Home Microbiology Reverse Transcriptase inhibitor - DNA/RNA Synthesis inhibitor - HIV inhibitor 3'-Fluoro-3'-deoxythymidine (Alovudine) For research use only.

3'-Fluoro-3'-deoxythymidine (Alovudine)

Synonyms: CL 184824, FddThd, FLT, MIV-310

3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.

3'-Fluoro-3'-deoxythymidine (Alovudine) Chemical Structure

3'-Fluoro-3'-deoxythymidine (Alovudine) Chemical Structure

CAS: 25526-93-6

Purity & Quality Control

Batch: S684801 DMSO] 49 mg/mL] false] Ethanol] 40 mg/mL] false] Water] 20 mg/mL] false Purity: 99.9%
99.9

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Biological Activity

Description 3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
Targets
polymerase γ [3] Reverse transcriptase [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05947344 Recruiting AML Adult Zhejiang ACEA Pharmaceutical Co. Ltd. December 8 2023 Phase 1
NCT05232994 Not yet recruiting Preeclampsia Severe|Preeclampsia Second Trimester|Preterm Birth Complication Christiana Care Health Services March 1 2023 Phase 1
NCT05697510 Recruiting Acute Myeloid Leukemia (AML) Nantes University Hospital March 16 2023 Phase 1
NCT03633955 Recruiting Acute Lymphocytic Leukemia|Acute Myeloid Leukemia|Ambiguous Lineage Leukemia or Lymphoma|Myeloma University of Oklahoma|Emory University January 19 2023 Phase 1

Chemical lnformation & Solubility

Molecular Weight 244.22 Formula

C10H13FN2O4
CAS No. 25526-93-6 SDF --
Smiles CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)F
Storage (From the date of receipt) 3 years -20°C(in the dark) powder

In vitro
Batch:

DMSO : 49 mg/mL ( (200.63 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 40 mg/mL

Water : 20 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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