Home Endocrinology & Hormones Androgen Receptor antagonist 3,3'-Diindolylmethane For research use only.

3,3'-Diindolylmethane

Synonyms: DIM

3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. 3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.

3,3'-Diindolylmethane Chemical Structure

3,3'-Diindolylmethane Chemical Structure

CAS: 1968-05-4

Selleck's 3,3'-Diindolylmethane has been cited by 2 publications

Purity & Quality Control

Batch: S472801 DMSO] 49 mg/mL] false] Ethanol] 18 mg/mL] false] Water] Insoluble] false Purity: 98.07%
98.07

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Biological Activity

Description 3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. 3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.
Targets
Androgen Receptor [1]
In vitro
In vitro DIM is a potent radioprotector and mitigator that functions by stimulating an ATM-driven DDR-like response and NF-κB survival signaling. DIM can inhibit invasion, angiogenesis, and proliferation and induce apoptosis in tumor cells by modulating signaling pathways involving AKT, NF-κB, and FOXO3. It can also inhibit estrogen-inducible gene expression and cause an endoplasmic reticulum stress response. DIM alters estrogen metabolism by shifting metabolism from carcinogenic 16α-hydroxy to inert 2-hydroxy derivatives, and it antagonizes estrogen and androgen receptor activity[1].
Cell Research Cell lines 184A1 and Hs578Bst cells
Concentrations 0.3 μM
Incubation Time 24 h
Method The 184A1 and Hs578Bst cells are pretreated with DIM (0.3 μM) or vehicle for 24 h, irradiated by using different doses of 137Cs γ rays, harvested, plated at different densities, incubated for 14 d, and counted for colony formation.
In Vivo
In vivo Preliminary studies show DIM is most effective against total body irradiation (TBI) when given in multiple once-daily doses. Treatment of DIM has radioprotection and mitigation properties in vivo. DIM Activates ATM in Normal Tissues. DIM can be given to mice (250 mg/kg) by oral gavage, with no acute toxicity and excellent bioavailability[1].
Animal Research Animal Models Sprague-Dawley (SD) rats
Dosages 75 mg/kg
Administration i.p

Chemical lnformation & Solubility

Molecular Weight 246.31 Formula

C17H14N2
CAS No. 1968-05-4 SDF Download 3,3'-Diindolylmethane SDF
Smiles C1=CC=C2C(=C1)C(=CN2)CC3=CNC4=CC=CC=C43
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 49 mg/mL ( (198.93 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 18 mg/mL

Water : Insoluble


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In vivo
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