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Budesonide

Name: Budesonide
Brand: Selleck Chemicals
SKU: S1286
Rating: 5 (5 reviews)

Synonyms: Labazenit

Catalog No.S1286 Purity: 99.97%

Budesonide(Labazenit) is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.

Budesonide Chemical Structure

CAS: 51333-22-3

Selleck's Budesonide has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.97%

99.97

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Biological Activity

Description

Budesonide(Labazenit) is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.

Targets

Glucocorticoid receptor ^[1]

In vitro
In vitro	Budesonide effectively inhibits production of eotaxin and RANTES protein although Budesonide inhibits the expression of chemokine mRNA to a variable extent in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. Budesonide inhibits both RANTES- and eotaxin promoter-driven reporter gene activity in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. Budesonide also selectively accelerates the decay of eotaxin and MCP-4 mRNA in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. ^[1] Budesonide time- and protein synthesis-dependently reduces VEGF secretion and VEGF mRNA expression in both cell types and these effects are inhibited by mifepristone (RU 486), a glucocorticoid receptor antagonist, suggesting that Budesonide reduces VEGF secretion and expression through its glucocorticoid receptor-mediated action. ^[2] Budesonide causes a dose-dependent, almost total, inhibition of swine dust-induced IL-6 and IL-8 release from epithelial cells and LPS-induced IL-6 and TNF-alpha from alveolar macrophages. ^[3]

In Vivo
In vivo	Budesonide totally prevents the increased production of TNF-alpha, interleukin (IL)-1beta, IL-6, and monocyte chemoattractive protein (MCP)-1 after LPS challenge at both low (2.5 mg/mL/kg) and high (50 mg/mL/kg) concentrations in rats. ^[4] Budesonide exerts its effects of chemoprevention through growth arrest via Mad2/3 and through apoptosis via Bim/Blk and, by inference, caspase-8/9 in A/J mice. ^[5]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05341401	Not yet recruiting	Ulcerative Colitis Chronic	Assiut University	June 2022	Phase 2\|Phase 3
NCT05148312	Completed	Pharmacokinetics	Aquilon Pharmaceuticals S.A.	November 12 2021	Phase 1
NCT04342039	Active not recruiting	Epigenetic Effects of Intranasal Steroids\|Environmental Exposure	University of British Columbia\|Genome British Columbia\|Johnson & Johnson Consumer Inc. (J&JCI)	January 7 2021	Phase 4
NCT04663386	Terminated	Asthma\|COPD	Orion Corporation Orion Pharma	December 10 2020	--

References

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Chemical lnformation & Solubility

Molecular Weight	430.53	Formula	C₂₅H₃₄O₆
CAS No.	51333-22-3	SDF	Download Budesonide SDF
Smiles	CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 86 mg/mL ( (199.75 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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