Home Immunology & Inflammation COX inhibitor 4-Aminoantipyrine For research use only.

4-Aminoantipyrine

Synonyms: Ampyrone, NSC 60242, Metapirazone, Solnapyrin-A, Solvapyrin-A, Minoazophene, Aminoazophene, Aminoantipyrin

4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.

4-Aminoantipyrine Chemical Structure

4-Aminoantipyrine Chemical Structure

CAS: 83-07-8

Purity & Quality Control

Batch: S450901 DMSO] 40 mg/mL] false] Water] 40 mg/mL] false] Ethanol] 40 mg/mL] false Purity: 99.23%
99.23

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Biological Activity

Description 4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
In vitro
In vitro The level of glutathione(GSH) in single erythrocytes is impacted slightly at low AAP(4-aminoantipyrine) concentrations probably due to the protection of glutathione reductase. When AAP concentration further increases, AAP has a significant influence on GSH[2].
Cell Research Cell lines Human erythrocytes
Concentrations 1 × 10−6 mol/L to 1 × 10−3 mol/L
Incubation Time 2 h
Method

Erythrocytes in PBS are incubated for 2 h at ambient temperature (without mixing) with AAP in concentrations from 1 × 10−6 mol/L to 1 × 10−3 mol/L. Sample of erythrocytes without AAP is used as control. After the exposure of AAP, erythrocytes are washed with borate buffer (pH 9.0) 2 times by centrifuging and determined for GSH.
In Vivo
In vivo 4-aminoantipyrine (4-AA) is not genotoxic and mutagenic in vivo, it can interfere with DNA damaging agents biological activities and may reduce the effectiveness of DNA damage-based chemotherapy[3].
Animal Research Animal Models Male Wistar rats
Dosages 240 µmol/kg
Administration iv(caudal vein)

Chemical lnformation & Solubility

Molecular Weight 203.24 Formula

C11H13N3O
CAS No. 83-07-8 SDF Download 4-Aminoantipyrine SDF
Smiles CC1=C(C(=O)N(N1C)C2=CC=CC=C2)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 40 mg/mL ( (196.81 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 40 mg/mL

Ethanol : 40 mg/mL


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In vivo
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