Home Metabolism P450 (e.g. CYP17) inhibitor - Histone Acetyltransferase inhibitor - Transferase inhibitor 1-Aminobenzotriazole For research use only.

1-Aminobenzotriazole

Synonyms: ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987

1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).

1-Aminobenzotriazole Chemical Structure

1-Aminobenzotriazole Chemical Structure

CAS: 1614-12-6

Purity & Quality Control

Batch: S688601 DMSO] 27 mg/mL] false] Water] 27 mg/mL] false] Ethanol] 27 mg/mL] false Purity: 99.99%
99.99

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Biological Activity

Description 1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).
Targets
P450 [1] NAT [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05532696 Recruiting Advanced Solid Tumor|Non Small Cell Lung Cancer|HER2 Mutations Anbogen Therapeutics Inc. September 27 2022 Phase 1|Phase 2
NCT05449249 Completed Healthy|Periodontitis Buchinger Wilhelmi Development & Holding GmbH|Buchinger Wilhelmi Clinic|University of Geneva Switzerland|King''s College London|ETH Zurich (Switzerland) September 1 2022 Not Applicable
NCT06108869 Suspended Chronic Spontaneous Urticaria Royal College of Surgeons Ireland June 1 2022 Not Applicable
NCT04053569 Active not recruiting Metabolic Syndrome Protection Against Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis October 1 2019 Not Applicable
NCT04006353 Completed Drug Interaction Shanghai Public Health Clinical Center July 11 2019 Phase 4
NCT03935022 Completed Healthy University of Milan March 6 2019 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 134.14 Formula
C6H6N4
CAS No. 1614-12-6 SDF --
Smiles N[N]1N=NC2=CC=CC=C12
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 27 mg/mL ( (201.28 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 27 mg/mL

Ethanol : 27 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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