Home Neuronal Signaling COX inhibitor Ketoprofen For research use only.

Ketoprofen

Synonyms: RP-19583

Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.

Ketoprofen Chemical Structure

Ketoprofen Chemical Structure

CAS: 22071-15-4

Selleck's Ketoprofen has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 100%
100

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Biological Activity

Description Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.
Targets
COX-1 [1] COX-2 [1]
In vitro
In vitro Ketoprofen combined with UVB irradiation induces the cytotoxicity and suppresses DNA synthesis in HaCaT cells in a concentration-dependent manner. Ketoprofen combined with UVB irradiation inhibits the cell growth and induces G2/M cell cycle arrest by modulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. Ketoprofen combined with UVB irradiation also provokes a striking accumulation of cyclin B1-cdc2-p21 complexes, concomitantly with an increase in the levels of Tyr15-phosphorylated cdc2 and p21 protein. Ketoprofen combined with UVB irradiation accentuates the apoptotic response to UVB radiation in HaCaT cells as evidenced by DAPI staining. [1]
In Vivo
In vivo Ketoprofen at 1% level in suitable topical vehicles can effectively inhibit GCF-LTB4 and GCF-PGE2 and positively alter alveolar bone activity in the ligature-induced model of periodontitis in the monkey. [2] Ketoprofen (3.63 mg/kg bwt) reduces hoof pain andlameness to a greater extent than the 2.2 mg/kg dose and phenylbutazone. [3] Ketoprofen is more effective than local anesthesia (LA), or caudal epidural anesthesia (EPI) in decreasing cortisol and partially reverses the reduction in average daily gain (ADG) following castration. [4] Ketoprofen (40 and 80 mg/kg diet) reduces the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04678076 Completed Healthy Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A. July 23 2018 Phase 1
NCT02796547 Withdrawn Episiotomy Brugmann University Hospital July 14 2016 Phase 2
NCT01541059 Completed Third Molar Extraction Centre Hospitalier Universitaire de Nīmes June 2012 Phase 4
NCT01854411 Completed Analgesics Use During Breastfeeding and Concentrations in Human Mature Milk Assistance Publique - Hôpitaux de Paris September 2011 --

Chemical lnformation & Solubility

Molecular Weight 254.28 Formula

C16H14O3
CAS No. 22071-15-4 SDF Download Ketoprofen SDF
Smiles CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 51 mg/mL ( (200.56 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 51 mg/mL

Water : Insoluble


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In vivo
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