Home Metabolism P450 (e.g. CYP17) inhibitor Alizarin For research use only.

Alizarin

Synonyms: Anthraquinonic

Alizarin is a red coloring mordant dye extracted from the roots of madder plants (Rubia tinctorum L). Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2, and CYP1B1 with IC50 of 6.2 μM, 10.0 μM, and 2.7 μM, respectively in an enzymatic assay. There are also literature reports Alizarin increases the CYP1A1 enzymatic activity and acts as an agonist to the AHR receptor in HepG2 cells.

Alizarin Chemical Structure

Alizarin Chemical Structure

CAS: 72-48-0

Selleck's Alizarin has been cited by 4 publications

Purity & Quality Control

Batch: S252601 DMSO] 48 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.19%
99.19

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Biological Activity

Description Alizarin is a red coloring mordant dye extracted from the roots of madder plants (Rubia tinctorum L). Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2, and CYP1B1 with IC50 of 6.2 μM, 10.0 μM, and 2.7 μM, respectively in an enzymatic assay. There are also literature reports Alizarin increases the CYP1A1 enzymatic activity and acts as an agonist to the AHR receptor in HepG2 cells.
Targets
CYP1B1 [1] CYP1A1 [1] CYP1A2 [1]
2.7 μM 6.2 μM 10.0 μM
In vitro
In vitro Alizarin weakly inhibits CYP2A6 and CYP2E1. Alizarin shows competitive inhibition against CYP1B1 with Ki of 0.5 μM. Alizarin reduces the mutagenicity of MeIQx, which induced by each CYP1A2 or CYP1B1, while does not effectively reduce the mutation induced by B[a]P. [1] Alizarin exhibits antioxidants against iodophenol-derived phenoxyl radicals, superoxide anion radicals and lipid peroxidation in rat liver microsomes. [2]
In Vivo
In vivo Alizarin also reduces the hepatic content of thiobarbituric acid-reactive substances and the serum level of alanine aminotransferase in poisoned animals. [2]

Chemical lnformation & Solubility

Molecular Weight 240.21 Formula

C14H8O4
CAS No. 72-48-0 SDF Download Alizarin SDF
Smiles C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 48 mg/mL ( (199.82 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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