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Docetaxel
Synonyms: NSC 628503,RP56976
Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Docetaxel Chemical Structure
CAS: 114977-28-5
Selleck's Docetaxel has been cited by 193 publications
Purity & Quality Control
Batch:
Purity:
99.98%
99.98
Other Microtubule Associated Products
Related compound libraries
Choose Selective Microtubule Associated Inhibitors
Cell Data
| Cell Lines | Assay Type | Concentration | Incubation Time | Formulation | Activity Description | PMID |
|---|---|---|---|---|---|---|
| HSC-3 | Growth Inhibition Assay | IC50=0.000132 μM | SANGER | |||
| 5637 | Growth Inhibition Assay | IC50=0.000143 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=0.000157 μM | SANGER | |||
| NCI-H292 | Growth Inhibition Assay | IC50=0.000159 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=0.000162 μM | SANGER | |||
| ESS-1 | Growth Inhibition Assay | IC50=0.000179 μM | SANGER | |||
| D-566MG | Growth Inhibition Assay | IC50=0.000182 μM | SANGER | |||
| CAL-62 | Growth Inhibition Assay | IC50=0.000185 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=0.000232 μM | SANGER | |||
| HSC-4 | Growth Inhibition Assay | IC50=0.000239 μM | SANGER | |||
| KOSC-2 | Growth Inhibition Assay | IC50=0.000255 μM | SANGER | |||
| NB14 | Growth Inhibition Assay | IC50=0.00026 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=0.00026 μM | SANGER | |||
| BFTC-905 | Growth Inhibition Assay | IC50=0.000268 μM | SANGER | |||
| A498 | Growth Inhibition Assay | IC50=0.000278 μM | SANGER | |||
| HO-1-N-1 | Growth Inhibition Assay | IC50=0.000281 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=0.000302 μM | SANGER | |||
| HuO-3N1 | Growth Inhibition Assay | IC50=0.000302 μM | SANGER | |||
| NCI-H510A | Growth Inhibition Assay | IC50=0.000336 μM | SANGER | |||
| CAL-27 | Growth Inhibition Assay | IC50=0.000339 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=0.000366 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.000375 μM | SANGER | |||
| RH-1 | Growth Inhibition Assay | IC50=0.000386 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=0.000388 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=0.000389 μM | SANGER | |||
| GAMG | Growth Inhibition Assay | IC50=0.000416 μM | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | IC50=0.000423 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=0.00043 μM | SANGER | |||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.000448 μM | SANGER | |||
| SW1710 | Growth Inhibition Assay | IC50=0.000466 μM | SANGER | |||
| HGC-27 | Growth Inhibition Assay | IC50=0.000471 μM | SANGER | |||
| MC-IXC | Growth Inhibition Assay | IC50=0.000479 μM | SANGER | |||
| FTC-133 | Growth Inhibition Assay | IC50=0.000489 μM | SANGER | |||
| HT-1080 | Growth Inhibition Assay | IC50=0.000501 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=0.000517 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=0.000528 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.000542 μM | SANGER | |||
| A2058 | Growth Inhibition Assay | IC50=0.000544 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=0.000558 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=0.000561 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=0.000569 μM | SANGER | |||
| NCI-H720 | Growth Inhibition Assay | IC50=0.00058 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=0.000581 μM | SANGER | |||
| SW780 | Growth Inhibition Assay | IC50=0.000587 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.000589 μM | SANGER | |||
| EC-GI-10 | Growth Inhibition Assay | IC50=0.000592 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=0.000615 μM | SANGER | |||
| 639-V | Growth Inhibition Assay | IC50=0.000647 μM | SANGER | |||
| PFSK-1 | Growth Inhibition Assay | IC50=0.000657 μM | SANGER | |||
| DMS-273 | Growth Inhibition Assay | IC50=0.000674 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=0.000676 μM | SANGER | |||
| SCC-25 | Growth Inhibition Assay | IC50=0.00068 μM | SANGER | |||
| PA-1 | Growth Inhibition Assay | IC50=0.000687 μM | SANGER | |||
| MHH-ES-1 | Growth Inhibition Assay | IC50=0.0007 μM | SANGER | |||
| Daoy | Growth Inhibition Assay | IC50=0.0007 μM | SANGER | |||
| G-402 | Growth Inhibition Assay | IC50=0.000706 μM | SANGER | |||
| YKG-1 | Growth Inhibition Assay | IC50=0.000707 μM | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | IC50=0.000728 μM | SANGER | |||
| CHP-212 | Growth Inhibition Assay | IC50=0.00073 μM | SANGER | |||
| SCC-4 | Growth Inhibition Assay | IC50=0.000739 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=0.000745 μM | SANGER | |||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=0.000745 μM | SANGER | |||
| HSC-2 | Growth Inhibition Assay | IC50=0.000755 μM | SANGER | |||
| HN | Growth Inhibition Assay | IC50=0.000758 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=0.000758 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=0.00077 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.000773 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=0.000778 μM | SANGER | |||
| HOS | Growth Inhibition Assay | IC50=0.000782 μM | SANGER | |||
| YH-13 | Growth Inhibition Assay | IC50=0.000791 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=0.000823 μM | SANGER | |||
| KYSE-510 | Growth Inhibition Assay | IC50=0.00084 μM | SANGER | |||
| 8505C | Growth Inhibition Assay | IC50=0.000854 μM | SANGER | |||
| A549 | Growth Inhibition Assay | IC50=0.000882 μM | SANGER | |||
| Detroit562 | Growth Inhibition Assay | IC50=0.000902 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=0.00091 μM | SANGER | |||
| KYSE-140 | Growth Inhibition Assay | IC50=0.000933 μM | SANGER | |||
| GMS-10 | Growth Inhibition Assay | IC50=0.000941 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=0.000947 μM | SANGER | |||
| BCPAP | Growth Inhibition Assay | IC50=0.000947 μM | SANGER | |||
| CHL-1 | Growth Inhibition Assay | IC50=0.000958 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=0.000989 μM | SANGER | |||
| SW48 | Growth Inhibition Assay | IC50=0.00101 μM | SANGER | |||
| BPH-1 | Growth Inhibition Assay | IC50=0.00102 μM | SANGER | |||
| EFO-27 | Growth Inhibition Assay | IC50=0.00102 μM | SANGER | |||
| CAL-33 | Growth Inhibition Assay | IC50=0.00104 μM | SANGER | |||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.00104 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=0.00105 μM | SANGER | |||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.00105 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=0.00106 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=0.00107 μM | SANGER | |||
| NBsusSR | Growth Inhibition Assay | IC50=0.0011 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=0.0011 μM | SANGER | |||
| EPLC-272H | Growth Inhibition Assay | IC50=0.00111 μM | SANGER | |||
| KNS-62 | Growth Inhibition Assay | IC50=0.00112 μM | SANGER | |||
| RERF-LC-MS | Growth Inhibition Assay | IC50=0.00113 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=0.00116 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=0.00117 μM | SANGER | |||
| T98G | Growth Inhibition Assay | IC50=0.00117 μM | SANGER | |||
| HCC1806 | Growth Inhibition Assay | IC50=0.00118 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=0.00118 μM | SANGER | |||
| RT-112 | Growth Inhibition Assay | IC50=0.00119 μM | SANGER | |||
| LK-2 | Growth Inhibition Assay | IC50=0.00121 μM | SANGER | |||
| A375 | Growth Inhibition Assay | IC50=0.00121 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=0.00121 μM | SANGER | |||
| H9 | Growth Inhibition Assay | IC50=0.00124 μM | SANGER | |||
| KYSE-410 | Growth Inhibition Assay | IC50=0.00124 μM | SANGER | |||
| G-401 | Growth Inhibition Assay | IC50=0.00127 μM | SANGER | |||
| SW982 | Growth Inhibition Assay | IC50=0.00127 μM | SANGER | |||
| D-423MG | Growth Inhibition Assay | IC50=0.0013 μM | SANGER | |||
| CAMA-1 | Growth Inhibition Assay | IC50=0.00131 μM | SANGER | |||
| SCC-9 | Growth Inhibition Assay | IC50=0.00132 μM | SANGER | |||
| SAS | Growth Inhibition Assay | IC50=0.00134 μM | SANGER | |||
| KYSE-180 | Growth Inhibition Assay | IC50=0.00135 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=0.00135 μM | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.00141 μM | SANGER | |||
| KYSE-450 | Growth Inhibition Assay | IC50=0.00143 μM | SANGER | |||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.00144 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=0.00144 μM | SANGER | |||
| TI-73 | Growth Inhibition Assay | IC50=0.00144 μM | SANGER | |||
| A427 | Growth Inhibition Assay | IC50=0.00148 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=0.00148 μM | SANGER | |||
| MG-63 | Growth Inhibition Assay | IC50=0.00151 μM | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.00154 μM | SANGER | |||
| 23132-87 | Growth Inhibition Assay | IC50=0.00155 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=0.00155 μM | SANGER | |||
| KP-4 | Growth Inhibition Assay | IC50=0.00156 μM | SANGER | |||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.00157 μM | SANGER | |||
| MCF7 | Growth Inhibition Assay | IC50=0.00161 μM | SANGER | |||
| A172 | Growth Inhibition Assay | IC50=0.00163 μM | SANGER | |||
| CAL-39 | Growth Inhibition Assay | IC50=0.00163 μM | SANGER | |||
| Saos-2 | Growth Inhibition Assay | IC50=0.00168 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=0.00169 μM | SANGER | |||
| D-336MG | Growth Inhibition Assay | IC50=0.00169 μM | SANGER | |||
| SW13 | Growth Inhibition Assay | IC50=0.00169 μM | SANGER | |||
| ME-180 | Growth Inhibition Assay | IC50=0.00169 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.0017 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=0.00172 μM | SANGER | |||
| D-247MG | Growth Inhibition Assay | IC50=0.00173 μM | SANGER | |||
| EoL-1-cell | Growth Inhibition Assay | IC50=0.00173 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=0.00174 μM | SANGER | |||
| U-2-OS | Growth Inhibition Assay | IC50=0.00175 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=0.00176 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=0.00176 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=0.00178 μM | SANGER | |||
| GCT | Growth Inhibition Assay | IC50=0.0018 μM | SANGER | |||
| HCT-116 | Growth Inhibition Assay | IC50=0.00181 μM | SANGER | |||
| AU565 | Growth Inhibition Assay | IC50=0.00181 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=0.00181 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=0.00182 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=0.00183 μM | SANGER | |||
| 647-V | Growth Inhibition Assay | IC50=0.00184 μM | SANGER | |||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.00184 μM | SANGER | |||
| SBC-5 | Growth Inhibition Assay | IC50=0.00187 μM | SANGER | |||
| NB17 | Growth Inhibition Assay | IC50=0.00189 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=0.00189 μM | SANGER | |||
| M14 | Growth Inhibition Assay | IC50=0.00191 μM | SANGER | |||
| NCI-H1048 | Growth Inhibition Assay | IC50=0.00192 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=0.00192 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.00194 μM | SANGER | |||
| H4 | Growth Inhibition Assay | IC50=0.00196 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.00197 μM | SANGER | |||
| M059J | Growth Inhibition Assay | IC50=0.00198 μM | SANGER | |||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.00199 μM | SANGER | |||
| SK-MEL-28 | Growth Inhibition Assay | IC50=0.00203 μM | SANGER | |||
| PC-14 | Growth Inhibition Assay | IC50=0.00209 μM | SANGER | |||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.00212 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=0.00212 μM | SANGER | |||
| EFM-19 | Growth Inhibition Assay | IC50=0.00215 μM | SANGER | |||
| BHY | Growth Inhibition Assay | IC50=0.00216 μM | SANGER | |||
| SW756 | Growth Inhibition Assay | IC50=0.00216 μM | SANGER | |||
| TE-1 | Growth Inhibition Assay | IC50=0.00216 μM | SANGER | |||
| NCI-H2452 | Growth Inhibition Assay | IC50=0.00216 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=0.00217 μM | SANGER | |||
| COR-L23 | Growth Inhibition Assay | IC50=0.0022 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=0.00222 μM | SANGER | |||
| BFTC-909 | Growth Inhibition Assay | IC50=0.00225 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.00225 μM | SANGER | |||
| NCI-H650 | Growth Inhibition Assay | IC50=0.00225 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.00226 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=0.00227 μM | SANGER | |||
| TYK-nu | Growth Inhibition Assay | IC50=0.00232 μM | SANGER | |||
| JVM-3 | Growth Inhibition Assay | IC50=0.00233 μM | SANGER | |||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.00233 μM | SANGER | |||
| SK-HEP-1 | Growth Inhibition Assay | IC50=0.00234 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.00235 μM | SANGER | |||
| A673 | Growth Inhibition Assay | IC50=0.00235 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=0.00243 μM | SANGER | |||
| RPMI-2650 | Growth Inhibition Assay | IC50=0.00246 μM | SANGER | |||
| HCE-4 | Growth Inhibition Assay | IC50=0.00247 μM | SANGER | |||
| KGN | Growth Inhibition Assay | IC50=0.00247 μM | SANGER | |||
| U251 | Growth Inhibition Assay | IC50=0.0025 μM | SANGER | |||
| BxPC-3 | Growth Inhibition Assay | IC50=0.00251 μM | SANGER | |||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.00252 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=0.00254 μM | SANGER | |||
| OC-314 | Growth Inhibition Assay | IC50=0.00256 μM | SANGER | |||
| NCI-H1437 | Growth Inhibition Assay | IC50=0.0026 μM | SANGER | |||
| SNU-387 | Growth Inhibition Assay | IC50=0.00261 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=0.00265 μM | SANGER | |||
| C-33-A | Growth Inhibition Assay | IC50=0.00266 μM | SANGER | |||
| CAL-51 | Growth Inhibition Assay | IC50=0.00271 μM | SANGER | |||
| Hs-578-T | Growth Inhibition Assay | IC50=0.00272 μM | SANGER | |||
| MDA-MB-415 | Growth Inhibition Assay | IC50=0.00274 μM | SANGER | |||
| SW1417 | Growth Inhibition Assay | IC50=0.00276 μM | SANGER | |||
| HCC70 | Growth Inhibition Assay | IC50=0.00277 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=0.00277 μM | SANGER | |||
| KYSE-270 | Growth Inhibition Assay | IC50=0.00278 μM | SANGER | |||
| HT-29 | Growth Inhibition Assay | IC50=0.0028 μM | SANGER | |||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.00281 μM | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | IC50=0.00281 μM | SANGER | |||
| JEG-3 | Growth Inhibition Assay | IC50=0.00282 μM | SANGER | |||
| HT-3 | Growth Inhibition Assay | IC50=0.00282 μM | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | IC50=0.00285 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=0.00286 μM | SANGER | |||
| SKG-IIIa | Growth Inhibition Assay | IC50=0.00286 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=0.00293 μM | SANGER | |||
| LCLC-103H | Growth Inhibition Assay | IC50=0.00293 μM | SANGER | |||
| DOK | Growth Inhibition Assay | IC50=0.00294 μM | SANGER | |||
| SW1088 | Growth Inhibition Assay | IC50=0.00295 μM | SANGER | |||
| GP5d | Growth Inhibition Assay | IC50=0.00296 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=0.00298 μM | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | IC50=0.003 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=0.00301 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=0.00302 μM | SANGER | |||
| HEC-1 | Growth Inhibition Assay | IC50=0.00303 μM | SANGER | |||
| U031 | Growth Inhibition Assay | IC50=0.00307 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=0.00308 μM | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | IC50=0.00308 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=0.00312 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=0.00314 μM | SANGER | |||
| 22RV1 | Growth Inhibition Assay | IC50=0.00315 μM | SANGER | |||
| MKN28 | Growth Inhibition Assay | IC50=0.00317 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=0.00322 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=0.00322 μM | SANGER | |||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.00324 μM | SANGER | |||
| CaR-1 | Growth Inhibition Assay | IC50=0.00327 μM | SANGER | |||
| AGS | Growth Inhibition Assay | IC50=0.00328 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=0.00329 μM | SANGER | |||
| UACC-62 | Growth Inhibition Assay | IC50=0.0033 μM | SANGER | |||
| NCI-H28 | Growth Inhibition Assay | IC50=0.00334 μM | SANGER | |||
| A2780 | Growth Inhibition Assay | IC50=0.00335 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=0.00337 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=0.0034 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=0.00342 μM | SANGER | |||
| HuO9 | Growth Inhibition Assay | IC50=0.00346 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=0.00348 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=0.00355 μM | SANGER | |||
| U-87-MG | Growth Inhibition Assay | IC50=0.00355 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=0.00358 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=0.00359 μM | SANGER | |||
| EGI-1 | Growth Inhibition Assay | IC50=0.00362 μM | SANGER | |||
| NCI-H23 | Growth Inhibition Assay | IC50=0.00364 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=0.00368 μM | SANGER | |||
| NCI-H520 | Growth Inhibition Assay | IC50=0.00372 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=0.00376 μM | SANGER | |||
| CAL-12T | Growth Inhibition Assay | IC50=0.00376 μM | SANGER | |||
| BT-20 | Growth Inhibition Assay | IC50=0.00376 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=0.00381 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=0.0039 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=0.00393 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=0.00396 μM | SANGER | |||
| SW620 | Growth Inhibition Assay | IC50=0.00397 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=0.00399 μM | SANGER | |||
| RD | Growth Inhibition Assay | IC50=0.004 μM | SANGER | |||
| HLE | Growth Inhibition Assay | IC50=0.00405 μM | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.00407 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=0.00408 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=0.00408 μM | SANGER | |||
| D-502MG | Growth Inhibition Assay | IC50=0.0041 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=0.00412 μM | SANGER | |||
| LS-123 | Growth Inhibition Assay | IC50=0.00425 μM | SANGER | |||
| SiHa | Growth Inhibition Assay | IC50=0.0043 μM | SANGER | |||
| T47D | Growth Inhibition Assay | IC50=0.00431 μM | SANGER | |||
| EW-24 | Growth Inhibition Assay | IC50=0.00433 μM | SANGER | |||
| CAL-120 | Growth Inhibition Assay | IC50=0.00435 μM | SANGER | |||
| JAR | Growth Inhibition Assay | IC50=0.00437 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.00438 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=0.00438 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=0.00447 μM | SANGER | |||
| MDA-MB-453 | Growth Inhibition Assay | IC50=0.00451 μM | SANGER | |||
| MKN45 | Growth Inhibition Assay | IC50=0.00453 μM | SANGER | |||
| ECC10 | Growth Inhibition Assay | IC50=0.0046 μM | SANGER | |||
| RVH-421 | Growth Inhibition Assay | IC50=0.00461 μM | SANGER | |||
| TGBC11TKB | Growth Inhibition Assay | IC50=0.00469 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=0.00471 μM | SANGER | |||
| LN-405 | Growth Inhibition Assay | IC50=0.00482 μM | SANGER | |||
| S-117 | Growth Inhibition Assay | IC50=0.00486 μM | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.00497 μM | SANGER | |||
| KYSE-150 | Growth Inhibition Assay | IC50=0.00499 μM | SANGER | |||
| NCI-H1666 | Growth Inhibition Assay | IC50=0.00505 μM | SANGER | |||
| Mewo | Growth Inhibition Assay | IC50=0.00505 μM | SANGER | |||
| AN3-CA | Growth Inhibition Assay | IC50=0.00507 μM | SANGER | |||
| COLO-680N | Growth Inhibition Assay | IC50=0.00508 μM | SANGER | |||
| FADU | Growth Inhibition Assay | IC50=0.0051 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=0.00511 μM | SANGER | |||
| KASUMI-1 | Growth Inhibition Assay | IC50=0.00511 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=0.00513 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=0.0053 μM | SANGER | |||
| RO82-W-1 | Growth Inhibition Assay | IC50=0.00531 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.00531 μM | SANGER | |||
| NCI-H2170 | Growth Inhibition Assay | IC50=0.00535 μM | SANGER | |||
| SK-N-AS | Growth Inhibition Assay | IC50=0.00535 μM | SANGER | |||
| NCI-H1651 | Growth Inhibition Assay | IC50=0.0054 μM | SANGER | |||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=0.00545 μM | SANGER | |||
| SN12C | Growth Inhibition Assay | IC50=0.0055 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=0.00551 μM | SANGER | |||
| SW1573 | Growth Inhibition Assay | IC50=0.00554 μM | SANGER | |||
| OE19 | Growth Inhibition Assay | IC50=0.00559 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=0.00567 μM | SANGER | |||
| HuCCT1 | Growth Inhibition Assay | IC50=0.00568 μM | SANGER | |||
| SW1783 | Growth Inhibition Assay | IC50=0.0057 μM | SANGER | |||
| 8305C | Growth Inhibition Assay | IC50=0.00576 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.00586 μM | SANGER | |||
| MMAC-SF | Growth Inhibition Assay | IC50=0.00586 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=0.0059 μM | SANGER | |||
| HCC38 | Growth Inhibition Assay | IC50=0.006 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=0.00601 μM | SANGER | |||
| NCI-H1573 | Growth Inhibition Assay | IC50=0.00607 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=0.00616 μM | SANGER | |||
| NCI-H810 | Growth Inhibition Assay | IC50=0.00622 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=0.00623 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=0.00624 μM | SANGER | |||
| NCI-H1755 | Growth Inhibition Assay | IC50=0.00624 μM | SANGER | |||
| KYSE-70 | Growth Inhibition Assay | IC50=0.00624 μM | SANGER | |||
| SW626 | Growth Inhibition Assay | IC50=0.00624 μM | SANGER | |||
| WM-115 | Growth Inhibition Assay | IC50=0.00627 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=0.00629 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=0.0063 μM | SANGER | |||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.00639 μM | SANGER | |||
| IGR-1 | Growth Inhibition Assay | IC50=0.00641 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=0.00644 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.00652 μM | SANGER | |||
| HC-1 | Growth Inhibition Assay | IC50=0.00656 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=0.00658 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.00679 μM | SANGER | |||
| HuP-T4 | Growth Inhibition Assay | IC50=0.00679 μM | SANGER | |||
| AsPC-1 | Growth Inhibition Assay | IC50=0.00683 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=0.00689 μM | SANGER | |||
| CP50-MEL-B | Growth Inhibition Assay | IC50=0.00693 μM | SANGER | |||
| DMS-114 | Growth Inhibition Assay | IC50=0.00696 μM | SANGER | |||
| KYSE-520 | Growth Inhibition Assay | IC50=0.007 μM | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | IC50=0.00725 μM | SANGER | |||
| COLO-829 | Growth Inhibition Assay | IC50=0.00725 μM | SANGER | |||
| NCI-H2052 | Growth Inhibition Assay | IC50=0.00727 μM | SANGER | |||
| HOP-92 | Growth Inhibition Assay | IC50=0.0073 μM | SANGER | |||
| MDA-MB-231 | Growth Inhibition Assay | IC50=0.0073 μM | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | IC50=0.00732 μM | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | IC50=0.00748 μM | SANGER | |||
| SW900 | Growth Inhibition Assay | IC50=0.00755 μM | SANGER | |||
| NCI-H358 | Growth Inhibition Assay | IC50=0.00758 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=0.00773 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=0.00781 μM | SANGER | |||
| 786-0 | Growth Inhibition Assay | IC50=0.00786 μM | SANGER | |||
| no-10 | Growth Inhibition Assay | IC50=0.00788 μM | SANGER | |||
| SCH | Growth Inhibition Assay | IC50=0.00818 μM | SANGER | |||
| COLO-741 | Growth Inhibition Assay | IC50=0.0082 μM | SANGER | |||
| NCI-H82 | Growth Inhibition Assay | IC50=0.00822 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=0.00827 μM | SANGER | |||
| IST-MES1 | Growth Inhibition Assay | IC50=0.0084 μM | SANGER | |||
| NCI-H1623 | Growth Inhibition Assay | IC50=0.00856 μM | SANGER | |||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.00857 μM | SANGER | |||
| SNU-423 | Growth Inhibition Assay | IC50=0.00857 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=0.0086 μM | SANGER | |||
| DK-MG | Growth Inhibition Assay | IC50=0.0086 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.0088 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=0.00906 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=0.0091 μM | SANGER | |||
| DBTRG-05MG | Growth Inhibition Assay | IC50=0.00917 μM | SANGER | |||
| HPAF-II | Growth Inhibition Assay | IC50=0.00926 μM | SANGER | |||
| A204 | Growth Inhibition Assay | IC50=0.00934 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=0.00977 μM | SANGER | |||
| BHT-101 | Growth Inhibition Assay | IC50=0.0098 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=0.00983 μM | SANGER | |||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.00988 μM | SANGER | |||
| NCI-H661 | Growth Inhibition Assay | IC50=0.01005 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=0.01024 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=0.01029 μM | SANGER | |||
| TCCSUP | Growth Inhibition Assay | IC50=0.01036 μM | SANGER | |||
| SW1990 | Growth Inhibition Assay | IC50=0.01047 μM | SANGER | |||
| HCC1395 | Growth Inhibition Assay | IC50=0.01056 μM | SANGER | |||
| PANC-10-05 | Growth Inhibition Assay | IC50=0.01056 μM | SANGER | |||
| CAKI-1 | Growth Inhibition Assay | IC50=0.01073 μM | SANGER | |||
| HuP-T3 | Growth Inhibition Assay | IC50=0.01077 μM | SANGER | |||
| HT-1197 | Growth Inhibition Assay | IC50=0.01084 μM | SANGER | |||
| MOLT-13 | Growth Inhibition Assay | IC50=0.01086 μM | SANGER | |||
| NCI-H1563 | Growth Inhibition Assay | IC50=0.01087 μM | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | IC50=0.01093 μM | SANGER | |||
| LB373-MEL-D | Growth Inhibition Assay | IC50=0.01094 μM | SANGER | |||
| EFO-21 | Growth Inhibition Assay | IC50=0.011 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=0.01102 μM | SANGER | |||
| DU-145 | Growth Inhibition Assay | IC50=0.01107 μM | SANGER | |||
| SF295 | Growth Inhibition Assay | IC50=0.01126 μM | SANGER | |||
| ABC-1 | Growth Inhibition Assay | IC50=0.01146 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=0.01148 μM | SANGER | |||
| GAK | Growth Inhibition Assay | IC50=0.01158 μM | SANGER | |||
| LU-139 | Growth Inhibition Assay | IC50=0.01166 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=0.01169 μM | SANGER | |||
| MSTO-211H | Growth Inhibition Assay | IC50=0.01173 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=0.01198 μM | SANGER | |||
| NCI-H441 | Growth Inhibition Assay | IC50=0.01198 μM | SANGER | |||
| LU-99A | Growth Inhibition Assay | IC50=0.012 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=0.01209 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=0.01229 μM | SANGER | |||
| YAPC | Growth Inhibition Assay | IC50=0.01237 μM | SANGER | |||
| HT55 | Growth Inhibition Assay | IC50=0.01242 μM | SANGER | |||
| NB7 | Growth Inhibition Assay | IC50=0.01243 μM | SANGER | |||
| NCI-H2030 | Growth Inhibition Assay | IC50=0.01254 μM | SANGER | |||
| EW-22 | Growth Inhibition Assay | IC50=0.01256 μM | SANGER | |||
| UMC-11 | Growth Inhibition Assay | IC50=0.01283 μM | SANGER | |||
| MKN7 | Growth Inhibition Assay | IC50=0.01283 μM | SANGER | |||
| OE33 | Growth Inhibition Assay | IC50=0.013 μM | SANGER | |||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.01324 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=0.01328 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=0.0133 μM | SANGER | |||
| HuH-7 | Growth Inhibition Assay | IC50=0.01354 μM | SANGER | |||
| J82 | Growth Inhibition Assay | IC50=0.0139 μM | SANGER | |||
| CFPAC-1 | Growth Inhibition Assay | IC50=0.01406 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=0.01429 μM | SANGER | |||
| A704 | Growth Inhibition Assay | IC50=0.01438 μM | SANGER | |||
| SW684 | Growth Inhibition Assay | IC50=0.01452 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=0.0146 μM | SANGER | |||
| U-118-MG | Growth Inhibition Assay | IC50=0.0147 μM | SANGER | |||
| NCI-H596 | Growth Inhibition Assay | IC50=0.01477 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=0.01516 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=0.01523 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=0.01545 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=0.01549 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=0.016 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=0.01609 μM | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | IC50=0.01636 μM | SANGER | |||
| T-24 | Growth Inhibition Assay | IC50=0.01705 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=0.01737 μM | SANGER | |||
| NCI-H2291 | Growth Inhibition Assay | IC50=0.01838 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=0.01867 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=0.01887 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=0.01891 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=0.01934 μM | SANGER | |||
| BT-474 | Growth Inhibition Assay | IC50=0.01943 μM | SANGER | |||
| OAW-28 | Growth Inhibition Assay | IC50=0.01956 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=0.02008 μM | SANGER | |||
| PC-3 | Growth Inhibition Assay | IC50=0.02036 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=0.02054 μM | SANGER | |||
| D-392MG | Growth Inhibition Assay | IC50=0.02068 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=0.02161 μM | SANGER | |||
| LoVo | Growth Inhibition Assay | IC50=0.02172 μM | SANGER | |||
| HCC1954 | Growth Inhibition Assay | IC50=0.02192 μM | SANGER | |||
| COLO-792 | Growth Inhibition Assay | IC50=0.02196 μM | SANGER | |||
| KLE | Growth Inhibition Assay | IC50=0.02323 μM | SANGER | |||
| MDA-MB-157 | Growth Inhibition Assay | IC50=0.02349 μM | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | IC50=0.02465 μM | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | IC50=0.02474 μM | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | IC50=0.02477 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=0.02502 μM | SANGER | |||
| MKN1 | Growth Inhibition Assay | IC50=0.02576 μM | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | IC50=0.02654 μM | SANGER | |||
| RMG-I | Growth Inhibition Assay | IC50=0.027 μM | SANGER | |||
| NB12 | Growth Inhibition Assay | IC50=0.0272 μM | SANGER | |||
| RCM-1 | Growth Inhibition Assay | IC50=0.02819 μM | SANGER | |||
| C3A | Growth Inhibition Assay | IC50=0.02822 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=0.02837 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=0.02837 μM | SANGER | |||
| EW-13 | Growth Inhibition Assay | IC50=0.02904 μM | SANGER | |||
| CAL-72 | Growth Inhibition Assay | IC50=0.02918 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=0.02998 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=0.0303 μM | SANGER | |||
| OAW-42 | Growth Inhibition Assay | IC50=0.0303 μM | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | IC50=0.03052 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=0.03063 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=0.03169 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=0.03185 μM | SANGER | |||
| SW1463 | Growth Inhibition Assay | IC50=0.03337 μM | SANGER | |||
| MEL-HO | Growth Inhibition Assay | IC50=0.03421 μM | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | IC50=0.03633 μM | SANGER | |||
| ACHN | Growth Inhibition Assay | IC50=0.0371 μM | SANGER | |||
| RH-18 | Growth Inhibition Assay | IC50=0.03763 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=0.0379 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.03869 μM | SANGER | |||
| KP-N-YN | Growth Inhibition Assay | IC50=0.03876 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=0.03887 μM | SANGER | |||
| LU-65 | Growth Inhibition Assay | IC50=0.03904 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=0.03952 μM | SANGER | |||
| HT | Growth Inhibition Assay | IC50=0.04007 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=0.04095 μM | SANGER | |||
| NCI-H1693 | Growth Inhibition Assay | IC50=0.04305 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=0.04335 μM | SANGER | |||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=0.04417 μM | SANGER | |||
| KMOE-2 | Growth Inhibition Assay | IC50=0.04469 μM | SANGER | |||
| DMS-79 | Growth Inhibition Assay | IC50=0.04579 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=0.04614 μM | SANGER | |||
| NCI-H69 | Growth Inhibition Assay | IC50=0.04849 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=0.0501 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=0.05067 μM | SANGER | |||
| NCI-H1793 | Growth Inhibition Assay | IC50=0.05093 μM | SANGER | |||
| HT-1376 | Growth Inhibition Assay | IC50=0.05186 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=0.05384 μM | SANGER | |||
| Capan-2 | Growth Inhibition Assay | IC50=0.05396 μM | SANGER | |||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.05446 μM | SANGER | |||
| UACC-893 | Growth Inhibition Assay | IC50=0.05462 μM | SANGER | |||
| SK-MEL-3 | Growth Inhibition Assay | IC50=0.05788 μM | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | IC50=0.058 μM | SANGER | |||
| SW948 | Growth Inhibition Assay | IC50=0.05996 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=0.06167 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=0.06244 μM | SANGER | |||
| KU-19-19 | Growth Inhibition Assay | IC50=0.06361 μM | SANGER | |||
| A431 | Growth Inhibition Assay | IC50=0.06374 μM | SANGER | |||
| NCI-H2405 | Growth Inhibition Assay | IC50=0.06383 μM | SANGER | |||
| KARPAS-299 | Growth Inhibition Assay | IC50=0.06582 μM | SANGER | |||
| BALL-1 | Growth Inhibition Assay | IC50=0.06674 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=0.07073 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=0.07369 μM | SANGER | |||
| MFE-280 | Growth Inhibition Assay | IC50=0.07536 μM | SANGER | |||
| HOP-62 | Growth Inhibition Assay | IC50=0.07676 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=0.07787 μM | SANGER | |||
| CW-2 | Growth Inhibition Assay | IC50=0.07832 μM | SANGER | |||
| SW837 | Growth Inhibition Assay | IC50=0.08342 μM | SANGER | |||
| MFH-ino | Growth Inhibition Assay | IC50=0.08501 μM | SANGER | |||
| HCC1419 | Growth Inhibition Assay | IC50=0.08987 μM | SANGER | |||
| HMV-II | Growth Inhibition Assay | IC50=0.0901 μM | SANGER | |||
| BEN | Growth Inhibition Assay | IC50=0.09385 μM | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | IC50=0.09556 μM | SANGER | |||
| JVM-2 | Growth Inhibition Assay | IC50=0.09716 μM | SANGER | |||
| CAL-54 | Growth Inhibition Assay | IC50=0.1004 μM | SANGER | |||
| T84 | Growth Inhibition Assay | IC50=0.10952 μM | SANGER | |||
| SHP-77 | Growth Inhibition Assay | IC50=0.11641 μM | SANGER | |||
| G-361 | Growth Inhibition Assay | IC50=0.12324 μM | SANGER | |||
| Calu-3 | Growth Inhibition Assay | IC50=0.13816 μM | SANGER | |||
| HCC1937 | Growth Inhibition Assay | IC50=0.14937 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=0.1501 μM | SANGER | |||
| 769-P | Growth Inhibition Assay | IC50=0.15843 μM | SANGER | |||
| NCI-H1304 | Growth Inhibition Assay | IC50=0.16061 μM | SANGER | |||
| D-542MG | Growth Inhibition Assay | IC50=0.16278 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=0.17441 μM | SANGER | |||
| NCI-H2029 | Growth Inhibition Assay | IC50=0.20243 μM | SANGER | |||
| ZR-75-30 | Growth Inhibition Assay | IC50=0.20643 μM | SANGER | |||
| SW1116 | Growth Inhibition Assay | IC50=0.21117 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.27614 μM | SANGER | |||
| LU-135 | Growth Inhibition Assay | IC50=0.27739 μM | SANGER | |||
| MC116 | Growth Inhibition Assay | IC50=0.28309 μM | SANGER | |||
| LS-513 | Growth Inhibition Assay | IC50=0.28773 μM | SANGER | |||
| NCI-H630 | Growth Inhibition Assay | IC50=0.29376 μM | SANGER | |||
| L-428 | Growth Inhibition Assay | IC50=0.29883 μM | SANGER | |||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.31291 μM | SANGER | |||
| NCI-H1838 | Growth Inhibition Assay | IC50=0.31784 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=0.3224 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=0.32298 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=0.33477 μM | SANGER | |||
| IGROV-1 | Growth Inhibition Assay | IC50=0.33755 μM | SANGER | |||
| Mo-T | Growth Inhibition Assay | IC50=0.33853 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=0.339 μM | SANGER | |||
| HCC1569 | Growth Inhibition Assay | IC50=0.34309 μM | SANGER | |||
| COLO-678 | Growth Inhibition Assay | IC50=0.37002 μM | SANGER | |||
| COR-L105 | Growth Inhibition Assay | IC50=0.3793 μM | SANGER | |||
| SK-MEL-24 | Growth Inhibition Assay | IC50=0.38382 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=0.43976 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=0.49023 μM | SANGER | |||
| COLO-679 | Growth Inhibition Assay | IC50=0.62172 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=0.65394 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=0.6622 μM | SANGER | |||
| H-EMC-SS | Growth Inhibition Assay | IC50=0.70546 μM | SANGER | |||
| SNU-449 | Growth Inhibition Assay | IC50=0.72748 μM | SANGER | |||
| C32 | Growth Inhibition Assay | IC50=0.74112 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=0.77024 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=0.78781 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=0.79183 μM | SANGER | |||
| CAL-85-1 | Growth Inhibition Assay | IC50=0.907 μM | SANGER | |||
| NY | Growth Inhibition Assay | IC50=0.93352 μM | SANGER | |||
| NCI-H1993 | Growth Inhibition Assay | IC50=1.19289 μM | SANGER | |||
| SK-OV-3 | Growth Inhibition Assay | IC50=1.22089 μM | SANGER | |||
| Click to View More Cell Line Experimental Data | ||||||
Biological Activity
| Description | Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. | |
|---|---|---|
| Targets |
|
| In vitro | ||||
| In vitro | Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8] | |||
|---|---|---|---|---|
| Cell Research | Cell lines | Human gastric cancer cell lines MKN-28 | ||
| Concentrations | 6 nM | |||
| Incubation Time | 3 days | |||
| Method | 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader. | |||
| Experimental Result Images | Methods | Biomarkers | Images | PMID |
| Western blot | PIM1 cyclin B pSTAT3 / STAT3 p-p53 / p53 |
|
18426800 | |
| Immunofluorescence | α-tubulin cleaved PARP / cleaved caspase-3 Acetylated tubulin SQSTM1 / LAMP1 |
|
27177833 | |
| Growth inhibition assay | Cell viability |
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22996738 | |
| In Vivo | ||
| In vivo | Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7] | |
|---|---|---|
| Animal Research | Animal Models | Human colon carcinomas xenografts CX-1 |
| Dosages | 33 mg/kg | |
| Administration | i.v. every 4 days for 3 injections | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05156372 | Not yet recruiting | Prostate Cancer Metastatic|Castrate Resistant Prostate Cancer|Metastatic Prostate Cancer|Metastatic Prostate Adenocarcinoma | The University of Texas Health Science Center at San Antonio | December 2023 | Not Applicable |
| NCT05863325 | Recruiting | Locally Advanced or Metastatic Non-Small Cell Lung Cancer | CSPC ZhongQi Pharmaceutical Technology Co. Ltd. | June 27 2023 | Phase 2 |
| NCT05858398 | Not yet recruiting | Breast Cancer | Centre Henri Becquerel|Erasmus Medical Center|Universitaire Ziekenhuizen KU Leuven | May 30 2023 | Not Applicable |
Chemical lnformation & Solubility
| Molecular Weight | 807.88 | Formula | C43H53NO14 |
| CAS No. | 114977-28-5 | SDF | Download Docetaxel SDF |
| Smiles | CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O | ||
| Storage (From the date of receipt) | |||
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In vitro |
DMSO : 100 mg/mL ( (123.78 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Ethanol : 100 mg/mL Water : Insoluble |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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