Home Immunology & Inflammation Immunology & Inflammation related chemical Flurbiprofen For research use only.

Flurbiprofen

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).

Flurbiprofen Chemical Structure

Flurbiprofen Chemical Structure

CAS: 5104-49-4

Purity & Quality Control

Batch: Purity: 99.99%
99.99

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Biological Activity

Description Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).
In vitro
In vitro Flurbiprofen effectively inhibits the growth of various tumor cells in a dose-dependent manner and causes a noticeable change in the progression of cells through cell cycle stages in tumor cell lines derived from medulloblastoma and glioblastoma multiforme. Flurbiprofen reduces the number of cells in G1 and G2, and significantly increases their numbers in S phase, suggesting that, Flurbiprofen accelerates G1/S entry, and/or delays cell exit from S to G2/M stages. Flurbiprofen causes a minor change in the RNA level of different cyclins, there is a significant decrease in the level of cyclin B protein upon flurbiprofen treatment. [1]
In Vivo
In vivo Flurbiprofen affords significant neuroprotection from ischemic injury as evidenced by reduction in cerebral infarct volume and neurobehavioral deficit. Flurbiprofen significantly reduces an early calcium dependent rise in levels of nitrite and MDA in ischemic brain regions of rats. Flurbiprofen also reduces the proteolytic products (SBDPs) caused by ischemic activation of calcium dependent protease calpain. [2] Flurbiprofen (5 mg/kg and 10mg/kg) significantly attenuates brain ischemia/reperfusion injury in rats, as shown by a reduction in the infarct volume, neurological deficit scores and cell apoptosis. Flurbiprofen not only inhibits the expression of Bax protein and p-GSK-3β, but also increases the expression of Bcl-2 protein, the ratio of Bcl-2/Bax as well as the P-Akt level in rats. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05901389 Not yet recruiting Lidocaine|Analgesia|Pain Postoperative|Thoracic Surgery Qilu Hospital of Shandong University June 2023 Not Applicable
NCT05622656 Recruiting Pain Postoperative First People''s Hospital of Chenzhou December 1 2022 Phase 4
NCT05368831 Not yet recruiting Healthy Volunteers NorthSea Therapeutics B.V. July 2022 Phase 1
NCT04805775 Completed Desflurane|Propofol|Postoperative Sleep|PSQI|Breast Tumor Zhongnan Hospital October 21 2021 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 244.26 Formula

C15H13FO2
CAS No. 5104-49-4 SDF Download Flurbiprofen SDF
Smiles CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 48 mg/mL ( (196.51 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 48 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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