Nitrofurantoin

Catalog No.S4536 Batch:S453601

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Technical Data

Formula

C8H6N4O5
Molecular Weight 238.16 CAS No. 67-20-9
Solubility (25°C)* In vitro DMSO 47 mg/mL (197.34 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis.
In vitro Nitrofurantoin is very effective against both outdoor and indoor urinary isolates and can be used empirically for uncomplicated urinary tract infections[3]. Nitrofurantoin can directly injure lung parenchymal cells, probably through oxidant mechanisms[2].

Protocol (from reference)

Cell Assay:[1]
  • Cell lines

    HeLa cell

  • Concentrations

    5, 10, 20, 40 μM

  • Incubation Time

    24 h

  • Method

    HeLa cells are grown and infected with T. gondii for 24 hr in a 96-well microplate, and then treated with drugs. After 24 hr, 20 μl of MTS solution is added directly into culture wells, followed by incubating for 1.5 hr at 37˚C and measuring the absorbance at 490 nm in a microplate reader.

Selleck's Nitrofurantoin has been cited by 1 publication

Nitrofuran Derivatives Cross-Resistance Evidence-Uropathogenic Escherichia coli Nitrofurantoin and Furazidin In Vitro Susceptibility Testing [ J Clin Med, 2023, 12(16)5166] PubMed: 37629208

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.