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AZD7762
AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
AZD7762 Chemical Structure
CAS: 860352-01-8
Selleck's AZD7762 has been cited by 122 publications
Purity & Quality Control
Batch:
Purity:
99.98%
99.98
Other Chk Products
Related compound libraries
Choose Selective Chk Inhibitors
Cell Data
| Cell Lines | Assay Type | Concentration | Incubation Time | Formulation | Activity Description | PMID |
|---|---|---|---|---|---|---|
| KASUMI-1 | Growth Inhibition Assay | IC50=0.000234 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=0.000415 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=0.000425 μM | SANGER | |||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.00643 μM | SANGER | |||
| A204 | Growth Inhibition Assay | IC50=0.00856 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.0142 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=0.02849 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=0.0312 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=0.03142 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=0.03251 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=0.03417 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=0.03442 μM | SANGER | |||
| SW756 | Growth Inhibition Assay | IC50=0.03579 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=0.03896 μM | SANGER | |||
| HCC1806 | Growth Inhibition Assay | IC50=0.04022 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=0.04203 μM | SANGER | |||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=0.04316 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=0.04592 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=0.05158 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.06025 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.06102 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=0.06115 μM | SANGER | |||
| NB14 | Growth Inhibition Assay | IC50=0.06136 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=0.06196 μM | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.06255 μM | SANGER | |||
| G-402 | Growth Inhibition Assay | IC50=0.0646 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=0.07146 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=0.0739 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=0.07486 μM | SANGER | |||
| OC-314 | Growth Inhibition Assay | IC50=0.07807 μM | SANGER | |||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.08421 μM | SANGER | |||
| MDA-MB-157 | Growth Inhibition Assay | IC50=0.08659 μM | SANGER | |||
| HuP-T3 | Growth Inhibition Assay | IC50=0.0871 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=0.08806 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=0.08807 μM | SANGER | |||
| COLO-679 | Growth Inhibition Assay | IC50=0.09091 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=0.09903 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=0.09918 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.10033 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=0.102 μM | SANGER | |||
| HSC-4 | Growth Inhibition Assay | IC50=0.10554 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=0.11063 μM | SANGER | |||
| TGBC11TKB | Growth Inhibition Assay | IC50=0.11093 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.1186 μM | SANGER | |||
| H9 | Growth Inhibition Assay | IC50=0.12165 μM | SANGER | |||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.1225 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=0.12484 μM | SANGER | |||
| MC-IXC | Growth Inhibition Assay | IC50=0.12843 μM | SANGER | |||
| KYSE-140 | Growth Inhibition Assay | IC50=0.13041 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=0.13064 μM | SANGER | |||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.13128 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=0.1316 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=0.13325 μM | SANGER | |||
| ACHN | Growth Inhibition Assay | IC50=0.13369 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=0.13476 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=0.1368 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=0.13687 μM | SANGER | |||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.13894 μM | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | IC50=0.13925 μM | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.14288 μM | SANGER | |||
| M14 | Growth Inhibition Assay | IC50=0.14463 μM | SANGER | |||
| D-566MG | Growth Inhibition Assay | IC50=0.1469 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=0.14842 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=0.14967 μM | SANGER | |||
| YH-13 | Growth Inhibition Assay | IC50=0.15674 μM | SANGER | |||
| NB17 | Growth Inhibition Assay | IC50=0.15786 μM | SANGER | |||
| U-2-OS | Growth Inhibition Assay | IC50=0.15847 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=0.16011 μM | SANGER | |||
| LoVo | Growth Inhibition Assay | IC50=0.16166 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.16311 μM | SANGER | |||
| ESS-1 | Growth Inhibition Assay | IC50=0.16413 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=0.16503 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=0.16535 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=0.1683 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.16847 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=0.17171 μM | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.17464 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=0.17827 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.18599 μM | SANGER | |||
| SK-N-AS | Growth Inhibition Assay | IC50=0.18815 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=0.18905 μM | SANGER | |||
| 5637 | Growth Inhibition Assay | IC50=0.19278 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=0.19561 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=0.19761 μM | SANGER | |||
| CHP-212 | Growth Inhibition Assay | IC50=0.19782 μM | SANGER | |||
| A427 | Growth Inhibition Assay | IC50=0.19832 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=0.20117 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=0.20318 μM | SANGER | |||
| TI-73 | Growth Inhibition Assay | IC50=0.20873 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=0.2097 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=0.21429 μM | SANGER | |||
| H4 | Growth Inhibition Assay | IC50=0.22062 μM | SANGER | |||
| EPLC-272H | Growth Inhibition Assay | IC50=0.22068 μM | SANGER | |||
| COR-L105 | Growth Inhibition Assay | IC50=0.22235 μM | SANGER | |||
| 769-P | Growth Inhibition Assay | IC50=0.22298 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=0.22454 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.22557 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.2257 μM | SANGER | |||
| KYSE-270 | Growth Inhibition Assay | IC50=0.22633 μM | SANGER | |||
| RH-1 | Growth Inhibition Assay | IC50=0.22666 μM | SANGER | |||
| JVM-3 | Growth Inhibition Assay | IC50=0.23036 μM | SANGER | |||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.23056 μM | SANGER | |||
| JAR | Growth Inhibition Assay | IC50=0.23238 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=0.2385 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=0.24243 μM | SANGER | |||
| SNU-387 | Growth Inhibition Assay | IC50=0.24339 μM | SANGER | |||
| IGROV-1 | Growth Inhibition Assay | IC50=0.24401 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=0.24451 μM | SANGER | |||
| T98G | Growth Inhibition Assay | IC50=0.24568 μM | SANGER | |||
| NCI-H510A | Growth Inhibition Assay | IC50=0.24626 μM | SANGER | |||
| KOSC-2 | Growth Inhibition Assay | IC50=0.24671 μM | SANGER | |||
| NCI-H23 | Growth Inhibition Assay | IC50=0.24761 μM | SANGER | |||
| MC116 | Growth Inhibition Assay | IC50=0.25654 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.25768 μM | SANGER | |||
| ABC-1 | Growth Inhibition Assay | IC50=0.26064 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.26678 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.27059 μM | SANGER | |||
| HCC1395 | Growth Inhibition Assay | IC50=0.27089 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=0.27097 μM | SANGER | |||
| NCI-H1755 | Growth Inhibition Assay | IC50=0.27304 μM | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.27385 μM | SANGER | |||
| MKN45 | Growth Inhibition Assay | IC50=0.2798 μM | SANGER | |||
| TYK-nu | Growth Inhibition Assay | IC50=0.2806 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=0.28134 μM | SANGER | |||
| H-EMC-SS | Growth Inhibition Assay | IC50=0.28354 μM | SANGER | |||
| CAKI-1 | Growth Inhibition Assay | IC50=0.2868 μM | SANGER | |||
| EW-24 | Growth Inhibition Assay | IC50=0.2891 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=0.29008 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.29154 μM | SANGER | |||
| HOP-92 | Growth Inhibition Assay | IC50=0.29279 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=0.29406 μM | SANGER | |||
| NCI-H28 | Growth Inhibition Assay | IC50=0.29704 μM | SANGER | |||
| HuO9 | Growth Inhibition Assay | IC50=0.29793 μM | SANGER | |||
| SF295 | Growth Inhibition Assay | IC50=0.29802 μM | SANGER | |||
| COLO-829 | Growth Inhibition Assay | IC50=0.29845 μM | SANGER | |||
| MSTO-211H | Growth Inhibition Assay | IC50=0.29855 μM | SANGER | |||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.29896 μM | SANGER | |||
| FTC-133 | Growth Inhibition Assay | IC50=0.30265 μM | SANGER | |||
| Mewo | Growth Inhibition Assay | IC50=0.30431 μM | SANGER | |||
| HCC70 | Growth Inhibition Assay | IC50=0.30665 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=0.31525 μM | SANGER | |||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.31566 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=0.3165 μM | SANGER | |||
| NBsusSR | Growth Inhibition Assay | IC50=0.31819 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.32021 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=0.32353 μM | SANGER | |||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.32489 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=0.32594 μM | SANGER | |||
| D-423MG | Growth Inhibition Assay | IC50=0.33142 μM | SANGER | |||
| Detroit562 | Growth Inhibition Assay | IC50=0.33343 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=0.3381 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=0.34584 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=0.34596 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=0.34677 μM | SANGER | |||
| C32 | Growth Inhibition Assay | IC50=0.34682 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=0.34875 μM | SANGER | |||
| KP-N-YN | Growth Inhibition Assay | IC50=0.34887 μM | SANGER | |||
| MKN1 | Growth Inhibition Assay | IC50=0.35002 μM | SANGER | |||
| 8505C | Growth Inhibition Assay | IC50=0.35002 μM | SANGER | |||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.35584 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=0.35696 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=0.36482 μM | SANGER | |||
| T-24 | Growth Inhibition Assay | IC50=0.36985 μM | SANGER | |||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.37497 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=0.37606 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=0.37948 μM | SANGER | |||
| SW1990 | Growth Inhibition Assay | IC50=0.38353 μM | SANGER | |||
| GAMG | Growth Inhibition Assay | IC50=0.38567 μM | SANGER | |||
| G-361 | Growth Inhibition Assay | IC50=0.38712 μM | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | IC50=0.38792 μM | SANGER | |||
| 786-0 | Growth Inhibition Assay | IC50=0.38823 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=0.3897 μM | SANGER | |||
| OE33 | Growth Inhibition Assay | IC50=0.39118 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=0.40131 μM | SANGER | |||
| KYSE-180 | Growth Inhibition Assay | IC50=0.40151 μM | SANGER | |||
| NCI-H720 | Growth Inhibition Assay | IC50=0.40191 μM | SANGER | |||
| COR-L23 | Growth Inhibition Assay | IC50=0.40286 μM | SANGER | |||
| PFSK-1 | Growth Inhibition Assay | IC50=0.41092 μM | SANGER | |||
| FADU | Growth Inhibition Assay | IC50=0.41172 μM | SANGER | |||
| GP5d | Growth Inhibition Assay | IC50=0.41225 μM | SANGER | |||
| PC-14 | Growth Inhibition Assay | IC50=0.41661 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=0.41714 μM | SANGER | |||
| D-336MG | Growth Inhibition Assay | IC50=0.42138 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=0.42885 μM | SANGER | |||
| EFO-27 | Growth Inhibition Assay | IC50=0.43049 μM | SANGER | |||
| A2780 | Growth Inhibition Assay | IC50=0.43162 μM | SANGER | |||
| CAL-12T | Growth Inhibition Assay | IC50=0.43288 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=0.44185 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=0.44187 μM | SANGER | |||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.44293 μM | SANGER | |||
| Daoy | Growth Inhibition Assay | IC50=0.45103 μM | SANGER | |||
| A2058 | Growth Inhibition Assay | IC50=0.45136 μM | SANGER | |||
| Hs-578-T | Growth Inhibition Assay | IC50=0.45278 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=0.45293 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=0.4546 μM | SANGER | |||
| D-392MG | Growth Inhibition Assay | IC50=0.45612 μM | SANGER | |||
| MOLT-13 | Growth Inhibition Assay | IC50=0.46294 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=0.46419 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=0.46603 μM | SANGER | |||
| HuP-T4 | Growth Inhibition Assay | IC50=0.46868 μM | SANGER | |||
| NCI-H1563 | Growth Inhibition Assay | IC50=0.47035 μM | SANGER | |||
| U031 | Growth Inhibition Assay | IC50=0.48234 μM | SANGER | |||
| HSC-3 | Growth Inhibition Assay | IC50=0.48626 μM | SANGER | |||
| HT-3 | Growth Inhibition Assay | IC50=0.4903 μM | SANGER | |||
| HGC-27 | Growth Inhibition Assay | IC50=0.49115 μM | SANGER | |||
| HT-1080 | Growth Inhibition Assay | IC50=0.4927 μM | SANGER | |||
| RT-112 | Growth Inhibition Assay | IC50=0.49921 μM | SANGER | |||
| A375 | Growth Inhibition Assay | IC50=0.49922 μM | SANGER | |||
| SW626 | Growth Inhibition Assay | IC50=0.50633 μM | SANGER | |||
| SBC-5 | Growth Inhibition Assay | IC50=0.51344 μM | SANGER | |||
| CAL-51 | Growth Inhibition Assay | IC50=0.51437 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=0.52019 μM | SANGER | |||
| HC-1 | Growth Inhibition Assay | IC50=0.52114 μM | SANGER | |||
| CHL-1 | Growth Inhibition Assay | IC50=0.52551 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=0.53078 μM | SANGER | |||
| SNU-423 | Growth Inhibition Assay | IC50=0.53466 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=0.53657 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=0.53774 μM | SANGER | |||
| A704 | Growth Inhibition Assay | IC50=0.53881 μM | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | IC50=0.54077 μM | SANGER | |||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.5558 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=0.55933 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=0.56326 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=0.56522 μM | SANGER | |||
| KNS-62 | Growth Inhibition Assay | IC50=0.56553 μM | SANGER | |||
| CAL-62 | Growth Inhibition Assay | IC50=0.57121 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=0.57421 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=0.57497 μM | SANGER | |||
| AGS | Growth Inhibition Assay | IC50=0.58162 μM | SANGER | |||
| EW-22 | Growth Inhibition Assay | IC50=0.58375 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=0.58382 μM | SANGER | |||
| BFTC-909 | Growth Inhibition Assay | IC50=0.58833 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=0.59118 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=0.59129 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=0.60328 μM | SANGER | |||
| 647-V | Growth Inhibition Assay | IC50=0.61787 μM | SANGER | |||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.61861 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.6201 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=0.62788 μM | SANGER | |||
| NCI-H661 | Growth Inhibition Assay | IC50=0.63712 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=0.63721 μM | SANGER | |||
| SW1710 | Growth Inhibition Assay | IC50=0.64023 μM | SANGER | |||
| GCT | Growth Inhibition Assay | IC50=0.64935 μM | SANGER | |||
| SKG-IIIa | Growth Inhibition Assay | IC50=0.65036 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=0.6565 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=0.65805 μM | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | IC50=0.66068 μM | SANGER | |||
| SW620 | Growth Inhibition Assay | IC50=0.66223 μM | SANGER | |||
| AsPC-1 | Growth Inhibition Assay | IC50=0.66361 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=0.67625 μM | SANGER | |||
| RERF-LC-MS | Growth Inhibition Assay | IC50=0.67671 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.67852 μM | SANGER | |||
| 23132-87 | Growth Inhibition Assay | IC50=0.68306 μM | SANGER | |||
| BHY | Growth Inhibition Assay | IC50=0.68804 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=0.68928 μM | SANGER | |||
| A172 | Growth Inhibition Assay | IC50=0.69217 μM | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | IC50=0.69812 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=0.70549 μM | SANGER | |||
| HCC1937 | Growth Inhibition Assay | IC50=0.70631 μM | SANGER | |||
| HuCCT1 | Growth Inhibition Assay | IC50=0.70765 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=0.70781 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=0.72124 μM | SANGER | |||
| CFPAC-1 | Growth Inhibition Assay | IC50=0.72257 μM | SANGER | |||
| HOP-62 | Growth Inhibition Assay | IC50=0.7262 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=0.73552 μM | SANGER | |||
| SW1417 | Growth Inhibition Assay | IC50=0.73593 μM | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | IC50=0.73864 μM | SANGER | |||
| CAL-54 | Growth Inhibition Assay | IC50=0.7403 μM | SANGER | |||
| Saos-2 | Growth Inhibition Assay | IC50=0.74584 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=0.74806 μM | SANGER | |||
| LS-513 | Growth Inhibition Assay | IC50=0.74908 μM | SANGER | |||
| PA-1 | Growth Inhibition Assay | IC50=0.74968 μM | SANGER | |||
| HCC38 | Growth Inhibition Assay | IC50=0.74984 μM | SANGER | |||
| DMS-273 | Growth Inhibition Assay | IC50=0.75456 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=0.76262 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=0.77355 μM | SANGER | |||
| UACC-62 | Growth Inhibition Assay | IC50=0.77553 μM | SANGER | |||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.78211 μM | SANGER | |||
| SW982 | Growth Inhibition Assay | IC50=0.78432 μM | SANGER | |||
| 8305C | Growth Inhibition Assay | IC50=0.78939 μM | SANGER | |||
| SW48 | Growth Inhibition Assay | IC50=0.7924 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=0.79651 μM | SANGER | |||
| J82 | Growth Inhibition Assay | IC50=0.80487 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=0.81349 μM | SANGER | |||
| HEC-1 | Growth Inhibition Assay | IC50=0.81371 μM | SANGER | |||
| AU565 | Growth Inhibition Assay | IC50=0.8244 μM | SANGER | |||
| KYSE-520 | Growth Inhibition Assay | IC50=0.82636 μM | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | IC50=0.83474 μM | SANGER | |||
| AN3-CA | Growth Inhibition Assay | IC50=0.83711 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=0.84484 μM | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | IC50=0.84556 μM | SANGER | |||
| HN | Growth Inhibition Assay | IC50=0.84591 μM | SANGER | |||
| SiHa | Growth Inhibition Assay | IC50=0.85882 μM | SANGER | |||
| C-33-A | Growth Inhibition Assay | IC50=0.86185 μM | SANGER | |||
| A673 | Growth Inhibition Assay | IC50=0.86536 μM | SANGER | |||
| HSC-2 | Growth Inhibition Assay | IC50=0.87334 μM | SANGER | |||
| LN-405 | Growth Inhibition Assay | IC50=0.87731 μM | SANGER | |||
| HOS | Growth Inhibition Assay | IC50=0.87995 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=0.88097 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=0.88602 μM | SANGER | |||
| HT-29 | Growth Inhibition Assay | IC50=0.89417 μM | SANGER | |||
| NCI-H292 | Growth Inhibition Assay | IC50=0.89777 μM | SANGER | |||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.90316 μM | SANGER | |||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.90578 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=0.90943 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=0.90984 μM | SANGER | |||
| SW1088 | Growth Inhibition Assay | IC50=0.91552 μM | SANGER | |||
| NCI-H1048 | Growth Inhibition Assay | IC50=0.91852 μM | SANGER | |||
| A431 | Growth Inhibition Assay | IC50=0.92452 μM | SANGER | |||
| SW1783 | Growth Inhibition Assay | IC50=0.93251 μM | SANGER | |||
| NCI-H2452 | Growth Inhibition Assay | IC50=0.93557 μM | SANGER | |||
| OAW-42 | Growth Inhibition Assay | IC50=0.93665 μM | SANGER | |||
| HuO-3N1 | Growth Inhibition Assay | IC50=0.94092 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=0.94127 μM | SANGER | |||
| SW1573 | Growth Inhibition Assay | IC50=0.94227 μM | SANGER | |||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.94237 μM | SANGER | |||
| HCC1187 | Growth Inhibition Assay | IC50=0.96749 μM | SANGER | |||
| HCE-4 | Growth Inhibition Assay | IC50=0.9696 μM | SANGER | |||
| HPAF-II | Growth Inhibition Assay | IC50=0.97028 μM | SANGER | |||
| MEL-HO | Growth Inhibition Assay | IC50=0.97945 μM | SANGER | |||
| LCLC-103H | Growth Inhibition Assay | IC50=0.98027 μM | SANGER | |||
| CAL-33 | Growth Inhibition Assay | IC50=0.98378 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=0.98462 μM | SANGER | |||
| BFTC-905 | Growth Inhibition Assay | IC50=0.98473 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=0.98592 μM | SANGER | |||
| RCM-1 | Growth Inhibition Assay | IC50=0.99258 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=1.00412 μM | SANGER | |||
| NCI-H2030 | Growth Inhibition Assay | IC50=1.01813 μM | SANGER | |||
| SCC-4 | Growth Inhibition Assay | IC50=1.01859 μM | SANGER | |||
| KYSE-410 | Growth Inhibition Assay | IC50=1.0352 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=1.03971 μM | SANGER | |||
| S-117 | Growth Inhibition Assay | IC50=1.04 μM | SANGER | |||
| GAK | Growth Inhibition Assay | IC50=1.05075 μM | SANGER | |||
| KYSE-450 | Growth Inhibition Assay | IC50=1.05336 μM | SANGER | |||
| M059J | Growth Inhibition Assay | IC50=1.06828 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=1.07773 μM | SANGER | |||
| NCI-H1651 | Growth Inhibition Assay | IC50=1.09352 μM | SANGER | |||
| KMOE-2 | Growth Inhibition Assay | IC50=1.10973 μM | SANGER | |||
| SN12C | Growth Inhibition Assay | IC50=1.11785 μM | SANGER | |||
| SW900 | Growth Inhibition Assay | IC50=1.12251 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=1.12291 μM | SANGER | |||
| HO-1-N-1 | Growth Inhibition Assay | IC50=1.14353 μM | SANGER | |||
| BHT-101 | Growth Inhibition Assay | IC50=1.14714 μM | SANGER | |||
| 639-V | Growth Inhibition Assay | IC50=1.1667 μM | SANGER | |||
| RVH-421 | Growth Inhibition Assay | IC50=1.19347 μM | SANGER | |||
| SW780 | Growth Inhibition Assay | IC50=1.19515 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=1.19819 μM | SANGER | |||
| U-87-MG | Growth Inhibition Assay | IC50=1.21334 μM | SANGER | |||
| TE-1 | Growth Inhibition Assay | IC50=1.21367 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=1.21418 μM | SANGER | |||
| MKN7 | Growth Inhibition Assay | IC50=1.21478 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=1.21773 μM | SANGER | |||
| NCI-H1693 | Growth Inhibition Assay | IC50=1.22758 μM | SANGER | |||
| KGN | Growth Inhibition Assay | IC50=1.23359 μM | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | IC50=1.23525 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=1.24343 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=1.26666 μM | SANGER | |||
| SAS | Growth Inhibition Assay | IC50=1.26672 μM | SANGER | |||
| BT-549 | Growth Inhibition Assay | IC50=1.26782 μM | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | IC50=1.2864 μM | SANGER | |||
| BxPC-3 | Growth Inhibition Assay | IC50=1.30672 μM | SANGER | |||
| SCH | Growth Inhibition Assay | IC50=1.32503 μM | SANGER | |||
| GMS-10 | Growth Inhibition Assay | IC50=1.34551 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=1.37564 μM | SANGER | |||
| NCI-H520 | Growth Inhibition Assay | IC50=1.38168 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=1.39051 μM | SANGER | |||
| HuH-7 | Growth Inhibition Assay | IC50=1.39501 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=1.39986 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=1.40231 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=1.41187 μM | SANGER | |||
| NCI-H650 | Growth Inhibition Assay | IC50=1.41795 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=1.41954 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=1.42018 μM | SANGER | |||
| HCT-116 | Growth Inhibition Assay | IC50=1.42176 μM | SANGER | |||
| NCI-H1573 | Growth Inhibition Assay | IC50=1.42257 μM | SANGER | |||
| NCI-H358 | Growth Inhibition Assay | IC50=1.43128 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=1.44319 μM | SANGER | |||
| KP-4 | Growth Inhibition Assay | IC50=1.46151 μM | SANGER | |||
| LK-2 | Growth Inhibition Assay | IC50=1.46382 μM | SANGER | |||
| EFM-19 | Growth Inhibition Assay | IC50=1.48104 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=1.48613 μM | SANGER | |||
| A549 | Growth Inhibition Assay | IC50=1.48833 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=1.49026 μM | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | IC50=1.4938 μM | SANGER | |||
| NCI-H2170 | Growth Inhibition Assay | IC50=1.52313 μM | SANGER | |||
| NCI-H460 | Growth Inhibition Assay | IC50=1.52961 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=1.53706 μM | SANGER | |||
| KYSE-510 | Growth Inhibition Assay | IC50=1.5825 μM | SANGER | |||
| YKG-1 | Growth Inhibition Assay | IC50=1.58328 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=1.60227 μM | SANGER | |||
| MDA-MB-231 | Growth Inhibition Assay | IC50=1.6038 μM | SANGER | |||
| HT55 | Growth Inhibition Assay | IC50=1.60591 μM | SANGER | |||
| NCI-H1793 | Growth Inhibition Assay | IC50=1.61345 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=1.63456 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=1.69256 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=1.69983 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=1.70067 μM | SANGER | |||
| ME-180 | Growth Inhibition Assay | IC50=1.71785 μM | SANGER | |||
| BT-20 | Growth Inhibition Assay | IC50=1.72407 μM | SANGER | |||
| A498 | Growth Inhibition Assay | IC50=1.72963 μM | SANGER | |||
| UMC-11 | Growth Inhibition Assay | IC50=1.76749 μM | SANGER | |||
| EC-GI-10 | Growth Inhibition Assay | IC50=1.77556 μM | SANGER | |||
| NCI-H630 | Growth Inhibition Assay | IC50=1.78642 μM | SANGER | |||
| EGI-1 | Growth Inhibition Assay | IC50=1.80267 μM | SANGER | |||
| 22RV1 | Growth Inhibition Assay | IC50=1.80853 μM | SANGER | |||
| LS-123 | Growth Inhibition Assay | IC50=1.81214 μM | SANGER | |||
| OAW-28 | Growth Inhibition Assay | IC50=1.84746 μM | SANGER | |||
| CaR-1 | Growth Inhibition Assay | IC50=1.8707 μM | SANGER | |||
| HT | Growth Inhibition Assay | IC50=1.87342 μM | SANGER | |||
| BCPAP | Growth Inhibition Assay | IC50=1.88676 μM | SANGER | |||
| RMG-I | Growth Inhibition Assay | IC50=1.90787 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=1.90932 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=1.92035 μM | SANGER | |||
| SCC-9 | Growth Inhibition Assay | IC50=1.99105 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=2.00154 μM | SANGER | |||
| KU-19-19 | Growth Inhibition Assay | IC50=2.00372 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=2.00898 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=2.04059 μM | SANGER | |||
| MDA-MB-453 | Growth Inhibition Assay | IC50=2.05442 μM | SANGER | |||
| BPH-1 | Growth Inhibition Assay | IC50=2.07098 μM | SANGER | |||
| DK-MG | Growth Inhibition Assay | IC50=2.08603 μM | SANGER | |||
| Capan-2 | Growth Inhibition Assay | IC50=2.10041 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=2.12541 μM | SANGER | |||
| DOK | Growth Inhibition Assay | IC50=2.13147 μM | SANGER | |||
| YAPC | Growth Inhibition Assay | IC50=2.15307 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=2.17015 μM | SANGER | |||
| EFO-21 | Growth Inhibition Assay | IC50=2.17788 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=2.19271 μM | SANGER | |||
| RH-18 | Growth Inhibition Assay | IC50=2.19369 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=2.19596 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=2.29973 μM | SANGER | |||
| RPMI-2650 | Growth Inhibition Assay | IC50=2.32659 μM | SANGER | |||
| HMV-II | Growth Inhibition Assay | IC50=2.33868 μM | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | IC50=2.34603 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=2.38204 μM | SANGER | |||
| L-428 | Growth Inhibition Assay | IC50=2.38794 μM | SANGER | |||
| U-118-MG | Growth Inhibition Assay | IC50=2.39805 μM | SANGER | |||
| RO82-W-1 | Growth Inhibition Assay | IC50=2.43727 μM | SANGER | |||
| NCI-H2291 | Growth Inhibition Assay | IC50=2.46994 μM | SANGER | |||
| SK-OV-3 | Growth Inhibition Assay | IC50=2.50249 μM | SANGER | |||
| NCI-H441 | Growth Inhibition Assay | IC50=2.50305 μM | SANGER | |||
| NCI-H2009 | Growth Inhibition Assay | IC50=2.52934 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=2.53747 μM | SANGER | |||
| PANC-10-05 | Growth Inhibition Assay | IC50=2.61116 μM | SANGER | |||
| CAL-85-1 | Growth Inhibition Assay | IC50=2.66161 μM | SANGER | |||
| PC-3 | Growth Inhibition Assay | IC50=2.66611 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=2.67374 μM | SANGER | |||
| D-502MG | Growth Inhibition Assay | IC50=2.70406 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=2.71627 μM | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | IC50=2.71949 μM | SANGER | |||
| D-247MG | Growth Inhibition Assay | IC50=2.73756 μM | SANGER | |||
| CAL-39 | Growth Inhibition Assay | IC50=2.86389 μM | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | IC50=2.88431 μM | SANGER | |||
| NB7 | Growth Inhibition Assay | IC50=2.92139 μM | SANGER | |||
| NCI-H1437 | Growth Inhibition Assay | IC50=2.92257 μM | SANGER | |||
| RD | Growth Inhibition Assay | IC50=2.99939 μM | SANGER | |||
| TCCSUP | Growth Inhibition Assay | IC50=3.02636 μM | SANGER | |||
| MKN28 | Growth Inhibition Assay | IC50=3.03463 μM | SANGER | |||
| NCI-H596 | Growth Inhibition Assay | IC50=3.0671 μM | SANGER | |||
| SW948 | Growth Inhibition Assay | IC50=3.09693 μM | SANGER | |||
| WM-115 | Growth Inhibition Assay | IC50=3.11827 μM | SANGER | |||
| HCC1954 | Growth Inhibition Assay | IC50=3.12141 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=3.18474 μM | SANGER | |||
| SW13 | Growth Inhibition Assay | IC50=3.2326 μM | SANGER | |||
| OE19 | Growth Inhibition Assay | IC50=3.28489 μM | SANGER | |||
| HT-1197 | Growth Inhibition Assay | IC50=3.29179 μM | SANGER | |||
| HLE | Growth Inhibition Assay | IC50=3.3281 μM | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | IC50=3.44761 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=3.52417 μM | SANGER | |||
| SK-MEL-3 | Growth Inhibition Assay | IC50=3.53214 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=3.562 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=3.57986 μM | SANGER | |||
| KLE | Growth Inhibition Assay | IC50=3.59867 μM | SANGER | |||
| NCI-H2052 | Growth Inhibition Assay | IC50=3.60009 μM | SANGER | |||
| NCI-H1838 | Growth Inhibition Assay | IC50=3.81119 μM | SANGER | |||
| NCI-H1623 | Growth Inhibition Assay | IC50=4.01396 μM | SANGER | |||
| SCC-25 | Growth Inhibition Assay | IC50=4.23597 μM | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | IC50=4.25191 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=4.29271 μM | SANGER | |||
| LU-99A | Growth Inhibition Assay | IC50=4.31345 μM | SANGER | |||
| CAMA-1 | Growth Inhibition Assay | IC50=4.352 μM | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | IC50=4.41913 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=4.45528 μM | SANGER | |||
| BEN | Growth Inhibition Assay | IC50=4.52362 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=4.54871 μM | SANGER | |||
| CAL-27 | Growth Inhibition Assay | IC50=4.71694 μM | SANGER | |||
| G-401 | Growth Inhibition Assay | IC50=4.83841 μM | SANGER | |||
| CAL-120 | Growth Inhibition Assay | IC50=4.84991 μM | SANGER | |||
| DMS-114 | Growth Inhibition Assay | IC50=5.14506 μM | SANGER | |||
| KYSE-70 | Growth Inhibition Assay | IC50=5.14859 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=5.29782 μM | SANGER | |||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=5.44014 μM | SANGER | |||
| NCI-H2029 | Growth Inhibition Assay | IC50=5.48022 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=5.66889 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=5.70345 μM | SANGER | |||
| MDA-MB-415 | Growth Inhibition Assay | IC50=5.7081 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=5.74182 μM | SANGER | |||
| SK-MEL-24 | Growth Inhibition Assay | IC50=5.74564 μM | SANGER | |||
| HUTU-80 | Growth Inhibition Assay | IC50=5.75333 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=5.77563 μM | SANGER | |||
| IGR-1 | Growth Inhibition Assay | IC50=5.86894 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=6.24585 μM | SANGER | |||
| COLO-680N | Growth Inhibition Assay | IC50=6.39403 μM | SANGER | |||
| NB12 | Growth Inhibition Assay | IC50=6.79722 μM | SANGER | |||
| SNU-449 | Growth Inhibition Assay | IC50=6.99591 μM | SANGER | |||
| D-542MG | Growth Inhibition Assay | IC50=7.12299 μM | SANGER | |||
| COLO-792 | Growth Inhibition Assay | IC50=7.87127 μM | SANGER | |||
| NCI-H810 | Growth Inhibition Assay | IC50=8.02984 μM | SANGER | |||
| T47D | Growth Inhibition Assay | IC50=8.16024 μM | SANGER | |||
| Calu-3 | Growth Inhibition Assay | IC50=8.28886 μM | SANGER | |||
| COLO-741 | Growth Inhibition Assay | IC50=8.93093 μM | SANGER | |||
| LU-135 | Growth Inhibition Assay | IC50=9.03452 μM | SANGER | |||
| COLO-678 | Growth Inhibition Assay | IC50=9.28844 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=9.33919 μM | SANGER | |||
| SK-MEL-28 | Growth Inhibition Assay | IC50=9.53596 μM | SANGER | |||
| MFE-280 | Growth Inhibition Assay | IC50=10.0229 μM | SANGER | |||
| DBTRG-05MG | Growth Inhibition Assay | IC50=10.4369 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=10.5255 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=10.6852 μM | SANGER | |||
| C3A | Growth Inhibition Assay | IC50=12.3172 μM | SANGER | |||
| MHH-ES-1 | Growth Inhibition Assay | IC50=12.5284 μM | SANGER | |||
| LU-139 | Growth Inhibition Assay | IC50=12.6333 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=12.8771 μM | SANGER | |||
| MCF7 | Growth Inhibition Assay | IC50=13.2365 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=14.5461 μM | SANGER | |||
| HT-1376 | Growth Inhibition Assay | IC50=14.8582 μM | SANGER | |||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=15.1741 μM | SANGER | |||
| NCI-H2405 | Growth Inhibition Assay | IC50=15.4474 μM | SANGER | |||
| KYSE-150 | Growth Inhibition Assay | IC50=15.7611 μM | SANGER | |||
| SW837 | Growth Inhibition Assay | IC50=16.0124 μM | SANGER | |||
| LU-65 | Growth Inhibition Assay | IC50=19.726 μM | SANGER | |||
| JEG-3 | Growth Inhibition Assay | IC50=20.3577 μM | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | IC50=20.7836 μM | SANGER | |||
| SK-HEP-1 | Growth Inhibition Assay | IC50=21.5541 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=23.4086 μM | SANGER | |||
| MG-63 | Growth Inhibition Assay | IC50=23.7673 μM | SANGER | |||
| ECC10 | Growth Inhibition Assay | IC50=25.571 μM | SANGER | |||
| SW1463 | Growth Inhibition Assay | IC50=27.8316 μM | SANGER | |||
| JVM-2 | Growth Inhibition Assay | IC50=28.3248 μM | SANGER | |||
| HCT-15 | Growth Inhibition Assay | IC50=28.4192 μM | SANGER | |||
| CAL-72 | Growth Inhibition Assay | IC50=31.4912 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=32.8858 μM | SANGER | |||
| BT-474 | Growth Inhibition Assay | IC50=33.0843 μM | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | IC50=33.5145 μM | SANGER | |||
| Mo-T | Growth Inhibition Assay | IC50=37.3585 μM | SANGER | |||
| DU-145 | Growth Inhibition Assay | IC50=40.6295 μM | SANGER | |||
| NCI-H1666 | Growth Inhibition Assay | IC50=42.4488 μM | SANGER | |||
| IST-MES1 | Growth Inhibition Assay | IC50=46.4196 μM | SANGER | |||
| SW1116 | Growth Inhibition Assay | IC50=48.1756 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=48.5026 μM | SANGER | |||
| Click to View More Cell Line Experimental Data | ||||||
Biological Activity
| Description | AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1. | ||||
|---|---|---|---|---|---|
| Targets |
|
| In vitro | ||||
| In vitro | AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and Ki of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. [1] AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM. [2] | |||
|---|---|---|---|---|
| Kinase Assay | Chk1 Kinase Assay | |||
| Recombinant human Chk1 is expressed as a glutathione S-transferase fusion in insect cells using a baculovirus vector and purified by glutathione affinity chromatography. A synthetic peptide substrate (N-biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR) for Chk1 is synthesized. Final assay concentrations of peptide and ATP (cold + 40 nCi [33P]ATP) are 0.8 and 1 μM, respectively. Different concentrations of AZD7762, buffer containing peptide and chk1 kinase and ATP, are added sequentially to a 384-well assay plate. The plate is incubated for 2 hours, reaction is stopped by the addition of buffer containing EDTA and scintillation proximity assay beads, and plates are read using a TopCount reader. Data analysis is carried out to determinate a dose response (IC50). | ||||
| Cell Research | Cell lines | HT29, SW620 and MDA-MB-231 cells | ||
| Concentrations | Dissolved in DMSO, final concentration ~12.5 μM | |||
| Incubation Time | 20 or 48 hours | |||
| Method | For the checkpoint abrogation assay, HT29 cells are treated for 2 hours with camptothecin (topoisomerase I inhibitor; 0.07 μg/mL) to induce the G2 checkpoint. Cells are then treated for 20 hours with a 12-point titration of AZD7762 (12.5 μM to 6 nM) plus nocodazole. Cells are fixed with 3.7% formaldehyde for 1 hour, permeabilized with PBS containing 0.05% Triton X, and incubated with anti-phH3 antibody for 1 hour followed by Alexa Fluor 488 anti-rabbit and Hoechst stain for 1 hour. Mitotic index is determined on the ArrayScan and expressed as the percentage of cells undergoing mitosis. For the potentiation assays, SW620 or MDA-MB-231 cells are dosed for 24 hours with a 9-point titration of gemcitabine ranging from 0.01 to 100 nM with a constant dose of AZD7762 (300 nM). After 24 hours, medium is removed and AZD7762 alone is added back to the wells for an additional 24 hours. Cells are then incubated in AZD7762-free medium for an additional 72 hours. The effect on cell proliferation is determined by MTT. | |||
| Experimental Result Images | Methods | Biomarkers | Images | PMID |
| Western blot | pChk1 / Chk1 / Wee1 / p21 / p53 |
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29963769 | |
| Growth inhibition assay | Cell viability |
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23715154 | |
| In Vivo | ||
| In vivo | AZD7762 alone at 25 mg/kg shows little antitumor activity in the H460-DNp53 xenograft mice and SW620 xenograft mice, but when administrated in combination with gemcitabine (60 mg/kg), AZD7762 shows significant antitumor efficacy in the two xenografts mice with a log cell kill of 0.9 or percent treated/control (%T/C) of 26 even at low dose of 12.5 mg. Dosing of AZD7762 in combination with gemcitabine (10 mg/kg) in the H460-DNp53 xenograft rat inhibits the tumor volume in a dose-dependent manner with the %T/C values of 48 and 32 for 10 and 20 mg/kg AZD7762, respectively. AZD7762 (25 mg/kg) in combination with irinotecan (25 or 50 mg/kg) causes complete tumor regression in the SW620 xenograft mice with the %T/C increasing significantly to -66% and -67%, respectively. [1] | |
|---|---|---|
| Animal Research | Animal Models | Male NCr mice implanted s.c. with H460-DNp53 cells or SW620, and male rnu rats implanted s.c. with H460-DNp53 cells |
| Dosages | ~25 mg/kg | |
| Administration | Injection i.v. | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT00937664 | Terminated | Cancer|Solid Tumors|Advanced Solid Malignancies | AstraZeneca | July 2009 | Phase 1 |
| NCT00473616 | Terminated | Advanced Solid Tumors|Cancer|Advanced Solid Malignancies | AstraZeneca | May 2007 | Phase 1 |
| NCT00413686 | Completed | Solid Tumors | AstraZeneca | December 2006 | Phase 1 |
Chemical lnformation & Solubility
| Molecular Weight | 362.42 | Formula | C17H19FN4O2S |
| CAS No. | 860352-01-8 | SDF | Download AZD7762 SDF |
| Smiles | C1CC(CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N | ||
| Storage (From the date of receipt) | |||
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In vitro |
DMSO : 73 mg/mL ( (201.42 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Water : Insoluble Ethanol : Insoluble |
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In vivo Add solvents to the product individually and in order. |
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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Frequently Asked Questions
Question 1:
If I want to use the inhibitor for i.p. injection, can I use DMSO to dissolve it?
Answer:
Since DMSO has low toxicity with i.p. injection, hydroxyproplyl-β-cyclodextrin is consider a safer co-solvent in compound formulation. In a previous literature report, 11.3% hydroxyproplyl-β-cyclodextrin was used to formulate this compound for i.v. injection.
Chk Signaling Pathway Map
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