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Levonorgestrel

Name: Levonorgestrel
Brand: Selleck Chemicals
SKU: S1727
Rating: 5 (3 reviews)

Synonyms: D-Norgestrel

Catalog No.S1727 Purity: 99.95%

Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.

Levonorgestrel Chemical Structure

CAS: 797-63-7

Selleck's Levonorgestrel has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.95%

99.95

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Biological Activity

Description

Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.

Targets

Progesterone receptor ^[1]

In vitro
In vitro	Levonorgestrel suppresses the stimulation of progesterone secretion induced by oLH, dibutyryl-cAMP and Pregnenolone in rats luteal cells. ^[1] Levonorgestrel also inhibits constrictions evoked by either a high potassium (K(+)) solution or phorbol myristate acetate (PMA) in the absence and presence of extracellular calcium (Ca(2+)). Levonorgestrel depresses contractions evoked by Ca(2+) and reduces (45)Ca(2+) influx in depolarized veins. Levonorgestrel increases levels of cyclic AMP and inhibits PMA-induced activation of protein kinase C in veins. Levonorgestrel causes endothelium-independent relaxations of jugular veins via inhibition of Ca(2+) entry and of protein kinase Cactivation. ^[2] Levonorgestrel inhibition of both estrogen-induced pituitary weight increment and hyperprolactinemia is reduced by mifepristone, whereas Flutamide is unable to block Levonorgestrel effects ^[3]

In Vivo
In vivo	Levonorgestrel down-regulates the mRNA expression of follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) β and progesterone receptor (PR) in the ovary, and ERα and PR in the uterus of Mongolian gerbils. ^[4] Levonorgestrel causes a significant upregulation of the mRNA expression of the gene encoding luteinising hormone β-subunit (lhβ) and the suppression of the mRNA expression of the gene encoding follicle-stimulating hormone β-subunit (fshβ) in the pituitary of both male and female roach. Levonorgestrel disrupts the reproductive system of pubertalroach by affecting the pituitary gonadotropin expression and the sex steroid levels in pubertal roach (Rutilus rutilus). ^[5]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06188026	Recruiting	Healthy Volunteers (Non-alcoholic Steatohepatitis)	Novo Nordisk A/S	December 18 2023	Phase 1
NCT05896384	Recruiting	Healthy	Boehringer Ingelheim	December 7 2023	Phase 1
NCT05700812	Recruiting	IUD\|IUD Insertion Complication\|IUD; Complications	University of California Davis	February 1 2023	Not Applicable
NCT05671653	Terminated	Obesity	Pfizer	January 19 2023	Phase 1

References

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Chemical lnformation & Solubility

Molecular Weight	312.45	Formula	C₂₁H₂₈O₂
CAS No.	797-63-7	SDF	Download Levonorgestrel SDF
Smiles	CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 62 mg/mL ( (198.43 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble

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In vivo
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