Home Others PROTAC Linker chemical EdU (5-Ethynyl-2'-deoxyuridine) For research use only.

EdU (5-Ethynyl-2'-deoxyuridine)

Synonyms: 5-EdU, 2'-Deoxy-5-ethynyluridine

EdU (5-Ethynyl-2'-deoxyuridine), a thymidine analogue, which can be incorporated into cellular DNA and the subsequent reaction of EdU with a fluorescent azide in a copper-catalyzed [3+2] cycloaddition ("Click" reaction) are developed as a method for detection of DNA synthesis. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.

EdU (5-Ethynyl-2'-deoxyuridine) Chemical Structure

EdU (5-Ethynyl-2'-deoxyuridine) Chemical Structure

CAS: 61135-33-9

Selleck's EdU (5-Ethynyl-2'-deoxyuridine) has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.82%
99.82

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Biological Activity

Description EdU (5-Ethynyl-2'-deoxyuridine), a thymidine analogue, which can be incorporated into cellular DNA and the subsequent reaction of EdU with a fluorescent azide in a copper-catalyzed [3+2] cycloaddition ("Click" reaction) are developed as a method for detection of DNA synthesis. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
In Vivo
In vivo

5-Ethynyl-2'-deoxyuridine (EdU, 5-EdU, 2'-Deoxy-5-ethynyluridine), a thymidine analogue developed for detection of DNA synthesis, the number of EdU positive cells in the dentate gyrus of the hippocampus (DG) were slightly increased in a dose dependent manner in voluntary exercise (running) mouse groups, while decreased in restraint stress mouse model significantly.[2]
Animal Research Animal Models Voluntary exercise mouse model, Restraint stress mouse model
Dosages 10, 20, 50, 100 or 200 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05923944 Not yet recruiting Anxiety|Anxiety Disorders and Symptoms School of Health Sciences Geneva|University of Geneva Switzerland|University of Haifa|Swiss National Science Foundation January 2024 Not Applicable
NCT05599191 Recruiting Refractory Chronic Cough Bellus Health Inc. - a GSK company October 25 2022 Phase 3
NCT05459974 Recruiting Atrial Fibrillation Stony Brook University June 20 2022 Phase 3
NCT05160935 Completed Coronary Angiography|Anxiety|Vital Signs|Education|Nursing|Nursing Care Eskisehir Osmangazi University January 1 2022 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 252.22 Formula

C11H12N2O5
CAS No. 61135-33-9 SDF --
Smiles C#CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 50 mg/mL ( (198.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 10 mg/mL

Ethanol : Insoluble


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In vivo
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