Penfluridol

Catalog No.S4151 Batch:S415102

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Technical Data

Formula

C28H27ClF5NO
Molecular Weight 523.97 CAS No. 26864-56-2
Solubility (25°C)* In vitro DMSO 100 mg/mL (190.85 mM)
Ethanol 100 mg/mL (190.85 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
5.0mg/ml
5% DMSO 95% Corn oil
5.0mg/ml
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Penfluridol (TLP-607,R-16341) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
Targets
Dopamine receptor [1]
(Cell-free assay)
1.6 μM(Ki)
In vitro

Penfluridol is a neuroleptic drug with long duration of action, which is able to relieve both negative and positive symptoms of schizophrenia. Penfluridol inhibits the binding of dopamine to dopamine receptor with Ki of 1.6 μM. It exerts its antipsychotic activity by blocking the dopamine projections in the limbic system and in mesocortical area. [1] Penfluridol selectively inhibits the binding of [3H]nitrendipine to rat cerebral cortical membrane fraction and also competitively antagonizes potassium-induced calcium-dependent contractions in rat vas deferens. Penfluridol (10 μM) inhibits the contractile response of isolated rings of rabbit thoracic aorta to NE and KCl, and inhibits calcium influx during either NE or KCl stimulation. [2]

Protocol (from reference)

Selleck's Penfluridol has been cited by 3 publications

Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner [ Acta Pharm Sin B, 2022, 12(3):1271-1287] PubMed: 35530161
The Food and Drug Administration-approved antipsychotic drug trifluoperazine, a calmodulin antagonist, inhibits viral replication through PERK-eIF2α axis [ Front Microbiol, 2022, 13:979904] PubMed: 36386620
Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner [ Acta Pharmaceutica Sinica B, 2021, 10.1016/j.apsb.2021.09.007] PubMed: None

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.