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Technical Data
| Formula | C10H12N2O.HCl |
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| Molecular Weight | 212.68 | CAS No. | 153-98-0 | |
| Solubility (25°C)* | In vitro | DMSO | 43 mg/mL (202.18 mM) | |
| Water | 42 mg/mL (197.47 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Serotonin (5-HT) HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist. | |
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| In vitro | Serotonin stimulates acid–base transport by the anterior stomach region of the midgut in vitro. The function of this stimulation is assumed to be maintenance of optimal conditions for digestion and absorption of nutrients rather than regulation of hemolymph acid–base homeostasis. [1] | |
| In vivo | The role of serotonin in the regulation of larval Aedes aegypti hemolymph composition is investigated in vivo using two reuptake inhibitors (SSRIs), alaproclate HCl and 6-nitroquipazine maleate, and the receptor antagonist methiothepin mesylate. [1] |
Protocol (from reference)
Selleck's Serotonin (5-HT) HCl has been cited by 7 publications
| Immunophenotypic and molecular characterization of pancreatic neuroendocrine tumors producing serotonin [ Mod Pathol, 2022, 10.1038/s41379-022-01110-x] | PubMed: 35739266 |
| Regular Aerobic Exercise Attenuates Pain and Anxiety in Mice by Restoring Serotonin-Modulated Synaptic Plasticity in the Anterior Cingulate Cortex [ Med Sci Sports Exerc, 2022, 54(4):566-581] | PubMed: 34935710 |
| Increasing serotonin concentrations alter calcium metabolism in periparturient dairy goats [ J Anim Sci, 2022, skac065] | PubMed: 35235945 |
| Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer [ Theranostics, 2021, 11(14):6950-6965] | PubMed: 34093864 |
| Role of 5-HT degradation in acute liver injury induced by carbon tetrachloride [ Eur J Pharmacol, 2021, 908:174355] | PubMed: 34280394 |
| Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines [ Sci Rep, 2021, 11(1):1250] | PubMed: 33441923 |
| Relationship between fatigue caused by type 2 diabetes mellitus and 5-HT degradation in skeletal muscle [ Acta Pharmaceutica Sinica, 2021, 56(1): 190-200] | PubMed: None |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.