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Indocyanine green

Name: Indocyanine green
Brand: Selleck Chemicals
SKU: S1924
Rating: 5 (1 reviews)

Synonyms: Cardiogreen

Catalog No.S1924 Purity: 98.80%

Indocyanine green(Cardiogreen) is a cyanine dye that binds to plasma proteins and lipoproteins. It is used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. Indocyanine green-photodynamic therapy(ICG-PDT) induces apoptosis in HGF cells at transcriptome level.

Indocyanine green Chemical Structure

CAS: 3599-32-4

Selleck's Indocyanine green has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 98.80%

98.80

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Biological Activity

Description	Indocyanine green(Cardiogreen) is a cyanine dye that binds to plasma proteins and lipoproteins. It is used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. Indocyanine green-photodynamic therapy(ICG-PDT) induces apoptosis in HGF cells at transcriptome level.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT04723810	Not yet recruiting	Tumor Solid	University of Pennsylvania	December 23 2023	Phase 1\|Phase 2
NCT05645523	Recruiting	Solid Tumor	St. Jude Children''s Research Hospital	October 24 2023	Early Phase 1
NCT05986383	Not yet recruiting	Primary Liver Cancer\|Metastatic Liver Cancer\|Benign Liver Neoplasms\|Hepatic Echinococcosis	Beijing Tsinghua Chang Gung Hospital\|West China Hospital\|Second Affiliated Hospital Sun Yat-Sen University\|The First Hospital of Jilin University\|Meng Chao Hepatobiliary Hospital of Fujian Medical University\|LanZhou University\|Southwest Hospital China\|The Affiliated Hospital of Qingdao University\|Affiliated Hospital of Qinghai University\|The First Affiliated Hospital with Nanjing Medical University\|Shenzhen People''s Hospital\|Zhongshan Hospital Xiamen University	August 2023	--
NCT05709548	Recruiting	Acute Cholecystitis\|Bile Duct Injury	Corporacion Parc Tauli	March 15 2023	Phase 4

References

[1] Gharesi S, et al. Photodiagnosis Photodyn Ther. 2017 Sep;19:33-36.

Chemical lnformation & Solubility

Molecular Weight	774.96	Formula	C₄₃H₄₇N₂NaO₆S₂
CAS No.	3599-32-4	SDF	--
Smiles	CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)CCCCS(=O)(=O)[O-])C=CC=CC=CC=C4C(C5=C(N4CCCCS(=O)(=O)[O-])C=CC6=CC=CC=C65)(C)C)C.[Na+]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (129.03 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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