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Bleomycin sulfate

Synonyms: NSC125066 sulfate

Bleomycin sulfate is a glycopeptide antibiotic and a DNA synthesis inhibitor, as well as an anticancer agent for squamous cell carcinomas (SCC) with an IC50 of 4 nM in UT-SCC-19A cells. Bleomycin sulfate is a DNA synthesis inhibitor.

Bleomycin sulfate Chemical Structure

Bleomycin sulfate Chemical Structure

CAS: 9041-93-4

Selleck's Bleomycin sulfate has been cited by 111 publications

Purity & Quality Control

Batch: Purity: 99.97%
99.97

Products often used together with Bleomycin sulfate

Lomustine

Bleomycin (NSC125066) sulfate and Lomustine (CCNU-NSC79037) combination are beneficial for the treatment of metastatic testicular carcinoma.

Sonntag RW, et al. Cancer Chemother Rep. 1975 Mar-Apr;59(2 Pt 1):429-31.

Cisplatin

Bleomycin sulfateand Cisplatin combo inhibits DNA synthesis, causing cell death in mouse embryo fibroblast.

Hussain SS, et al. Chemotherapy. 1988;34(6):504-11.

Carboplatin

Bleomycin sulfateand Carboplatin combo inhibits DNA synthesis, causing cell death in mouse embryo fibroblast.

Hussain SS, et al. Chemotherapy. 1988;34(6):504-11.

Doxorubicin

Bleomycin (NSC125066) sulfate and Doxorubicin (Adriamycin) combination are effective in chemically induced tumors of the forestomach and the urinary bladder in Sprague Dawley rats.

Tormey DC, et al. Cancer Chemother Rep. 1973 Nov-Dec;57(4):413-8.

Vinblastine sulfate

Bleomycin (NSC125066) sulfate and Vinblastine combination are effective in patients with unresectable non-small-cell lung cancer (NSCLC).

Chlebowski RT, et al. J Clin Oncol. 1990 Jan;8(1):9-15.

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Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
F98 Growth Inhibition Assay 0–1000 μm 24 h  inhibits cell growth dose dependently 26088711
POLK WT Growth Inhibition Assay IC50=11.7 ± 1.7 μM 26031400
POLK KO Growth Inhibition Assay IC50=4.03 ± 1.92 μM 26031400
POLK CD Growth Inhibition Assay IC50=5.59 ± 1.00 μM 26031400
RLE/Abca3 Function Assay 0.4 μM 144 h induces a morphological change from epithelial-like morphology to a wide, spread-out morphology  25760538
PMCs Function Assay 0.1–2 μg/ml 24 h causes a dose-dependent increase in the protein level of collagen-I  25595642
PMCs Function Assay 0.2 μg/ml 24–72 h induces increases in vimentin and α-SMA protein 25595642
PMCs Function Assay 0.2 μg/ml 72 h induces decreases in cytokeratin-8 and E-cadherin protein 25595642
PMCs Function Assay 0.2 μg/ml 12/24/48 h increases cell migration 25595642
IMR-32 Growth Inhibition Assay 7.5−120 µg/ml 12−48 h IC50=60 µg/ml at the end of 24 hrs of incubation 25536345
HT1080 Growth Inhibition Assay 1 μM 24 h  leads to a G2/M delay 25518961
HT1080 Function Assay 1 μM 24 h  induces a potent global DNA damage response 25518961
HDFn Cytotoxicity Assay 72 h IC50=9.31%  25276792
THP-1 Cytotoxicity Assay 72 h IC50=4.77% 25276792
HT-29 Cytotoxicity Assay 72 h IC50=11.49% 25276792
HCT116  Cytotoxicity Assay 72 h IC50=11.34% 25276792
A431 Growth Inhibition Assay 50-200 IU 48 h inhibits cell growth dose dependently 25101299
T24 Growth Inhibition Assay 50-200 IU 48 h inhibits cell growth dose dependently 25101299
AY-27  Growth Inhibition Assay 50-200 IU 48 h inhibits cell growth dose dependently 25101299
A549 Function Assay 1 µg/mL  0-48 h increases the expression of OPN mRNA 24963635
MLE12 Function Assay 1 µg/mL  0-48 h increases the expression of OPN mRNA 24963635
Jurkat Growth Inhibition Assay 20 μm 24 h  arrests the cell cycle at the G2 phase 24916893
HeLa  Growth Inhibition Assay IC50=10.2 μM 24732397
C18-4 Growth Inhibition Assay 0-100 μM inhibits cell growth dose dependently 24571982
BMG-1  Growth Inhibition Assay 40/80 μg/m 3 h inhibits cell growth dose dependently 23906726
A459 Apoptosis Assay 10 mU 48 h induces apoptosis 23902766
MOCK Apoptosis Assay 10 mU 48 h induces apoptosis 23902766
MMP1 Apoptosis Assay 10 mU 48 h induces apoptosis 23902766
A549 Growth Inhibition Assay 200 μM 24 h  decreases cell viability significantly 23805793
HCT-116 Apoptosis Assay 3/7.5/15 μg/ml 48 h reduces the level of BLH at high concentration 23708668
HeLa Apoptosis Assay 3/7.5/15 μg/ml 48 h reduces the level of BLH at high concentration 23708668
HCT116 Growth Inhibition Assay 0-100 μg/ml 48 h inhibits cell growth dose dependently 23518201
NCM460 Growth Inhibition Assay 0-100 μg/ml 48 h inhibits cell growth dose dependently 23518201
NT2  Growth Inhibition Assay 24 h  LD50=400 µg/ml 23386420
NT2  Growth Inhibition Assay 48 h LD50=100 µg/ml 23386420
NT2  Growth Inhibition Assay 72 h LD50=20 µg/ml 23386420
NT2  Apoptosis Assay 400 µg/ml 24 h  induces significant increases in caspase-3,8,9 activity  23386420
NTera-2 Function Assay 120 μg/ml 72 h significantly increases 8-isoprostane levels 22825355
NCCIT Function Assay 120 μg/ml 72 h significantly increases 8-isoprostane levels 22825355
NTera-2 Function Assay 120 μg/ml 72 h significantly increases TBARS levels 22825355
NCCIT Function Assay 120 μg/ml 72 h significantly increases TBARS levels 22825355
NCCIT Function Assay 120 μg/ml 72 h significantly decreases GSH levels 22825355
NTera-2 Function Assay 120 μg/ml 72 h significantly increases Protein carbonyl levels 22825355
NCCIT Function Assay 120 μg/ml 72 h significantly increases Protein carbonyl levels 22825355
NTera-2 Function Assay 120 μg/ml 72 h significantly increases LPO levels 22825355
NCCIT Function Assay 120 μg/ml 72 h significantly increases LPO levels 22825355
MDA-MB-468 Growth Inhibition Assay 0–200 μg/mL 24 h inhibits cell growth dose dependently 22819196
231-H2N Growth Inhibition Assay 0–200 μg/mL 24 h inhibits cell growth dose dependently 22819196
A549  Function Assay 200/400 μM results in a dose-responsive increase in ROS 22773697
A549  Function Assay 0-400 μM 2-48 h causes more mtDNA than nDNA damage 22773697
A549  Function Assay 100 μM  0–48 h causes caspase-3 activation 22773697
A549  Function Assay 100 μM  0–48 h causes PKD1 cleavage 22773697
A549  Function Assay 100 μM  0–48 h causes mitochondrial localization of Bax 22773697
A549  Function Assay 100 μM  0–48 h decreases MMP and ATP levels 22773697
MCF-7/Her-18  Growth Inhibition Assay 0.42-1700 μg/mL 24 h inhibits cell growth dose dependently 22621404
MCF-7 PDT/PCI Treatment 0.25 μg/ml. 1-4 h shows significant (P < 0.05) cytotoxic effect 22591284
MDA-MB-231 PDT/PCI Treatment 0.25 μg/ml. 1-4 h shows significant (P < 0.05) cytotoxic effect 22591284
MDA-MB-235  PDT/PCI Treatment 0.25 μg/ml. 1-4 h shows significant (P < 0.05) cytotoxic effect 22591284
MCF-7 Growth Inhibition Assay 0-2 μg/ml. 24/48 h EC50=1.2 μg/mL 22591284
NCCIT  Growth Inhibition Assay 20–140 μg/ml 72 h LD50=120 μg/ml  22562160
NCCIT  Function Assay 72 h significantly increases caspase-3 activity  22562160
NCCIT  Function Assay 72 h significantly increases caspase-8 activity  22562160
NCCIT  Function Assay 72 h significantly increases caspase-9 activity  22562160
NCCIT  Function Assay 72 h significantly increases BAX level 22562160
NCCIT  Function Assay 72 h significantly decreases the Bcl-2 content 22562160
NCCIT  Function Assay 72 h significantly decreases the Cyt-c level 22562160
HeLa Function Assay 30/70 μg/ml 24 h increases the mRNA levels of p53，ATM,p21 and GADD45 22487937
MCF-7  Function Assay 30/70 μg/ml 24 h increases the mRNA levels of p53，ATM,p21 and GADD45 22487937
HeLa Cytotoxicity Assay 30/70 μg/ml 24 h induces highly significant levels of fragmented DNA release into the cytoplasm 22487937
MCF-7  Cytotoxicity Assay 30/70 μg/ml 24 h induces highly significant levels of fragmented DNA release into the cytoplasm 22487937
NT2 Growth Inhibition Assay 100-600 μg/ml 24 h IC50=400 µg/ml 22469952
NT2 Function Assay 400 μg/ml 24 h significantly increases caspase-3,8,9 activity  22469952
NT2 Function Assay 400 μg/ml 24 h significantly increases BAX level 22469952
NT2 Function Assay 400 μg/ml 24 h significantly decreases Bcl-2 level 22469952
CHO Function Assay 2.5 μg/ml 18 h/6 d induces persistence of chromosome damage 22230195
Jurkat Growth Inhibition Assay 0-100 μg/ml 24 h arrests the cell cycle at the G2 phase 22223332
Jurkat Function Assay 30 μg/ml 24 h increases the protein levels of cyclins D3, A and B1 22223332
Jurkat Growth Inhibition Assay 0-100 μg/ml 24 h inhibits cell proliferation in a dose-dependent manner with an IC50 value of 100μg/mL 22223332
Jurkat Function Assay 30 μg/ml 24 h increases the effect of pycnidione on phosphorylation levels of histone H2A.X 22223332
U2OS EGFPnls Growth Inhibition Assay 0-2 μg/ml 24 h inhibits cell growth dose dependently 21811007
U2OS KuEnls Growth Inhibition Assay 0-2 μg/ml 24 h inhibits cell growth dose dependently 21811007
MCF-7 Growth Inhibition Assay 0-400 μM 72 h LC50=151.8 μM 21703291
MCF-7/Adr  Growth Inhibition Assay 0-400 μM 72 h LC50=58.5 μM  21703291
WI-38 Function Assay 0/40/80 μg/ml  3 h induces a concentration-dependent increase in the MN frequency  21599612
hBMSC Function Assay 0/40/80 μg/ml  3 h induces a concentration-dependent increase in the MN frequency  21599612
NCI-H23 Function Assay 0/40/80 μg/ml  3 h induces a concentration-dependent increase in the MN frequency  21599612
A-549 Function Assay 0/40/80 μg/ml  3 h induces a concentration-dependent increase in the MN frequency  21599612
PBL  Function Assay 0/40/80 μg/ml  3 h induces a concentration-dependent increase in the MN frequency  21599612
pol β −/− Growth Inhibition Assay 0.25-200 μg/ml 24 h decreases cell viability with increasing concentrations  21251944
pol β +/+ Growth Inhibition Assay 0.25-200 μg/ml 24 h decreases cell viability with increasing concentrations  21251944
pol β −/− Function Assay 0-2.5 μg/ml 2 h causes DNA damage 21251944
pol β +/+ Function Assay 0-2.5 μg/ml 2 h causes DNA damage 21251944
pol β −/− Function Assay 0-5 μg/ml 48 h causes micronucleus dose and time dependently 21251944
pol β +/+ Function Assay 0-5 μg/ml 48 h causes micronucleus dose and time dependently 21251944
TK6  Growth Inhibition Assay 25-150 μg/ml 96 h inhibits cell growth dose dependently 21081487
TK6  sLUC+Apn1 Growth Inhibition Assay 25-150 μg/ml 96 h inhibits cell growth dose dependently 21081487
TK6 sAPE1+Apn1 Growth Inhibition Assay 25-150 μg/ml 96 h significantly inhibits cell growth dose dependently 21081487
HCT116 Growth Inhibition Assay 25-150 μg/ml 96 h inhibits cell growth dose dependently 21081487
HCT116 sLUC+Apn1 Growth Inhibition Assay 25-150 μg/ml 96 h inhibits cell growth dose dependently 21081487
HCT116 sAPE1+Apn1 Growth Inhibition Assay 25-150 μg/ml 96 h significantly inhibits cell growth dose dependently 21081487
2SC/20 Function Assay 72 h IC50 = 0.517 μM 12431060
HET-SR-2SC-LNM Function Assay 72 h IC50 = 0.519 μM 12431060
HepG2 Growth Inhibition Assay GI50 = 1 μM 18068362
MCF-7 Function Assay 24 h IC50 = 53 μM 12477361
COLO-668 Growth Inhibition Assay IC50 = 0.0000218 μM SANGER
CAL-51 Growth Inhibition Assay IC50 = 0.000099 μM SANGER
A427 Growth Inhibition Assay IC50 = 0.000118 μM SANGER
RMG-I Growth Inhibition Assay IC50 = 0.0001319 μM SANGER
HUTU-80 Growth Inhibition Assay IC50 = 0.0001358 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50 = 0.0001391 μM SANGER
IST-SL2 Growth Inhibition Assay IC50 = 0.0001732 μM SANGER
CAL-85-1 Growth Inhibition Assay IC50 = 0.0001777 μM SANGER
SUP-T1 Growth Inhibition Assay IC50 = 0.000251 μM SANGER
HCC1937 Growth Inhibition Assay IC50 = 0.000254 μM SANGER
CAL-39 Growth Inhibition Assay IC50 = 0.0003147 μM SANGER
HAL-01 Growth Inhibition Assay IC50 = 0.0004527 μM SANGER
OVCAR-8 Growth Inhibition Assay IC50 = 0.0004763 μM SANGER
CESS Growth Inhibition Assay IC50 = 0.0005457 μM SANGER
NCI-H650 Growth Inhibition Assay IC50 = 0.0005873 μM SANGER
MKN28 Growth Inhibition Assay IC50 = 0.00108 μM SANGER
RS4-11 Growth Inhibition Assay IC50 = 0.001643 μM SANGER
MFH-ino Growth Inhibition Assay IC50 = 0.002646 μM SANGER
KYSE-150 Growth Inhibition Assay IC50 = 0.002647 μM SANGER
KGN Growth Inhibition Assay IC50 = 0.003712 μM SANGER
HOP-62 Growth Inhibition Assay IC50 = 0.004134 μM SANGER
LU-99A Growth Inhibition Assay IC50 = 0.00422 μM SANGER
RT4 Growth Inhibition Assay IC50 = 0.005856 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50 = 0.006293 μM SANGER
HCC2998 Growth Inhibition Assay IC50 = 0.006592 μM SANGER
GT3TKB Growth Inhibition Assay IC50 = 0.00685 μM SANGER
EW-16 Growth Inhibition Assay IC50 = 0.006853 μM SANGER
NKM-1 Growth Inhibition Assay IC50 = 0.007647 μM SANGER
HCC1806 Growth Inhibition Assay IC50 = 0.008543 μM SANGER
SW954 Growth Inhibition Assay IC50 = 0.009572 μM SANGER
MV-4-11 Growth Inhibition Assay IC50 = 0.009908 μM SANGER
LOUCY Growth Inhibition Assay IC50 = 0.009935 μM SANGER
KS-1 Growth Inhibition Assay IC50 = 0.01084 μM SANGER
NMC-G1 Growth Inhibition Assay IC50 = 0.01185 μM SANGER
REH Growth Inhibition Assay IC50 = 0.01339 μM SANGER
NCI-H2342 Growth Inhibition Assay IC50 = 0.01383 μM SANGER
BFTC-909 Growth Inhibition Assay IC50 = 0.01383 μM SANGER
EFM-19 Growth Inhibition Assay IC50 = 0.01477 μM SANGER
NCI-H1703 Growth Inhibition Assay IC50 = 0.01612 μM SANGER
BB30-HNC Growth Inhibition Assay IC50 = 0.01634 μM SANGER
NCI-H1734 Growth Inhibition Assay IC50 = 0.01742 μM SANGER
SF295 Growth Inhibition Assay IC50 = 0.02139 μM SANGER
MKN45 Growth Inhibition Assay IC50 = 0.02481 μM SANGER
ES1 Growth Inhibition Assay IC50 = 0.0267 μM SANGER
NEC8 Growth Inhibition Assay IC50 = 0.02685 μM SANGER
CTB-1 Growth Inhibition Assay IC50 = 0.02694 μM SANGER
5637 Growth Inhibition Assay IC50 = 0.02897 μM SANGER
SR Growth Inhibition Assay IC50 = 0.02967 μM SANGER
HCC38 Growth Inhibition Assay IC50 = 0.03124 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50 = 0.03255 μM SANGER
ES4 Growth Inhibition Assay IC50 = 0.03826 μM SANGER
MHH-ES-1 Growth Inhibition Assay IC50 = 0.04357 μM SANGER
LS-411N Growth Inhibition Assay IC50 = 0.05276 μM SANGER
HT-144 Growth Inhibition Assay IC50 = 0.05514 μM SANGER
BPH-1 Growth Inhibition Assay IC50 = 0.05909 μM SANGER
HMV-II Growth Inhibition Assay IC50 = 0.06974 μM SANGER
A375 Growth Inhibition Assay IC50 = 0.0711 μM SANGER
LoVo Growth Inhibition Assay IC50 = 0.07117 μM SANGER
COR-L23 Growth Inhibition Assay IC50 = 0.07548 μM SANGER
G-402 Growth Inhibition Assay IC50 = 0.07651 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50 = 0.07869 μM SANGER
MKN1 Growth Inhibition Assay IC50 = 0.07965 μM SANGER
LC-2-ad Growth Inhibition Assay IC50 = 0.08036 μM SANGER
ETK-1 Growth Inhibition Assay IC50 = 0.0805 μM SANGER
786-0 Growth Inhibition Assay IC50 = 0.08084 μM SANGER
SW13 Growth Inhibition Assay IC50 = 0.08162 μM SANGER
Daoy Growth Inhibition Assay IC50 = 0.08304 μM SANGER
G-361 Growth Inhibition Assay IC50 = 0.08831 μM SANGER
HCT-15 Growth Inhibition Assay IC50 = 0.0951 μM SANGER
ARH-77 Growth Inhibition Assay IC50 = 0.10452 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50 = 0.10753 μM SANGER
MEL-JUSO Growth Inhibition Assay IC50 = 0.10855 μM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50 = 0.11074 μM SANGER
769-P Growth Inhibition Assay IC50 = 0.1228 μM SANGER
MZ7-mel Growth Inhibition Assay IC50 = 0.1305 μM SANGER
KG-1 Growth Inhibition Assay IC50 = 0.13057 μM SANGER
23132-87 Growth Inhibition Assay IC50 = 0.13146 μM SANGER
ML-2 Growth Inhibition Assay IC50 = 0.13166 μM SANGER
BOKU Growth Inhibition Assay IC50 = 0.13698 μM SANGER
SW1573 Growth Inhibition Assay IC50 = 0.13715 μM SANGER
IMR-5 Growth Inhibition Assay IC50 = 0.13736 μM SANGER
PSN1 Growth Inhibition Assay IC50 = 0.13888 μM SANGER
LCLC-103H Growth Inhibition Assay IC50 = 0.14398 μM SANGER
IGROV-1 Growth Inhibition Assay IC50 = 0.14455 μM SANGER
CHP-212 Growth Inhibition Assay IC50 = 0.14774 μM SANGER
RH-1 Growth Inhibition Assay IC50 = 0.15221 μM SANGER
MFE-296 Growth Inhibition Assay IC50 = 0.15324 μM SANGER
NCI-H2170 Growth Inhibition Assay IC50 = 0.16242 μM SANGER
Saos-2 Growth Inhibition Assay IC50 = 0.17196 μM SANGER
LB996-RCC Growth Inhibition Assay IC50 = 0.17534 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50 = 0.18225 μM SANGER
PC-14 Growth Inhibition Assay IC50 = 0.18269 μM SANGER
ESS-1 Growth Inhibition Assay IC50 = 0.18744 μM SANGER
CAL-54 Growth Inhibition Assay IC50 = 0.19067 μM SANGER
A204 Growth Inhibition Assay IC50 = 0.20037 μM SANGER
639-V Growth Inhibition Assay IC50 = 0.21956 μM SANGER
A2780 Growth Inhibition Assay IC50 = 0.22019 μM SANGER
MZ1-PC Growth Inhibition Assay IC50 = 0.22434 μM SANGER
GDM-1 Growth Inhibition Assay IC50 = 0.22845 μM SANGER
HT-1080 Growth Inhibition Assay IC50 = 0.23357 μM SANGER
SK-CO-1 Growth Inhibition Assay IC50 = 0.24652 μM SANGER
SW1783 Growth Inhibition Assay IC50 = 0.24925 μM SANGER
PANC-10-05 Growth Inhibition Assay IC50 = 0.25606 μM SANGER
CAL-12T Growth Inhibition Assay IC50 = 0.25851 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50 = 0.26047 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50 = 0.27307 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50 = 0.27975 μM SANGER
GAMG Growth Inhibition Assay IC50 = 0.28935 μM SANGER
EW-13 Growth Inhibition Assay IC50 = 0.29208 μM SANGER
SW1710 Growth Inhibition Assay IC50 = 0.29533 μM SANGER
C3A Growth Inhibition Assay IC50 = 0.29644 μM SANGER
PANC-03-27 Growth Inhibition Assay IC50 = 0.31639 μM SANGER
H4 Growth Inhibition Assay IC50 = 0.32074 μM SANGER
NCI-H358 Growth Inhibition Assay IC50 = 0.37271 μM SANGER
ACHN Growth Inhibition Assay IC50 = 0.37463 μM SANGER
TE-8 Growth Inhibition Assay IC50 = 0.37669 μM SANGER
SK-MEL-30 Growth Inhibition Assay IC50 = 0.37688 μM SANGER
ES7 Growth Inhibition Assay IC50 = 0.37754 μM SANGER
DoTc2-4510 Growth Inhibition Assay IC50 = 0.37834 μM SANGER
C-4-II Growth Inhibition Assay IC50 = 0.38131 μM SANGER
SNU-449 Growth Inhibition Assay IC50 = 0.38851 μM SANGER
GB-1 Growth Inhibition Assay IC50 = 0.39011 μM SANGER
SF539 Growth Inhibition Assay IC50 = 0.39305 μM SANGER
MEG-01 Growth Inhibition Assay IC50 = 0.39549 μM SANGER
BE-13 Growth Inhibition Assay IC50 = 0.39872 μM SANGER
ES6 Growth Inhibition Assay IC50 = 0.40625 μM SANGER
SJRH30 Growth Inhibition Assay IC50 = 0.41411 μM SANGER
SK-HEP-1 Growth Inhibition Assay IC50 = 0.41493 μM SANGER
SCC-25 Growth Inhibition Assay IC50 = 0.41539 μM SANGER
SW982 Growth Inhibition Assay IC50 = 0.41743 μM SANGER
NALM-6 Growth Inhibition Assay IC50 = 0.42016 μM SANGER
NCI-H522 Growth Inhibition Assay IC50 = 0.42569 μM SANGER
PF-382 Growth Inhibition Assay IC50 = 0.42616 μM SANGER
C-33-A Growth Inhibition Assay IC50 = 0.43178 μM SANGER
GI-ME-N Growth Inhibition Assay IC50 = 0.44079 μM SANGER
RPMI-6666 Growth Inhibition Assay IC50 = 0.44505 μM SANGER
LOXIMVI Growth Inhibition Assay IC50 = 0.45232 μM SANGER
HCE-4 Growth Inhibition Assay IC50 = 0.45316 μM SANGER
DEL Growth Inhibition Assay IC50 = 0.47988 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50 = 0.49938 μM SANGER
HCC1395 Growth Inhibition Assay IC50 = 0.50094 μM SANGER
AGS Growth Inhibition Assay IC50 = 0.50253 μM SANGER
NCI-H1651 Growth Inhibition Assay IC50 = 0.5053 μM SANGER
ES5 Growth Inhibition Assay IC50 = 0.50539 μM SANGER
NCI-H2122 Growth Inhibition Assay IC50 = 0.50953 μM SANGER
BC-3 Growth Inhibition Assay IC50 = 0.521 μM SANGER
RKO Growth Inhibition Assay IC50 = 0.52424 μM SANGER
MHH-CALL-2 Growth Inhibition Assay IC50 = 0.53464 μM SANGER
HT-29 Growth Inhibition Assay IC50 = 0.5355 μM SANGER
SW48 Growth Inhibition Assay IC50 = 0.54612 μM SANGER
GOTO Growth Inhibition Assay IC50 = 0.54993 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50 = 0.5602 μM SANGER
HOS Growth Inhibition Assay IC50 = 0.56023 μM SANGER
EFO-27 Growth Inhibition Assay IC50 = 0.57104 μM SANGER
JVM-2 Growth Inhibition Assay IC50 = 0.57224 μM SANGER
SIG-M5 Growth Inhibition Assay IC50 = 0.58605 μM SANGER
HCC1569 Growth Inhibition Assay IC50 = 0.60449 μM SANGER
A101D Growth Inhibition Assay IC50 = 0.61972 μM SANGER
CAKI-1 Growth Inhibition Assay IC50 = 0.62043 μM SANGER
SBC-5 Growth Inhibition Assay IC50 = 0.62355 μM SANGER
RPMI-2650 Growth Inhibition Assay IC50 = 0.63315 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50 = 0.63656 μM SANGER
NCI-H64 Growth Inhibition Assay IC50 = 0.64101 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50 = 0.64336 μM SANGER
LXF-289 Growth Inhibition Assay IC50 = 0.64425 μM SANGER
HSC-3 Growth Inhibition Assay IC50 = 0.68829 μM SANGER
EB2 Growth Inhibition Assay IC50 = 0.69103 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50 = 0.71228 μM SANGER
KYSE-270 Growth Inhibition Assay IC50 = 0.7169 μM SANGER
A3-KAW Growth Inhibition Assay IC50 = 0.71692 μM SANGER
TE-12 Growth Inhibition Assay IC50 = 0.71885 μM SANGER
MDA-MB-361 Growth Inhibition Assay IC50 = 0.71909 μM SANGER
T-24 Growth Inhibition Assay IC50 = 0.71991 μM SANGER
CHL-1 Growth Inhibition Assay IC50 = 0.73154 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50 = 0.73825 μM SANGER
NCI-H1437 Growth Inhibition Assay IC50 = 0.74272 μM SANGER
Ca9-22 Growth Inhibition Assay IC50 = 0.74583 μM SANGER
EGI-1 Growth Inhibition Assay IC50 = 0.77232 μM SANGER
J82 Growth Inhibition Assay IC50 = 0.77431 μM SANGER
TE-10 Growth Inhibition Assay IC50 = 0.78312 μM SANGER
Ca-Ski Growth Inhibition Assay IC50 = 0.79823 μM SANGER
NCI-H292 Growth Inhibition Assay IC50 = 0.80316 μM SANGER
8305C Growth Inhibition Assay IC50 = 0.80431 μM SANGER
A2058 Growth Inhibition Assay IC50 = 0.80768 μM SANGER
ACN Growth Inhibition Assay IC50 = 0.80834 μM SANGER
DU-145 Growth Inhibition Assay IC50 = 0.82255 μM SANGER
SNG-M Growth Inhibition Assay IC50 = 0.83083 μM SANGER
OAW-42 Growth Inhibition Assay IC50 = 0.83182 μM SANGER
MEL-HO Growth Inhibition Assay IC50 = 0.85021 μM SANGER
ONS-76 Growth Inhibition Assay IC50 = 0.85391 μM SANGER
BV-173 Growth Inhibition Assay IC50 = 0.85487 μM SANGER
SNU-423 Growth Inhibition Assay IC50 = 0.86739 μM SANGER
MLMA Growth Inhibition Assay IC50 = 0.87048 μM SANGER
A388 Growth Inhibition Assay IC50 = 0.87718 μM SANGER
NB69 Growth Inhibition Assay IC50 = 0.92254 μM SANGER
SNU-387 Growth Inhibition Assay IC50 = 0.92472 μM SANGER
U031 Growth Inhibition Assay IC50 = 0.93436 μM SANGER
NCI-H2228 Growth Inhibition Assay IC50 = 0.95465 μM SANGER
UM-UC-3 Growth Inhibition Assay IC50 = 0.95561 μM SANGER
ALL-PO Growth Inhibition Assay IC50 = 0.98627 μM SANGER
HC-1 Growth Inhibition Assay IC50 = 0.99291 μM SANGER
SK-LU-1 Growth Inhibition Assay IC50 = 0.99868 μM SANGER
TK10 Growth Inhibition Assay IC50 = 0.99868 μM SANGER
8505C Growth Inhibition Assay IC50 = 1.03998 μM SANGER
NCCIT Growth Inhibition Assay IC50 = 1.06873 μM SANGER
NCI-H510A Growth Inhibition Assay IC50 = 1.09156 μM SANGER
NUGC-3 Growth Inhibition Assay IC50 = 1.13021 μM SANGER
DJM-1 Growth Inhibition Assay IC50 = 1.13172 μM SANGER
MCF7 Growth Inhibition Assay IC50 = 1.16584 μM SANGER
GI-1 Growth Inhibition Assay IC50 = 1.20001 μM SANGER
NCI-H747 Growth Inhibition Assay IC50 = 1.21374 μM SANGER
RPMI-7951 Growth Inhibition Assay IC50 = 1.24443 μM SANGER
RCM-1 Growth Inhibition Assay IC50 = 1.26178 μM SANGER
CHP-126 Growth Inhibition Assay IC50 = 1.26806 μM SANGER
DU-4475 Growth Inhibition Assay IC50 = 1.26828 μM SANGER
NCI-H526 Growth Inhibition Assay IC50 = 1.27996 μM SANGER
FTC-133 Growth Inhibition Assay IC50 = 1.29359 μM SANGER
NOS-1 Growth Inhibition Assay IC50 = 1.30544 μM SANGER
HuP-T4 Growth Inhibition Assay IC50 = 1.3128 μM SANGER
YT Growth Inhibition Assay IC50 = 1.31567 μM SANGER
SF268 Growth Inhibition Assay IC50 = 1.31797 μM SANGER
KYSE-70 Growth Inhibition Assay IC50 = 1.37884 μM SANGER
ES8 Growth Inhibition Assay IC50 = 1.39853 μM SANGER
MC-CAR Growth Inhibition Assay IC50 = 1.39929 μM SANGER
SW626 Growth Inhibition Assay IC50 = 1.40825 μM SANGER
BCPAP Growth Inhibition Assay IC50 = 1.43514 μM SANGER
MRK-nu-1 Growth Inhibition Assay IC50 = 1.45252 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50 = 1.45278 μM SANGER
8-MG-BA Growth Inhibition Assay IC50 = 1.47953 μM SANGER
MG-63 Growth Inhibition Assay IC50 = 1.48966 μM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50 = 1.49578 μM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50 = 1.51005 μM SANGER
697 Growth Inhibition Assay IC50 = 1.57595 μM SANGER
SW837 Growth Inhibition Assay IC50 = 1.60642 μM SANGER
ES3 Growth Inhibition Assay IC50 = 1.60859 μM SANGER
EHEB Growth Inhibition Assay IC50 = 1.60861 μM SANGER
SNB75 Growth Inhibition Assay IC50 = 1.60892 μM SANGER
Daudi Growth Inhibition Assay IC50 = 1.67096 μM SANGER
MES-SA Growth Inhibition Assay IC50 = 1.67344 μM SANGER
LK-2 Growth Inhibition Assay IC50 = 1.68921 μM SANGER
647-V Growth Inhibition Assay IC50 = 1.73341 μM SANGER
MOLT-4 Growth Inhibition Assay IC50 = 1.77334 μM SANGER
OCUB-M Growth Inhibition Assay IC50 = 1.81357 μM SANGER
EW-1 Growth Inhibition Assay IC50 = 1.81784 μM SANGER
BHY Growth Inhibition Assay IC50 = 1.82747 μM SANGER
Raji Growth Inhibition Assay IC50 = 1.84743 μM SANGER
KYSE-510 Growth Inhibition Assay IC50 = 1.85749 μM SANGER
KYSE-450 Growth Inhibition Assay IC50 = 1.93424 μM SANGER
SW962 Growth Inhibition Assay IC50 = 1.95452 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50 = 2.00542 μM SANGER
PA-1 Growth Inhibition Assay IC50 = 2.01527 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50 = 2.03812 μM SANGER
SU-DHL-1 Growth Inhibition Assay IC50 = 2.04945 μM SANGER
AU565 Growth Inhibition Assay IC50 = 2.05402 μM SANGER
MC116 Growth Inhibition Assay IC50 = 2.11053 μM SANGER
A431 Growth Inhibition Assay IC50 = 2.11197 μM SANGER
OE19 Growth Inhibition Assay IC50 = 2.14352 μM SANGER
CAL-33 Growth Inhibition Assay IC50 = 2.14602 μM SANGER
KP-4 Growth Inhibition Assay IC50 = 2.17066 μM SANGER
SJSA-1 Growth Inhibition Assay IC50 = 2.18726 μM SANGER
COLO-800 Growth Inhibition Assay IC50 = 2.20714 μM SANGER
NH-12 Growth Inhibition Assay IC50 = 2.20811 μM SANGER
IPC-298 Growth Inhibition Assay IC50 = 2.21227 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50 = 2.25537 μM SANGER
HH Growth Inhibition Assay IC50 = 2.28651 μM SANGER
BFTC-905 Growth Inhibition Assay IC50 = 2.31888 μM SANGER
RT-112 Growth Inhibition Assay IC50 = 2.31957 μM SANGER
SNU-C2B Growth Inhibition Assay IC50 = 2.32484 μM SANGER
IGR-1 Growth Inhibition Assay IC50 = 2.34633 μM SANGER
NCI-H2087 Growth Inhibition Assay IC50 = 2.34738 μM SANGER
EoL-1-cell Growth Inhibition Assay IC50 = 2.41593 μM SANGER
SCC-4 Growth Inhibition Assay IC50 = 2.4302 μM SANGER
HuH-7 Growth Inhibition Assay IC50 = 2.43456 μM SANGER
HSC-2 Growth Inhibition Assay IC50 = 2.46672 μM SANGER
NCI-H23 Growth Inhibition Assay IC50 = 2.46688 μM SANGER
AN3-CA Growth Inhibition Assay IC50 = 2.55034 μM SANGER
NCI-H2009 Growth Inhibition Assay IC50 = 2.56438 μM SANGER
NCI-H1792 Growth Inhibition Assay IC50 = 2.56683 μM SANGER
RVH-421 Growth Inhibition Assay IC50 = 2.57186 μM SANGER
SK-LMS-1 Growth Inhibition Assay IC50 = 2.65761 μM SANGER
COLO-679 Growth Inhibition Assay IC50 = 2.66172 μM SANGER
VMRC-RCZ Growth Inhibition Assay IC50 = 2.68962 μM SANGER
NCI-H28 Growth Inhibition Assay IC50 = 2.73884 μM SANGER
HT-1197 Growth Inhibition Assay IC50 = 2.74098 μM SANGER
OE33 Growth Inhibition Assay IC50 = 2.75256 μM SANGER
BT-20 Growth Inhibition Assay IC50 = 2.767 μM SANGER
NCI-H661 Growth Inhibition Assay IC50 = 2.78722 μM SANGER
HCE-T Growth Inhibition Assay IC50 = 2.83188 μM SANGER
HGC-27 Growth Inhibition Assay IC50 = 2.83636 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50 = 2.84084 μM SANGER
A253 Growth Inhibition Assay IC50 = 2.85522 μM SANGER
HCT-116 Growth Inhibition Assay IC50 = 2.88305 μM SANGER
CAPAN-1 Growth Inhibition Assay IC50 = 2.92149 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50 = 2.94674 μM SANGER
NCI-N87 Growth Inhibition Assay IC50 = 2.96422 μM SANGER
NCI-H2052 Growth Inhibition Assay IC50 = 2.96513 μM SANGER
DMS-273 Growth Inhibition Assay IC50 = 2.98076 μM SANGER
MC-IXC Growth Inhibition Assay IC50 = 2.99693 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50 = 3.02325 μM SANGER
TYK-nu Growth Inhibition Assay IC50 = 3.03067 μM SANGER
EW-7 Growth Inhibition Assay IC50 = 3.05866 μM SANGER
SK-MES-1 Growth Inhibition Assay IC50 = 3.07459 μM SANGER
SF126 Growth Inhibition Assay IC50 = 3.08914 μM SANGER
LB647-SCLC Growth Inhibition Assay IC50 = 3.14297 μM SANGER
SCC-3 Growth Inhibition Assay IC50 = 3.20606 μM SANGER
TE-15 Growth Inhibition Assay IC50 = 3.22315 μM SANGER
M14 Growth Inhibition Assay IC50 = 3.22456 μM SANGER
COLO-205 Growth Inhibition Assay IC50 = 3.24454 μM SANGER
YKG-1 Growth Inhibition Assay IC50 = 3.25583 μM SANGER
SAS Growth Inhibition Assay IC50 = 3.26145 μM SANGER
G-401 Growth Inhibition Assay IC50 = 3.2899 μM SANGER
CAL-62 Growth Inhibition Assay IC50 = 3.34045 μM SANGER
HCC1599 Growth Inhibition Assay IC50 = 3.36875 μM SANGER
JiyoyeP-2003 Growth Inhibition Assay IC50 = 3.38494 μM SANGER
IA-LM Growth Inhibition Assay IC50 = 3.4017 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50 = 3.43354 μM SANGER
SW872 Growth Inhibition Assay IC50 = 3.45241 μM SANGER
SW620 Growth Inhibition Assay IC50 = 3.55738 μM SANGER
M059J Growth Inhibition Assay IC50 = 3.76703 μM SANGER
KYSE-180 Growth Inhibition Assay IC50 = 3.79836 μM SANGER
BxPC-3 Growth Inhibition Assay IC50 = 3.80576 μM SANGER
D-283MED Growth Inhibition Assay IC50 = 3.81218 μM SANGER
KYSE-140 Growth Inhibition Assay IC50 = 3.89603 μM SANGER
BC-1 Growth Inhibition Assay IC50 = 3.91812 μM SANGER
HLE Growth Inhibition Assay IC50 = 3.99693 μM SANGER
MN-60 Growth Inhibition Assay IC50 = 4.05162 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50 = 4.1047 μM SANGER
IM-9 Growth Inhibition Assay IC50 = 4.13195 μM SANGER
NOMO-1 Growth Inhibition Assay IC50 = 4.20151 μM SANGER
SW1990 Growth Inhibition Assay IC50 = 4.24402 μM SANGER
NCI-H2405 Growth Inhibition Assay IC50 = 4.27798 μM SANGER
LAMA-84 Growth Inhibition Assay IC50 = 4.28656 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50 = 4.30277 μM SANGER
EFO-21 Growth Inhibition Assay IC50 = 4.33027 μM SANGER
U251 Growth Inhibition Assay IC50 = 4.36314 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50 = 4.41035 μM SANGER
HO-1-N-1 Growth Inhibition Assay IC50 = 4.41781 μM SANGER
CaR-1 Growth Inhibition Assay IC50 = 4.44726 μM SANGER
CCF-STTG1 Growth Inhibition Assay IC50 = 4.56209 μM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50 = 4.59384 μM SANGER
CAL-148 Growth Inhibition Assay IC50 = 4.60119 μM SANGER
OVCAR-5 Growth Inhibition Assay IC50 = 4.74899 μM SANGER
NCI-H460 Growth Inhibition Assay IC50 = 4.75506 μM SANGER
HuP-T3 Growth Inhibition Assay IC50 = 4.79184 μM SANGER
SK-OV-3 Growth Inhibition Assay IC50 = 4.88426 μM SANGER
VM-CUB-1 Growth Inhibition Assay IC50 = 4.91668 μM SANGER
CTV-1 Growth Inhibition Assay IC50 = 4.92002 μM SANGER
AM-38 Growth Inhibition Assay IC50 = 4.94112 μM SANGER
GCT Growth Inhibition Assay IC50 = 4.99065 μM SANGER
NCI-H2347 Growth Inhibition Assay IC50 = 5.11661 μM SANGER
DB Growth Inhibition Assay IC50 = 5.11905 μM SANGER
FADU Growth Inhibition Assay IC50 = 5.13773 μM SANGER
Calu-1 Growth Inhibition Assay IC50 = 5.13779 μM SANGER
NCI-H2030 Growth Inhibition Assay IC50 = 5.21763 μM SANGER
DOHH-2 Growth Inhibition Assay IC50 = 5.28851 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50 = 5.29092 μM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50 = 5.54575 μM SANGER
HT Growth Inhibition Assay IC50 = 5.55505 μM SANGER
CAL-120 Growth Inhibition Assay IC50 = 5.56142 μM SANGER
DBTRG-05MG Growth Inhibition Assay IC50 = 5.67305 μM SANGER
COLO-680N Growth Inhibition Assay IC50 = 5.7583 μM SANGER
HT-3 Growth Inhibition Assay IC50 = 5.77714 μM SANGER
NY Growth Inhibition Assay IC50 = 5.91176 μM SANGER
NCI-H838 Growth Inhibition Assay IC50 = 5.94757 μM SANGER
NCI-H1618 Growth Inhibition Assay IC50 = 5.98557 μM SANGER
TE-11 Growth Inhibition Assay IC50 = 6.08459 μM SANGER
Calu-3 Growth Inhibition Assay IC50 = 6.19074 μM SANGER
ST486 Growth Inhibition Assay IC50 = 6.39405 μM SANGER
EW-11 Growth Inhibition Assay IC50 = 6.41293 μM SANGER
TE-1 Growth Inhibition Assay IC50 = 6.42507 μM SANGER
NB5 Growth Inhibition Assay IC50 = 6.72078 μM SANGER
DMS-114 Growth Inhibition Assay IC50 = 6.78617 μM SANGER
KYSE-520 Growth Inhibition Assay IC50 = 6.78887 μM SANGER
SIMA Growth Inhibition Assay IC50 = 6.93011 μM SANGER
KM-H2 Growth Inhibition Assay IC50 = 6.96614 μM SANGER
WM-115 Growth Inhibition Assay IC50 = 7.09344 μM SANGER
P30-OHK Growth Inhibition Assay IC50 = 7.09585 μM SANGER
22RV1 Growth Inhibition Assay IC50 = 7.32932 μM SANGER
BHT-101 Growth Inhibition Assay IC50 = 7.34054 μM SANGER
COR-L105 Growth Inhibition Assay IC50 = 7.36534 μM SANGER
Calu-6 Growth Inhibition Assay IC50 = 7.67159 μM SANGER
C8166 Growth Inhibition Assay IC50 = 7.77036 μM SANGER
SH-4 Growth Inhibition Assay IC50 = 7.84755 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50 = 7.9095 μM SANGER
TE-5 Growth Inhibition Assay IC50 = 7.96408 μM SANGER
CAL-27 Growth Inhibition Assay IC50 = 8.07296 μM SANGER
KYSE-410 Growth Inhibition Assay IC50 = 8.1465 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50 = 8.20414 μM SANGER
LB831-BLC Growth Inhibition Assay IC50 = 8.38272 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50 = 8.48548 μM SANGER
JEG-3 Growth Inhibition Assay IC50 = 8.5506 μM SANGER
NCI-H441 Growth Inhibition Assay IC50 = 9.04985 μM SANGER
KM12 Growth Inhibition Assay IC50 = 9.18802 μM SANGER
OAW-28 Growth Inhibition Assay IC50 = 9.20646 μM SANGER
HOP-92 Growth Inhibition Assay IC50 = 9.26 μM SANGER
HT-1376 Growth Inhibition Assay IC50 = 9.73755 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50 = 9.88105 μM SANGER
NCI-H727 Growth Inhibition Assay IC50 = 10.3102 μM SANGER
A673 Growth Inhibition Assay IC50 = 10.4566 μM SANGER
A704 Growth Inhibition Assay IC50 = 10.6436 μM SANGER
HEL Growth Inhibition Assay IC50 = 10.8362 μM SANGER
HuCCT1 Growth Inhibition Assay IC50 = 10.9343 μM SANGER
U-87-MG Growth Inhibition Assay IC50 = 11.0572 μM SANGER
LC4-1 Growth Inhibition Assay IC50 = 11.1604 μM SANGER
SW756 Growth Inhibition Assay IC50 = 11.3757 μM SANGER
NCI-H1882 Growth Inhibition Assay IC50 = 11.455 μM SANGER
NB1 Growth Inhibition Assay IC50 = 11.5965 μM SANGER
KALS-1 Growth Inhibition Assay IC50 = 11.7421 μM SANGER
OMC-1 Growth Inhibition Assay IC50 = 11.8941 μM SANGER
Detroit562 Growth Inhibition Assay IC50 = 11.931 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50 = 12.0521 μM SANGER
TE-6 Growth Inhibition Assay IC50 = 12.3857 μM SANGER
GCIY Growth Inhibition Assay IC50 = 12.7546 μM SANGER
U-698-M Growth Inhibition Assay IC50 = 13.0065 μM SANGER
PC-3 Growth Inhibition Assay IC50 = 13.3146 μM SANGER
T84 Growth Inhibition Assay IC50 = 13.4592 μM SANGER
NCI-H596 Growth Inhibition Assay IC50 = 13.5755 μM SANGER
D-392MG Growth Inhibition Assay IC50 = 13.5799 μM SANGER
NB10 Growth Inhibition Assay IC50 = 13.8464 μM SANGER
BL-41 Growth Inhibition Assay IC50 = 14.1975 μM SANGER
HDLM-2 Growth Inhibition Assay IC50 = 14.3177 μM SANGER
LAN-6 Growth Inhibition Assay IC50 = 14.6341 μM SANGER
CMK Growth Inhibition Assay IC50 = 14.7963 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50 = 15.4155 μM SANGER
GP5d Growth Inhibition Assay IC50 = 15.636 μM SANGER
TCCSUP Growth Inhibition Assay IC50 = 15.9419 μM SANGER
NCI-H520 Growth Inhibition Assay IC50 = 16.0521 μM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50 = 16.3642 μM SANGER
COLO-741 Growth Inhibition Assay IC50 = 16.4227 μM SANGER
NCI-H1693 Growth Inhibition Assay IC50 = 16.565 μM SANGER
DG-75 Growth Inhibition Assay IC50 = 16.9142 μM SANGER
CAMA-1 Growth Inhibition Assay IC50 = 17.5247 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50 = 18.3155 μM SANGER
EW-3 Growth Inhibition Assay IC50 = 18.5014 μM SANGER
TUR Growth Inhibition Assay IC50 = 18.8518 μM SANGER
NCI-H446 Growth Inhibition Assay IC50 = 18.8813 μM SANGER
ATN-1 Growth Inhibition Assay IC50 = 18.9202 μM SANGER
LU-65 Growth Inhibition Assay IC50 = 19.4673 μM SANGER
ABC-1 Growth Inhibition Assay IC50 = 19.6679 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50 = 20.3205 μM SANGER
Caov-3 Growth Inhibition Assay IC50 = 20.4613 μM SANGER
NCI-H1563 Growth Inhibition Assay IC50 = 20.6061 μM SANGER
KLE Growth Inhibition Assay IC50 = 21.24 μM SANGER
MMAC-SF Growth Inhibition Assay IC50 = 21.327 μM SANGER
BB65-RCC Growth Inhibition Assay IC50 = 21.4262 μM SANGER
EB-3 Growth Inhibition Assay IC50 = 21.8331 μM SANGER
SK-MEL-3 Growth Inhibition Assay IC50 = 22.1755 μM SANGER
NCI-H2196 Growth Inhibition Assay IC50 = 22.8494 μM SANGER
GR-ST Growth Inhibition Assay IC50 = 23.0977 μM SANGER
SK-MM-2 Growth Inhibition Assay IC50 = 23.239 μM SANGER
SK-MEL-24 Growth Inhibition Assay IC50 = 23.2952 μM SANGER
LS-123 Growth Inhibition Assay IC50 = 23.4283 μM SANGER
SW1463 Growth Inhibition Assay IC50 = 23.4421 μM SANGER
L-540 Growth Inhibition Assay IC50 = 23.5493 μM SANGER
Capan-2 Growth Inhibition Assay IC50 = 24.2155 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50 = 24.5232 μM SANGER
TE-441-T Growth Inhibition Assay IC50 = 24.6153 μM SANGER
A4-Fuk Growth Inhibition Assay IC50 = 25.288 μM SANGER
COR-L279 Growth Inhibition Assay IC50 = 25.3526 μM SANGER
KE-37 Growth Inhibition Assay IC50 = 25.9179 μM SANGER
NCI-H1755 Growth Inhibition Assay IC50 = 26.001 μM SANGER
KP-N-YN Growth Inhibition Assay IC50 = 26.337 μM SANGER
COLO-792 Growth Inhibition Assay IC50 = 26.4052 μM SANGER
Becker Growth Inhibition Assay IC50 = 26.9253 μM SANGER
no-10 Growth Inhibition Assay IC50 = 27.0943 μM SANGER
NCI-H1793 Growth Inhibition Assay IC50 = 27.172 μM SANGER
HCC1143 Growth Inhibition Assay IC50 = 27.1918 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50 = 27.2024 μM SANGER
HEC-1 Growth Inhibition Assay IC50 = 27.3627 μM SANGER
SCC-15 Growth Inhibition Assay IC50 = 27.6315 μM SANGER
LS-513 Growth Inhibition Assay IC50 = 28.9662 μM SANGER
HN Growth Inhibition Assay IC50 = 29.1374 μM SANGER
MOLT-16 Growth Inhibition Assay IC50 = 29.5165 μM SANGER
KP-N-YS Growth Inhibition Assay IC50 = 30.2856 μM SANGER
NCI-H1417 Growth Inhibition Assay IC50 = 30.3916 μM SANGER
RPMI-8402 Growth Inhibition Assay IC50 = 30.7398 μM SANGER
WSU-NHL Growth Inhibition Assay IC50 = 31.634 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50 = 31.88 μM SANGER
HCC1187 Growth Inhibition Assay IC50 = 32.9082 μM SANGER
PFSK-1 Growth Inhibition Assay IC50 = 33.4435 μM SANGER
TE-9 Growth Inhibition Assay IC50 = 33.9766 μM SANGER
NCI-H209 Growth Inhibition Assay IC50 = 34.3161 μM SANGER
HL-60 Growth Inhibition Assay IC50 = 35.2849 μM SANGER
LS-1034 Growth Inhibition Assay IC50 = 35.3757 μM SANGER
NCI-H2141 Growth Inhibition Assay IC50 = 36.1155 μM SANGER
COLO-678 Growth Inhibition Assay IC50 = 36.2389 μM SANGER
NB13 Growth Inhibition Assay IC50 = 36.744 μM SANGER
COLO-829 Growth Inhibition Assay IC50 = 36.9718 μM SANGER
BB49-HNC Growth Inhibition Assay IC50 = 38.7612 μM SANGER
NCI-H1623 Growth Inhibition Assay IC50 = 39.0477 μM SANGER
A172 Growth Inhibition Assay IC50 = 39.7268 μM SANGER
MPP-89 Growth Inhibition Assay IC50 = 39.8805 μM SANGER
ME-180 Growth Inhibition Assay IC50 = 40.8628 μM SANGER
LU-165 Growth Inhibition Assay IC50 = 41.7959 μM SANGER
LU-134-A Growth Inhibition Assay IC50 = 41.8216 μM SANGER
HCC2218 Growth Inhibition Assay IC50 = 41.8898 μM SANGER
NCI-H1694 Growth Inhibition Assay IC50 = 43.8822 μM SANGER
BEN Growth Inhibition Assay IC50 = 46.0431 μM SANGER
RERF-LC-MS Growth Inhibition Assay IC50 = 48.6853 μM SANGER
LC-1F Growth Inhibition Assay IC50 = 49.4076 μM SANGER
L-428 Growth Inhibition Assay IC50 = 52.3358 μM SANGER
CPC-N Growth Inhibition Assay IC50 = 52.489 μM SANGER
COLO-824 Growth Inhibition Assay IC50 = 53.329 μM SANGER
IST-SL1 Growth Inhibition Assay IC50 = 54.5851 μM SANGER
NCI-H810 Growth Inhibition Assay IC50 = 55.1277 μM SANGER
LB373-MEL-D Growth Inhibition Assay IC50 = 56.4075 μM SANGER
ECC4 Growth Inhibition Assay IC50 = 56.7007 μM SANGER
TT Growth Inhibition Assay IC50 = 59.1501 μM SANGER
D-542MG Growth Inhibition Assay IC50 = 60.2794 μM SANGER
T98G Growth Inhibition Assay IC50 = 63.7348 μM SANGER
U-118-MG Growth Inhibition Assay IC50 = 65.6647 μM SANGER
TGW Growth Inhibition Assay IC50 = 65.7504 μM SANGER
MKN7 Growth Inhibition Assay IC50 = 66.5296 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50 = 67.3338 μM SANGER
SNU-475 Growth Inhibition Assay IC50 = 67.5008 μM SANGER
MDA-MB-468 Growth Inhibition Assay IC50 = 67.5522 μM SANGER
KU812 Growth Inhibition Assay IC50 = 67.9601 μM SANGER
RCC10RGB Growth Inhibition Assay IC50 = 70.5644 μM SANGER
K5 Growth Inhibition Assay IC50 = 72.3646 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50 = 73.2129 μM SANGER
COR-L88 Growth Inhibition Assay IC50 = 73.4243 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50 = 74.14 μM SANGER
NCI-H748 Growth Inhibition Assay IC50 = 75.1768 μM SANGER
EW-18 Growth Inhibition Assay IC50 = 75.8498 μM SANGER
NCI-H226 Growth Inhibition Assay IC50 = 77.3602 μM SANGER
HTC-C3 Growth Inhibition Assay IC50 = 77.8428 μM SANGER
CAS-1 Growth Inhibition Assay IC50 = 81.0296 μM SANGER
SNU-C1 Growth Inhibition Assay IC50 = 81.9941 μM SANGER
NB12 Growth Inhibition Assay IC50 = 82.3997 μM SANGER
AsPC-1 Growth Inhibition Assay IC50 = 82.5028 μM SANGER
HCC1954 Growth Inhibition Assay IC50 = 84.163 μM SANGER
EM-2 Growth Inhibition Assay IC50 = 84.7528 μM SANGER
CA46 Growth Inhibition Assay IC50 = 84.8498 μM SANGER
no-11 Growth Inhibition Assay IC50 = 85.5708 μM SANGER
DK-MG Growth Inhibition Assay IC50 = 85.7672 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50 = 87.8298 μM SANGER
S-117 Growth Inhibition Assay IC50 = 90.2444 μM SANGER
C2BBe1 Growth Inhibition Assay IC50 = 91.8016 μM SANGER
THP-1 Growth Inhibition Assay IC50 = 92.4868 μM SANGER
HCC2157 Growth Inhibition Assay IC50 = 93.3592 μM SANGER
EW-24 Growth Inhibition Assay IC50 = 95.3316 μM SANGER
UACC-812 Growth Inhibition Assay IC50 = 99.5951 μM SANGER
NCI-H720 Growth Inhibition Assay IC50 = 103.351 μM SANGER
NCI-H69 Growth Inhibition Assay IC50 = 103.909 μM SANGER
OPM-2 Growth Inhibition Assay IC50 = 104.066 μM SANGER
RD Growth Inhibition Assay IC50 = 105.698 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50 = 110.224 μM SANGER
OVCAR-3 Growth Inhibition Assay IC50 = 123.332 μM SANGER
HCC70 Growth Inhibition Assay IC50 = 125.868 μM SANGER
GAK Growth Inhibition Assay IC50 = 126.132 μM SANGER
K-562 Growth Inhibition Assay IC50 = 126.227 μM SANGER
UACC-893 Growth Inhibition Assay IC50 = 129.777 μM SANGER
SKG-IIIa Growth Inhibition Assay IC50 = 136.469 μM SANGER
SHP-77 Growth Inhibition Assay IC50 = 142.135 μM SANGER
D-263MG Growth Inhibition Assay IC50 = 142.206 μM SANGER
Mewo Growth Inhibition Assay IC50 = 147.962 μM SANGER
MSTO-211H Growth Inhibition Assay IC50 = 149.459 μM SANGER
Click to View More Cell Line Experimental Data

Biological Activity

Description Bleomycin sulfate is a glycopeptide antibiotic and a DNA synthesis inhibitor, as well as an anticancer agent for squamous cell carcinomas (SCC) with an IC50 of 4 nM in UT-SCC-19A cells. Bleomycin sulfate is a DNA synthesis inhibitor.
In vitro
In vitro

UT-SCC-12A and UT-SCC-12B are both more resistant to Bleomycin sulfate with IC50 of 14.2 nM and 13 nM, respectively. [1] Alveolar macrophages incubated with 0.01 μg/mL to 1μg /mL Bleomycin sulfate for 18 hours secretes significantly more fibroblast growth factor than macrophages incubated without Bleomycin sulfate. Macrophages stimulated with Bleomycin sulfate continues to produce significant amounts of fibroblast growth factor even after Bleomycin sulfate is removed and replaced with fresh (Bleomycin sulfate-free) media. Fibroblast growth factor secretion by Bleomycin sulfate-stimulated alveolar macrophages is inhibited by cycloheximide, and the 5-lipoxygenase inhibitors NDGA (nordihydroguaiaretic acid) and BW755c, indicating not only a requirement for protein synthesis but also for metabolites of the 5-lipoxygenase pathway of arachidonic acid metabolism for full expression of activity. [2] Bleomycin sulfate (400 µg/mL) incubation for 24 hours decreases the viability of NTera-2 cells, and increases caspase-3, -8 and -9 activities, Bax and cytoplasmic cytochrome c levels and decreases Bcl-2 levels. [3] In terms of unstable aberrations, the clastogenic effect of Bleomycin sulfate on ADIPO-P2 cells persists for at least 10 days after exposure. Bleomycin sulfate-induced telomere instability in mammalian cells persists for several generations after exposure. Moreover, the appearance of telomere fusions in Bleomycin sulfate-exposed cells 10 days after treatment suggests that Bleomycin sulfate can induce delayed telomere instability. [4]
Cell Research Cell lines ADIPO-P2 cells
Concentrations 2.5 μg/mL
Incubation Time 30 minutes
Method

ADIPO-P2 cells are grown in D-MEM high glucose medium supplemented with 20% fetal calf serum, penicillin (100 U/mL) and streptomycin (100 μg/mL) at 37 °C and 5% CO2 atmosphere. Cells are cultured as monolayer in TC25 Corning flasks containing 1.5 × 105 cells/mL. For each experiment, two flasks are set up, one for the control and one for the treated culture. During the log phase of growth ADIPO-P2 cells are treated with a 30 minutes pulse of 2.5 μg/mL of Bleomycin sulfate. Control cultures are set up in parallel but not exposed to Bleomycin sulfate. Time of exposure and concentration of Bleomycin sulfate are chosen according to previous studies carried out in our laboratory with mammalian cells exposed to Bleomycin sulfate. At the end of the pulse treatment with Bleomycin sulfate, the cells are washed twice with Hank's balanced salt solution and kept in culture with fresh culture medium until harvesting. Cells are continuously maintained in culture during 5 passages or subcultures after treatment. Subcultivation is carried out whenever the cultures became confluent (approximately 4 × 105 cells/mL of culture medium). To estimate cell growth, at the time of subcultivation cells are collected by trypsinization, an aliquot of about 200 μL stained with 0.4% trypan blue, and the number of viable cells is determined. Cells are then suspended in fresh culture medium and dispensed into new culture flasks containing 1 × 105 cells/mL to continue growing. The rest of the cells is discarded or dispensed in another flask for cytogenetic analysis, which is performed at 18 hours and 10 days after the end of treatments. To analyze chromosomal aberrations, colchicine (0.1 μg/mL) is added to cell cultures during the last 3 hours of culture. Chromosome preparations are made following standard procedures. After harvesting, cells are hypotonically shocked, fixed in methanol:acetic acid (3:1), spread onto glass slides and processed for PNA-FISH. Two independent experiments are carried out.
Experimental Result Images Methods Biomarkers Images PMID
Western blot LRP6 / Wnt5AB / Dvl2 / β-catenin phospho-eIF2α / eIF2α cytochrome c Bcl-xl Bcl-2 27649046
Immunofluorescence LC3 23762310
ELISA HMGB1 23762310
In Vivo
In vivo

Day 7 post-Bleomycin sulfate, CD45+ cells in BALf in NOX-/- is 1.7-fold > WT, 57% of which are Mf that decreases by 67% in WT and 83% in NOX-/- by Day 21. [5]
Animal Research Animal Models CD-1 mice
Dosages 5 mg/kg, 2 ml/kg
Administration Administered via i.t.

Chemical lnformation & Solubility

Molecular Weight 1512.62 Formula

C55H85N17O25S4
CAS No. 9041-93-4 SDF Download Bleomycin sulfate SDF
Smiles CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (66.11 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
what is the ratio between bleomycin A2 and bleomycin B2 in your product?

Answer:
The content of Bleomycin A2 and Bleomycin B2 is 62% and 29% respectively.

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