Home Metabolism Carbohydrate Metabolism chemical Acarbose For research use only.

Acarbose

Synonyms: BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421

Acarbose(BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421) is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.

Acarbose Chemical Structure

Acarbose Chemical Structure

CAS: 56180-94-0

Selleck's Acarbose has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 100.00%
100.00

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Biological Activity

Description Acarbose(BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421) is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.
Targets
alpha-glucosidase [1]
In vitro
In vitro

Acarbose reversibly inhibits intestinal alpha-glucosidases, enzymes responsible for the metabolism of complex carbohydrates into absorbable monosaccharide units.[1]
In Vivo
In vivo

Acarbose reduces the absorption of monosaccharides derived from dietary carbohydrates, which play an important role in the metabolism and toxicity of some chemical compounds. Acarbose alone potentiates carbon tetrachloride (CCl4) andacetaminophen (AP) hepatotoxicity, as evidenced by significantly increased levels of both alanine transaminase (ALT) and aspartate transaminase (AST) in the plasma of rats pretreated with acarbose. [2] Acarbose treatment suppresses weight gain and the development of hepatic steatosis in sqstm1 gene knockout mice. Acarbose treatment up-regulates hepatic expression of the pparalpha, ucp-2, and abca1 genes, as well as srebp1c, pparalpha, and ppargamma in adipose tissue. [3] Acarbose-treated rats have lower body weights at 3 months of age with unaltered food consumption, and a similar effect is seen with a high-fructose diet in the JCR:LA-corpulent rat. [4] Acarbose markedly improves postprandial hyperglycemia, postprandial insulin level, total cholesterol, triglyceride, and free fatty acid level in Goto-Kakizaki (GK) rats. Acarbose efficiently reduces the number of monocytes adherent to aortic endothelial layer, improves acetylcholine-dependent vasodilatation, and reduces intimal thickening of the aorta in GK rats. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05487859 Not yet recruiting Kidney Cancer University of Alabama at Birmingham November 1 2023 Phase 2
NCT04665570 Active not recruiting Type 2 Diabetes Mellitus Bayer December 21 2020 --
NCT04180813 Terminated Diabetes Mellitus Type 2 Boehringer Ingelheim March 4 2020 --
NCT02953093 Completed Aging Montefiore Medical Center August 30 2017 Phase 2
NCT02589353 Completed Healthy Volunteers Oregon State University April 21 2017 Phase 4
NCT02527239 Unknown status Pompe''s Disease Royal Brompton & Harefield NHS Foundation Trust|Genzyme a Sanofi Company September 2015 --

Chemical lnformation & Solubility

Molecular Weight 645.6 Formula

C25H43NO18
CAS No. 56180-94-0 SDF Download Acarbose SDF
Smiles CC1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)NC4C=C(C(C(C4O)O)O)CO
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 129 mg/mL ( (199.81 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 129 mg/mL

Ethanol : 8 mg/mL


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In vivo
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