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Technical Data
| Formula | C20H19FN8O2 |
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| Molecular Weight | 422.42 | CAS No. | 625115-55-1 | |
| Solubility (25°C)* | In vitro | DMSO | 84 mg/mL (198.85 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Riociguat is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension. | |
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| Targets |
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| In vitro | BAY 63-2521 stimulates the recombinant sGC concentration dependently from 0.1 to 100 μM with a two-fold to 73-fold effect by an NO-independent but haem-dependent mechanism. [1] Riociguat inhibits platelet function in washed platelets but not in whole blood, and exerts no direct effects on contractility and relaxation of cardiac myocytes. [2] [3] | |
| In vivo | In chronic treatment of hypoxic mice and MCT-injected rats, Riociguat (10 mg/kg/d, p.o.) partially reverses the pulmonary arterial hypertension, the right heart hypertrophy and the structural remodelling of the lung vasculature. [1] |
Protocol (from reference)
| Animal Study:[1] |
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References
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Selleck's Riociguat has been cited by 9 publications
| Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury [ J Exp Med, 2023, 220(2)e20211422] | PubMed: 36350314 |
| Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes [ Open Biol, 2022, 12(8):220058] | PubMed: 35975649 |
| Single-cell transcriptomic analysis reveals a hepatic stellate cell-activation roadmap and myofibroblast origin during liver fibrosis [ Hepatology, 2021, 10.1002/hep.31987] | PubMed: 34089528 |
| Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury [ Int J Mol Sci, 2021, 22(22)12485] | PubMed: 34830371 |
| Soluble guanylate cyclase stimulator reduced the gastrointestinal fibrosis in bleomycin-induced mouse model of systemic sclerosis [ Arthritis Res Ther, 2021, 23(1):133] | PubMed: 33941248 |
| Novel Targets in a High-Altitude Pulmonary Hypertension Rat Model Based on RNA-seq and Proteomics [ Front Med (Lausanne), 2021, 8:742436] | PubMed: 34805208 |
| Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling. [ Cell Rep, 2019, 27(6):1769-1780] | PubMed: 31067462 |
| TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells. [ Oncogene, 2019, 38(22):4397-4411] | PubMed: 30718921 |
| Non-canonical AR activity facilitates endocrine resistance in breast cancer. [ Endocr Relat Cancer, 2019, 26(2):251-264] | PubMed: 30557851 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.