Home Metabolism Decarboxylase inhibitor Benserazide HCl For research use only.

Benserazide HCl

Synonyms: Ro-4-4602

Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.Solutions are unstable and should be fresh-prepared.

Benserazide HCl Chemical Structure

Benserazide HCl Chemical Structure

CAS: 14919-77-8

Selleck's Benserazide HCl has been cited by 4 publications

Purity & Quality Control

Batch: Purity: 99.95%
99.95

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Biological Activity

Description Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.Solutions are unstable and should be fresh-prepared.
Targets
aromatic-L-amino-acid decarboxylase [1] DOPA decarboxylase [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01327261 Completed Healthy Volunteers University of Buenos Aires|Laboratorios Phoenix S.A.I.C.y F. August 2009 Phase 4
NCT00203164 Completed Parkinson''s Disease Teva Branded Pharmaceutical Products R&D Inc. May 2002 Phase 3

Chemical lnformation & Solubility

Molecular Weight 293.7 Formula

C10H15N3O5.HCl
CAS No. 14919-77-8 SDF Download Benserazide HCl SDF
Smiles C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O.Cl
Storage (From the date of receipt) 1 year -80 powder（in dark and seal） Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

DMSO : 59 mg/mL ( (200.88 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 59 mg/mL

Ethanol : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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