Home Protein Tyrosine Kinase ALK inhibitor - Apoptosis related activator TAE684 (NVP-TAE684) For research use only.

TAE684 (NVP-TAE684)

TAE684 (NVP-TAE684) is a potent and selective ALK inhibitor which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM, 100-fold more sensitive for ALK than InsR. TAE684 (NVP-TAE684) induces cell cycle arrest and apoptosis.

TAE684 (NVP-TAE684) Chemical Structure

TAE684 (NVP-TAE684) Chemical Structure

CAS: 761439-42-3

Selleck's TAE684 (NVP-TAE684) has been cited by 82 publications

Purity & Quality Control

Batch: Purity: 99.73%
99.73

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Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SCC-3 Growth Inhibition Assay IC50=0.0000603 μM SANGER
SF539 Growth Inhibition Assay IC50=0.000564 μM SANGER
DEL Growth Inhibition Assay IC50=0.000927 μM SANGER
NB1 Growth Inhibition Assay IC50=0.00162 μM SANGER
SR Growth Inhibition Assay IC50=0.00277 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=0.02384 μM SANGER
MHH-CALL-2 Growth Inhibition Assay IC50=0.02952 μM SANGER
SU-DHL-1 Growth Inhibition Assay IC50=0.04865 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=0.05565 μM SANGER
EW-1 Growth Inhibition Assay IC50=0.10256 μM SANGER
NOS-1 Growth Inhibition Assay IC50=0.10294 μM SANGER
EW-16 Growth Inhibition Assay IC50=0.10568 μM SANGER
TE-11 Growth Inhibition Assay IC50=0.16096 μM SANGER
SW982 Growth Inhibition Assay IC50=0.16478 μM SANGER
LAN-6 Growth Inhibition Assay IC50=0.17443 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=0.17835 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.19343 μM SANGER
PSN1 Growth Inhibition Assay IC50=0.19631 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=0.19692 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=0.19776 μM SANGER
OPM-2 Growth Inhibition Assay IC50=0.22669 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=0.23524 μM SANGER
ALL-PO Growth Inhibition Assay IC50=0.24524 μM SANGER
CMK Growth Inhibition Assay IC50=0.2553 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=0.27855 μM SANGER
SIG-M5 Growth Inhibition Assay IC50=0.29159 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=0.30218 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=0.31204 μM SANGER
NB69 Growth Inhibition Assay IC50=0.31787 μM SANGER
MFH-ino Growth Inhibition Assay IC50=0.32523 μM SANGER
KP-N-RT-BM-1 Growth Inhibition Assay IC50=0.33123 μM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50=0.33291 μM SANGER
ATN-1 Growth Inhibition Assay IC50=0.33303 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=0.33396 μM SANGER
L-540 Growth Inhibition Assay IC50=0.36988 μM SANGER
GB-1 Growth Inhibition Assay IC50=0.38867 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=0.39446 μM SANGER
KG-1 Growth Inhibition Assay IC50=0.39561 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=0.40569 μM SANGER
NEC8 Growth Inhibition Assay IC50=0.41292 μM SANGER
SK-MM-2 Growth Inhibition Assay IC50=0.41609 μM SANGER
TE-8 Growth Inhibition Assay IC50=0.4288 μM SANGER
697 Growth Inhibition Assay IC50=0.43215 μM SANGER
NB14 Growth Inhibition Assay IC50=0.43826 μM SANGER
GDM-1 Growth Inhibition Assay IC50=0.47116 μM SANGER
HUTU-80 Growth Inhibition Assay IC50=0.47375 μM SANGER
HL-60 Growth Inhibition Assay IC50=0.48142 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=0.48328 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.49031 μM SANGER
ES4 Growth Inhibition Assay IC50=0.49109 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=0.4989 μM SANGER
RL95-2 Growth Inhibition Assay IC50=0.50112 μM SANGER
TE-15 Growth Inhibition Assay IC50=0.51124 μM SANGER
TE-12 Growth Inhibition Assay IC50=0.53349 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=0.54549 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=0.55023 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=0.55184 μM SANGER
CTV-1 Growth Inhibition Assay IC50=0.55624 μM SANGER
RXF393 Growth Inhibition Assay IC50=0.55794 μM SANGER
SW872 Growth Inhibition Assay IC50=0.56724 μM SANGER
MPP-89 Growth Inhibition Assay IC50=0.57884 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=0.63526 μM SANGER
LS-1034 Growth Inhibition Assay IC50=0.6358 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=0.63725 μM SANGER
HOP-62 Growth Inhibition Assay IC50=0.65033 μM SANGER
KGN Growth Inhibition Assay IC50=0.66168 μM SANGER
D-336MG Growth Inhibition Assay IC50=0.66169 μM SANGER
LS-411N Growth Inhibition Assay IC50=0.67462 μM SANGER
TE-1 Growth Inhibition Assay IC50=0.69074 μM SANGER
LB996-RCC Growth Inhibition Assay IC50=0.69389 μM SANGER
TE-10 Growth Inhibition Assay IC50=0.71496 μM SANGER
NCI-SNU-16 Growth Inhibition Assay IC50=0.72664 μM SANGER
ES8 Growth Inhibition Assay IC50=0.74975 μM SANGER
COLO-800 Growth Inhibition Assay IC50=0.76695 μM SANGER
ES6 Growth Inhibition Assay IC50=0.77559 μM SANGER
L-363 Growth Inhibition Assay IC50=0.82375 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=0.83233 μM SANGER
LU-134-A Growth Inhibition Assay IC50=0.83912 μM SANGER
SF268 Growth Inhibition Assay IC50=0.84042 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=0.84263 μM SANGER
TGW Growth Inhibition Assay IC50=0.85863 μM SANGER
CHP-126 Growth Inhibition Assay IC50=0.85957 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=0.87589 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=0.89757 μM SANGER
NALM-6 Growth Inhibition Assay IC50=0.90739 μM SANGER
GCIY Growth Inhibition Assay IC50=0.95526 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=0.98824 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.9884 μM SANGER
BL-70 Growth Inhibition Assay IC50=0.99535 μM SANGER
NB17 Growth Inhibition Assay IC50=1.00639 μM SANGER
LXF-289 Growth Inhibition Assay IC50=1.03076 μM SANGER
TK10 Growth Inhibition Assay IC50=1.05063 μM SANGER
K5 Growth Inhibition Assay IC50=1.06274 μM SANGER
NCI-H716 Growth Inhibition Assay IC50=1.07259 μM SANGER
HCE-T Growth Inhibition Assay IC50=1.08819 μM SANGER
GI-1 Growth Inhibition Assay IC50=1.09798 μM SANGER
KARPAS-422 Growth Inhibition Assay IC50=1.10022 μM SANGER
TE-9 Growth Inhibition Assay IC50=1.11328 μM SANGER
SF126 Growth Inhibition Assay IC50=1.11568 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=1.13112 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=1.13338 μM SANGER
HEL Growth Inhibition Assay IC50=1.14895 μM SANGER
HAL-01 Growth Inhibition Assay IC50=1.15283 μM SANGER
SK-LMS-1 Growth Inhibition Assay IC50=1.15974 μM SANGER
SW954 Growth Inhibition Assay IC50=1.19567 μM SANGER
D-283MED Growth Inhibition Assay IC50=1.22379 μM SANGER
NCI-H1882 Growth Inhibition Assay IC50=1.2389 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=1.25208 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=1.26348 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=1.29117 μM SANGER
A704 Growth Inhibition Assay IC50=1.32689 μM SANGER
KALS-1 Growth Inhibition Assay IC50=1.3408 μM SANGER
ETK-1 Growth Inhibition Assay IC50=1.34489 μM SANGER
LB647-SCLC Growth Inhibition Assay IC50=1.34986 μM SANGER
OCUB-M Growth Inhibition Assay IC50=1.36143 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=1.36378 μM SANGER
NB13 Growth Inhibition Assay IC50=1.37293 μM SANGER
GR-ST Growth Inhibition Assay IC50=1.38757 μM SANGER
DU-4475 Growth Inhibition Assay IC50=1.45853 μM SANGER
HCC2157 Growth Inhibition Assay IC50=1.46659 μM SANGER
RKO Growth Inhibition Assay IC50=1.49922 μM SANGER
LS-123 Growth Inhibition Assay IC50=1.51594 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=1.55811 μM SANGER
SW962 Growth Inhibition Assay IC50=1.5613 μM SANGER
PF-382 Growth Inhibition Assay IC50=1.5696 μM SANGER
A101D Growth Inhibition Assay IC50=1.57113 μM SANGER
NB10 Growth Inhibition Assay IC50=1.57392 μM SANGER
NB5 Growth Inhibition Assay IC50=1.58476 μM SANGER
HCE-4 Growth Inhibition Assay IC50=1.6085 μM SANGER
HT-144 Growth Inhibition Assay IC50=1.6319 μM SANGER
NCI-H524 Growth Inhibition Assay IC50=1.64307 μM SANGER
NKM-1 Growth Inhibition Assay IC50=1.6866 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=1.69573 μM SANGER
NCI-H187 Growth Inhibition Assay IC50=1.70036 μM SANGER
U-266 Growth Inhibition Assay IC50=1.73842 μM SANGER
BL-41 Growth Inhibition Assay IC50=1.76272 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=1.78309 μM SANGER
Daudi Growth Inhibition Assay IC50=1.78967 μM SANGER
CPC-N Growth Inhibition Assay IC50=1.85096 μM SANGER
EM-2 Growth Inhibition Assay IC50=1.851 μM SANGER
HCC1187 Growth Inhibition Assay IC50=1.86241 μM SANGER
LP-1 Growth Inhibition Assay IC50=1.87143 μM SANGER
CAS-1 Growth Inhibition Assay IC50=1.98299 μM SANGER
NB7 Growth Inhibition Assay IC50=2.00555 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=2.01513 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=2.03351 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=2.06786 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=2.11559 μM SANGER
IST-SL2 Growth Inhibition Assay IC50=2.12445 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=2.17683 μM SANGER
TE-6 Growth Inhibition Assay IC50=2.1905 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=2.19141 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=2.20041 μM SANGER
LS-513 Growth Inhibition Assay IC50=2.22269 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=2.33256 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=2.37493 μM SANGER
GT3TKB Growth Inhibition Assay IC50=2.39972 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=2.42341 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=2.43674 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=2.47467 μM SANGER
DMS-114 Growth Inhibition Assay IC50=2.61524 μM SANGER
ONS-76 Growth Inhibition Assay IC50=2.63641 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=2.65414 μM SANGER
BOKU Growth Inhibition Assay IC50=2.72764 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=2.79912 μM SANGER
ES1 Growth Inhibition Assay IC50=2.81804 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=2.82012 μM SANGER
A388 Growth Inhibition Assay IC50=2.9617 μM SANGER
NCCIT Growth Inhibition Assay IC50=3.08862 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=3.13203 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=3.18943 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=3.2002 μM SANGER
SCLC-21H Growth Inhibition Assay IC50=3.26859 μM SANGER
SH-4 Growth Inhibition Assay IC50=3.28797 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=3.32849 μM SANGER
KM12 Growth Inhibition Assay IC50=3.33544 μM SANGER
ST486 Growth Inhibition Assay IC50=3.53883 μM SANGER
HC-1 Growth Inhibition Assay IC50=3.62028 μM SANGER
BV-173 Growth Inhibition Assay IC50=3.64088 μM SANGER
EW-24 Growth Inhibition Assay IC50=3.66434 μM SANGER
LU-65 Growth Inhibition Assay IC50=3.6871 μM SANGER
ECC4 Growth Inhibition Assay IC50=3.7756 μM SANGER
ARH-77 Growth Inhibition Assay IC50=4.11067 μM SANGER
BC-3 Growth Inhibition Assay IC50=4.13068 μM SANGER
SNB75 Growth Inhibition Assay IC50=4.2619 μM SANGER
MEG-01 Growth Inhibition Assay IC50=4.27419 μM SANGER
NCI-H1417 Growth Inhibition Assay IC50=4.28443 μM SANGER
MDA-MB-134-VI Growth Inhibition Assay IC50=4.30601 μM SANGER
Becker Growth Inhibition Assay IC50=4.47336 μM SANGER
DMS-153 Growth Inhibition Assay IC50=4.66475 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=4.68515 μM SANGER
EW-3 Growth Inhibition Assay IC50=4.76248 μM SANGER
KE-37 Growth Inhibition Assay IC50=4.86196 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=4.87227 μM SANGER
MC116 Growth Inhibition Assay IC50=4.94126 μM SANGER
NH-12 Growth Inhibition Assay IC50=4.96439 μM SANGER
CTB-1 Growth Inhibition Assay IC50=4.97721 μM SANGER
KM-H2 Growth Inhibition Assay IC50=5.05323 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=5.1183 μM SANGER
NCI-H2141 Growth Inhibition Assay IC50=5.14268 μM SANGER
EB-3 Growth Inhibition Assay IC50=5.17504 μM SANGER
NCI-H1522 Growth Inhibition Assay IC50=5.26322 μM SANGER
MRK-nu-1 Growth Inhibition Assay IC50=5.43633 μM SANGER
no-11 Growth Inhibition Assay IC50=5.47087 μM SANGER
CESS Growth Inhibition Assay IC50=5.58034 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=5.58659 μM SANGER
REH Growth Inhibition Assay IC50=6.25618 μM SANGER
KU812 Growth Inhibition Assay IC50=6.42791 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=6.60674 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=7.06492 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=7.22977 μM SANGER
NCI-H322M Growth Inhibition Assay IC50=7.33335 μM SANGER
NB6 Growth Inhibition Assay IC50=7.54899 μM SANGER
MN-60 Growth Inhibition Assay IC50=7.69215 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=8.01734 μM SANGER
EKVX Growth Inhibition Assay IC50=8.47066 μM SANGER
D-263MG Growth Inhibition Assay IC50=8.55396 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=8.64006 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=8.89892 μM SANGER
ACN Growth Inhibition Assay IC50=9.19157 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=9.21219 μM SANGER
EW-11 Growth Inhibition Assay IC50=9.65396 μM SANGER
KASUMI-1 Growth Inhibition Assay IC50=9.7877 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=10.2347 μM SANGER
EVSA-T Growth Inhibition Assay IC50=10.3192 μM SANGER
DSH1 Growth Inhibition Assay IC50=10.3972 μM SANGER
COLO-824 Growth Inhibition Assay IC50=10.8669 μM SANGER
K052 Growth Inhibition Assay IC50=10.9322 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=10.9939 μM SANGER
Click to View More Cell Line Experimental Data

Biological Activity

Description TAE684 (NVP-TAE684) is a potent and selective ALK inhibitor which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM, 100-fold more sensitive for ALK than InsR. TAE684 (NVP-TAE684) induces cell cycle arrest and apoptosis.
Targets
ALK [1]
(Cell lines)
2-10 nM
In vitro
In vitro

TAE684 does not exhibit significant cross-reactivity against other kinases. TAE684 potently inhibits the proliferation of Ba/F3 NPM-ALK cells with IC50 of 3 nM, without affecting the survival of Ba/F3 cells even at 1 μM. TAE684 also inhibits proliferation of NPM-ALK-expressing human ALCL cell lines including Karpas-299 and SU-DHL-1 with IC50 of 2–5 nM. Molecular modeling reveals that L258 may be one of the major kinase-selectivity determinants for TAE684. TAE684 treatment results in a rapid and sustained inhibition of phosphorylation of NPM-ALK. TAE684 induces apoptosis and G1 phase arrest in NPM-ALK-expressing Ba/F3 cells and ALCL patient cell lines. [1] TAE684 markedly overcomes Crizotinib-resistance in H3122 CR cells, harboring the fusion oncogene EML4-ALK, decreasing cell growth, suppressing ALK phosphorylation and inducing apoptosis.[2] Neurite outgrowth induced by expression of the mALK R1279Q mutant could be completely inhibited by TAE684 at 30 nM. [3]
Kinase Assay In vitro Enzyme Assays.
All in vitro enzyme assays are done at Upstate Biotechnology with the exception of InsR and IGF-1R. To determine the IC50 of TAE684 against InsR and IGF-1R a homogeneous time-resolved fluorescence assay is performed. ATP (10 mM) and 20 mg/ml biotinylated PolyEY (Glu, Tyr 4:1) are combined with 50 nL of serial dilutions of TAE684 (10-500 nM) and 4 ng of InsR enzyme in the presence of the kinase reaction buffer (20 mM Tris譎Cl, pH 7.5/10 mM MgCl2/3 mM MnCl2/1 mM DTT/10 mM NaVO4/0.1 mg/ml of BSA). Assays are incubated for 1 hour at ambient temperature. Reactions are terminated by adding 10 mL of the detection solution containing 50 mM EDTA, 500 mM KF, 0.5 mg/ml of BSA, 5 mg/mL Eu3+ cryptate-labeled anti-phosphotyrosine antibody Mab PT66-K, and 5 mg/mL Streptavidin-XLent. The reaction is incubated for half an hour, and fluorescence signals are read on Analyst GT.
Cell Research Cell lines Luciferase-expressing Karpas-299, SU-DHL-1, and Ba/F3 cells and transformed Ba/F3 stably expressing NPM-ALK, Bcr-Abl, or TEL-kinase fusion constructs.
Concentrations 1 nM-10 μM
Incubation Time 2–3 days
Method

Cells are seeded in 384-well plates (2.5×104 cells per well) and incubated with serial dilutions of TAE684 or DMSO for 2–3 days. Luciferase expression is used as a measure of cell proliferation/survival and is evaluated with the Bright-Glo Luciferase Assay System. IC50 values are generated by using XLFit software.
Experimental Result Images Methods Biomarkers Images PMID
Growth inhibition assay Cell viability 18594010
Western blot p-ROS1 / ROS1 p-ALK / ALK / p-STAT3 / STAT3 / p-ERK / ERK / p-AKT / AKT / Survivin / BIM / PARP 25351743
In Vivo
In vivo

After 4 weeks of treatment with TAE684 at 3 and 10 mg/kg, there is a significant delay in lymphoma development and 100- to 1,000-fold reduction in luminescence signal, without any signs of compound- or disease-related toxicity in Karpas-299 lymphoma model. TAE684 treatment also induces disease regression in established Karpas-299 lymphomas and down-regulates CD30 expression. [1] TAE684 also shows impressive antitumor activity against H3122 CR xenograft tumors. [2] Furthermore, treatment with TAE684 improves the rough eye phenotype of both ALK mutants, especially that seen with ALKR1275Q, whereas Crizotinib has little effect on either phenotype. [3]
Animal Research Animal Models Karpas-299 xenografts are established in 4- to 6-week old female Fox Chase SCIDBeige mice.
Dosages 1, 3, and 10 mg/kg
Administration Once daily by oral gavage for 3 weeks

Chemical lnformation & Solubility

Molecular Weight 614.2 Formula

C30H40ClN7O3S
CAS No. 761439-42-3 SDF Download TAE684 (NVP-TAE684) SDF
Smiles CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 10 mg/mL ( (16.28 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

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%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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