Trihexyphenidyl hydrochloride

Catalog No.S4542 Batch:S454201

Technical Data

Formula	C₂₀H₃₁NO.HCl
Molecular Weight	337.93	CAS No.	52-49-3
Solubility (25°C)*	In vitro	Ethanol	24 mg/mL (71.02 mM)
		DMSO	7 mg/mL (20.71 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Trihexyphenidyl hydrochloride (Benzhexol, Artane) is an antiparkinsonian agent of the antimuscarinic class.
In vivo	Trihexyphenidyl-treated rats exhibits significantly extended mean latencies during the initial 3 months of testing; however, this behavioral deficit is restored between the fourth and sixth month of MWM testing. The most significant populations of genes downregulated by THP are the immune response-, antigen processing and presentation-, and major histocompatibility complex (MHC)-related genes, as validated by qRT-PCR. In aging brains, THP treatment decreases expression of MHC class I. Its long-term treatment primes hippocampal and cortical microglia to undergo an inflammatory phenotypic switch, causing microgliosis and microglia activation, which are positively accompanied by pathological misfolded tau lesions^[1].TPH induces dose-dependent structural changes in rat frontal cortex motor area^[2].

Description

Trihexyphenidyl hydrochloride (Benzhexol, Artane) is an antiparkinsonian agent of the antimuscarinic class.

In vivo

Trihexyphenidyl-treated rats exhibits significantly extended mean latencies during the initial 3 months of testing; however, this behavioral deficit is restored between the fourth and sixth month of MWM testing. The most significant populations of genes downregulated by THP are the immune response-, antigen processing and presentation-, and major histocompatibility complex (MHC)-related genes, as validated by qRT-PCR. In aging brains, THP treatment decreases expression of MHC class I. Its long-term treatment primes hippocampal and cortical microglia to undergo an inflammatory phenotypic switch, causing microgliosis and microglia activation, which are positively accompanied by pathological misfolded tau lesions^[1].TPH induces dose-dependent structural changes in rat frontal cortex motor area^[2].

Protocol (from reference)

Animal Study:^{^[1]}	Animal Models Male Sprague-Dawley rats (SD) Dosages 0.3 and 1.0 mg/kg Administration i.p.

References

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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