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Guaifenesin

Guaifenesin is an expectorant used to relieve chest congestion.

Guaifenesin Chemical Structure

Guaifenesin Chemical Structure

CAS: 93-14-1

Purity & Quality Control

Batch: S174001 DMSO] 40 mg/mL] false] Ethanol] 40 mg/mL] false] Water] 25 mg/mL] false Purity: 99.92%
99.92

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Biological Activity

Description Guaifenesin is an expectorant used to relieve chest congestion.
In Vivo
In vivo Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. Guaifenesin (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. [1] Guaifenesin (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves. [2] Guaifenesin (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs. [3] Guaifenesin prevents adverse anesthetic induction events caused by Propofol in horse. Guaifenesin (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize > 99% of calm healthy adult horses. [4] Guaifenesin (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. Guaifenesin (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03642262 Completed Healthy Subjects Reckitt Benckiser Inc.|Reckitt Benckiser LLC June 2 2013 Phase 1
NCT03649750 Completed Healthy Subjects Reckitt Benckiser LLC May 29 2013 Phase 1
NCT03633487 Completed Healthy Subjects Reckitt Benckiser LLC October 11 2011 Phase 1

Chemical lnformation & Solubility

Molecular Weight 198.22 Formula

C10H14O4

CAS No. 93-14-1 SDF Download Guaifenesin SDF
Smiles COC1=CC=CC=C1OCC(CO)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 40 mg/mL ( (201.79 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 40 mg/mL

Water : 25 mg/mL


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