Home Endocrinology & Hormones DNA Methyltransferase inhibitor 2'-Deoxy-5-Fluorocytidine For research use only.

2'-Deoxy-5-Fluorocytidine

Synonyms: 5-fluoro-2(')-deoxycytidine, FCdR

2'-Deoxy-5-fluorocytidine (5-fluoro-2(')-deoxycytidine, FCdR), a pyrimidine analog, is a DNA methyltransferase (DMNT) inhibitor currently in clinical trials for solid tumors.

2'-Deoxy-5-Fluorocytidine Chemical Structure

2'-Deoxy-5-Fluorocytidine Chemical Structure

CAS: 10356-76-0

Purity & Quality Control

Batch: S247701 DMSO] 49 mg/mL] false] Water] 12 mg/mL] false] Ethanol] Insoluble] false Purity: 99.98%
99.98

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Biological Activity

Description 2'-Deoxy-5-fluorocytidine (5-fluoro-2(')-deoxycytidine, FCdR), a pyrimidine analog, is a DNA methyltransferase (DMNT) inhibitor currently in clinical trials for solid tumors.
Targets
DNA methylation [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01199250 Not yet recruiting Lynch Syndrome|Recurrent Uterine Corpus Carcinoma|Stage I Uterine Corpus Cancer|Stage II Uterine Corpus Cancer|Stage III Uterine Corpus Cancer|Stage IV Uterine Corpus Cancer Gynecologic Oncology Group|National Cancer Institute (NCI)|GOG Foundation January 2100 --
NCT04598516 Withdrawn Acute Kidney Injury (Nontraumatic)|Contrast-induced Nephropathy|Renal Insufficiency Maastricht University Medical Center November 1 2097 --
NCT04662164 Withdrawn Type 2 Diabetes Patients Shanghai HEP Pharmaceutical Co. Ltd. December 2025 Phase 1|Phase 2
NCT01037387 Recruiting Chronic Obstructive Pulmonary Disease|Hypercapnic Hospital Universitario La Paz December 2025 Phase 4

Chemical lnformation & Solubility

Molecular Weight 245.21 Formula

C9H12FN3O4
CAS No. 10356-76-0 SDF --
Smiles C1C(C(OC1N2C=C(C(=NC2=O)N)F)CO)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 49 mg/mL ( (199.82 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 12 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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