Home Metabolism PPAR agonist - P450 (e.g. CYP17) inhibitor - Autophagy activator Fenofibrate For research use only.

Fenofibrate

Synonyms: NSC-281319

Fenofibrate is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.

Fenofibrate Chemical Structure

Fenofibrate Chemical Structure

CAS: 49562-28-9

Selleck's Fenofibrate has been cited by 13 Publications

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Purity & Quality Control

Batch: Purity: 99.99%
99.99

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Biological Activity

Description Fenofibrate is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.
Targets
PPARα [1] CYP2C19 [3]
(Cell-free assay)		 CYP2B6 [3]
(Cell-free assay)		 CYP2C9 [3]
(Cell-free assay)
0.2 μM 0.7 μM 9.7 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05514119 Recruiting Liver Transplant Mayo Clinic August 17 2022 Phase 2
NCT04650152 Completed Hypertriglyceridemia|Metabolic Syndrome Abbott October 27 2020 --
NCT03869931 Unknown status Diabetes Mellitus|Diabetic Nephropathies Singapore General Hospital|National Medical Research Council (NMRC) Singapore March 8 2019 Phase 3
NCT03557983 Unknown status Radiodermatitis Second Affiliated Hospital of Soochow University June 13 2018 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 360.83 Formula

C20H21ClO4
CAS No. 49562-28-9 SDF Download Fenofibrate SDF
Smiles CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 72 mg/mL ( (199.53 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 72 mg/mL

Water : Insoluble


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