Home Neuronal Signaling ADC Cytotoxin inhibitor - AChR inhibitor Galanthamine HBr For research use only.

Galanthamine HBr

Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.

Galanthamine HBr Chemical Structure

Galanthamine HBr Chemical Structure

CAS: 1953-04-4

Selleck's Galanthamine HBr has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.90%
99.90

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Biological Activity

Description Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.
Targets
AChE [1]
0.35 μM
In vitro
In vitro Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. [1] Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). [2] Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells. [3]
In Vivo
In vivo Galantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia. [4]
Animal Research Animal Models Gerbils
Dosages 10 mg/kg
Administration S.c. twice a day or 3 or 6 hours after ischemia and at subsequent 12-hours intervals until sacrifice

Chemical lnformation & Solubility

Molecular Weight 368.27 Formula

C17H21NO3.HBr
CAS No. 1953-04-4 SDF Download Galanthamine HBr SDF
Smiles CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O.Br
Storage (From the date of receipt)

In vitro
Batch:

Water : 10 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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