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    FLDMs

  • Concentrations

    25 µM

  • Incubation Time

    12 h

  • Method

    Cells were treated with indicated concentrations of drug.
Animal Study:

[2]
  • Animal Models

    C57BL/6J mice

  • Dosages

    750 nM

  • Administration

    i.p.

Selleck's H-151 has been cited by 17 publications

Inhibiting autophagy enhanced mitotic catastrophe-mediated anticancer immune responses by regulating the cGAS-STING pathway [ Cancer Lett, 2024, 586:216695] PubMed: 38325769
Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity [ Int J Biol Sci, 2023, 19(3):981-993] PubMed: 36778120
mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING [ Mol Immunol, 2023, 154:45-53] PubMed: 36603304
BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma [ Cancer Lett, 2022, 547:215885] PubMed: 35995140
Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation [ Cell Rep, 2022, 41-1:111434] PubMed: 36198273
WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC [ Cell Rep, 2022, 39(7):110814] PubMed: 35584676
Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase [ Free Radic Biol Med, 2022, 193(Pt 1):202-212] PubMed: 36228830
SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways [ Mol Med, 2022, 28(1):125] PubMed: 36273174
AKT1 Is Required for a Complete Palbociclib-Induced Senescence Phenotype in BRAF-V600E-Driven Human Melanoma [ Cancers (Basel), 2022, 14(3)572] PubMed: 35158840
Pharmacological activation of STING blocks SARS-CoV-2 infection [ Sci Immunol, 2021, 6(59)eabi9007] PubMed: 34010142

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.