Home Microbiology Fungal inhibitor Natamycin For research use only.

Natamycin

Synonyms: Pimaricin

Natamycin (Pimaricin), a natural and versatile anti-fungal agent during fermentation by the bacterium Streptomyces natalensis, commonly found in soil; with little to no flavour interference

Natamycin Chemical Structure

Natamycin Chemical Structure

CAS: 7681-93-8

Selleck's Natamycin has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.92%
99.92

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Biological Activity

Description Natamycin (Pimaricin), a natural and versatile anti-fungal agent during fermentation by the bacterium Streptomyces natalensis, commonly found in soil; with little to no flavour interference
In vitro
In vitro Natamycin binds specifically to ergosterol present in model membranes. Natamycin does not change the permeability of the yeast plasma membrane under conditions that growth is blocked. [1] Natamycin blocks the fusion of isolated vacuoles without compromising the barrier function of the vacuolar membrane. Natamycin perturbs the cellular vacuole morphology, causing the formation of many more small vacuolar structures in yeast cells. Natamycin inhibits the priming stage of vacuole fusion. [2] Natamycin shows low MIC against the dematiaceous fungi, Curvularia species. [3] Natamycin is complexed with gamma-cyclodextrin (NT-gamma CyD) to increase the solubility and stability of NT in aqueous solutions and reduce the side effects of the drug without decreasing antimycotic activity. [4] MIC90 of Natamycin alone and Natamycin-gamma CyD complexes are below 0.0313 mg/mL, suggesting that complexation with gamma CyD has effectively increased the antimycotic activity of Natamycin, thus indicating the clinical usefulness of Natamycin-gamma CyD complexes. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00997035 Completed Corneal Ulcer|Eye Infections Fungal University of California San Francisco|Aravind Eye Hospitals India|Dartmouth-Hitchcock Medical Center|Lumbini Eye Institute and Hospital|Bharatpur Eye Hospital|National Eye Institute (NEI) May 2010 Phase 3

Chemical lnformation & Solubility

Molecular Weight 665.73 Formula

C33H47NO13
CAS No. 7681-93-8 SDF Download Natamycin SDF
Smiles CC1CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC3C(O3)C=CC(=O)O1)O)O)O)C(=O)O)OC4C(C(C(C(O4)C)O)N)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 10 mg/mL ( (15.02 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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