Home Endocrinology & Hormones Glucocorticoid Receptor agonist Betamethasone For research use only.

Betamethasone

Synonyms: NSC-39470, SCH-4831

Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.

Betamethasone Chemical Structure

Betamethasone Chemical Structure

CAS: 378-44-9

Selleck's Betamethasone has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.96%
99.96

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Biological Activity

Description Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
Targets
Glucocorticoid receptor [1]
In vitro
In vitro Betamethasone has a specific affinity for type II glucocorticoid receptors which are present in most brain regions. [1]
In Vivo
In vivo Betamethasone has direct vasoconstrictor effects on peripheral femoral resistance vessels in late gestation fetal sheep. Betamethasone exposure decreases cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 hours of infusion in sheep. [1] Betamethasone reduces the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induces the expression of IL-10 in the brain, all of which correlate with the changes of pain thresholds in rats. [2] Betamethasone exposure reduces synaptophysin-LI in the frontal neocortex, caudate putamen and hippocampus by 46.9%, 41.0% and 55.4%, respectively, that is not accompanied by irreversible neuronal damage in the fetal sheep brain. [3] Betamethasone modestly increases cytidylyltransferase (CT) mRNA, but does not alter the levels of immunoreactive enzyme in adult rat lung. Betamethasone decreases the activities of the sphingomyelin hydrolases: acid sphingomyelinase by 33% and of alkaline ceramidase by 21%. [4] Betamethasone injected at the time of nerve injury partially inhibits the development of neuropathic hyperalgesia and reduces the subsequent elevated levels of pro-inflammatory cytokines in the brain of rats, while stimulating the expression of the anti-inflammatory cytokine IL-10. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04770805 Recruiting Sacral Myelomeningocele|Neural Tube Defects|Spina Bifida Assistance Publique - Hôpitaux de Paris April 16 2021 Not Applicable
NCT03210545 Unknown status Addison Disease Göteborg University March 2 2021 Phase 4
NCT04645979 Completed Rhinitis Allergic Bayer November 11 2020 --

Chemical lnformation & Solubility

Molecular Weight 392.46 Formula

C22H29FO5
CAS No. 378-44-9 SDF Download Betamethasone SDF
Smiles CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 79 mg/mL ( (201.29 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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