Home Endocrinology & Hormones Glucocorticoid Receptor agonist - Immunology & Inflammation related inhibitor Prednisone For research use only.

Prednisone

Synonyms: Adasone,NSC-10023

Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

Prednisone Chemical Structure

Prednisone Chemical Structure

CAS: 53-03-2

Selleck's Prednisone has been cited by 6 publications

Purity & Quality Control

Batch: Purity: 99.91%
99.91

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Biological Activity

Description Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
Targets
Glucocorticoid receptor [1]
In vitro
In vitro Prednisone blocks Peripheral blood lymphocytes (PBL) growth in the G1 phase of cell cycle and inhibits both IL-2 receptor (IL-2R) expression and IL-2 secretion in activated human peripheral blood T lymphocytes. Prednisone increases apoptosis in PHA-activated human PBL, and the apoptotic effect of Prednisone is stronger on CD8(+) than on CD4(+) T lymphocytes. [1]
In Vivo
In vivo Prednisone-treated rats show a significant delay of 20% in learning and memory retention in rats as compared with controls. [2] Prednisone results in reduced weight gain, unchanged alter uterine weight, lowered serum magnesium (Mg), unchange serum calcium (Ca), phosphate (P), 25-hydroxyvitamin D (25OHD), or 1,25-dihydroxyvitamin D [1,25(OH)2D], striking increased in calcified cartilage, reduced cross-sectional area and cortical area, unchange medullary area of the tibial diaphysis, lowered periosteal and endocortical bone formation and apposition rates, increased mean cancellous bone area and cancellous bone perimeter of the tibial metaphysis in both sham-operated and ovariectomized rats. [3] Prednisone-treated rabbit shows a 30% reduction in percent stenosis, a 35% decrease in neointimal area, and a 66% decrement in neointimal thickness. [4] Prednisone treatment significantly reduces the level of TGF-beta1 and HYP in diaphragm from mdx mice to values similar to control mice, but results in a higher level of the HP cross-link compared with untreated mdx mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05669014 Recruiting Idiopathic Inflammatory Myositis Horizon Therapeutics Ireland DAC|Horizon Pharma Ireland Ltd. Dublin Ireland December 4 2023 Phase 2
NCT06037811 Not yet recruiting Inflammatory Arthritis|Immune-related Adverse Event Tom Appleton|Canadian Research Group in Immuno-Oncology|Western University|Lawson Health Research Institute November 2023 Phase 2
NCT06119529 Not yet recruiting Healthy|Atopic Dermatitis Eli Lilly and Company November 1 2023 Phase 1
NCT06079788 Recruiting Nephrotic Syndrome in Children Mao Jianhua|Tongji Hospital|Children''s Hospital affiliated to Capital Institute of Pediatrics|Xinhua Hospital Shanghai Jiao Tong University School of Medicine|Children''s Hospital of Nanjing Medical University|Kunming Children''s Hospital|Yuying Childrens Hospital of Wenzhou Medical University|Ningbo Women & Children''s Hospital|The Children''s Hospital of Zhejiang University School of Medicine November 1 2023 Phase 3
NCT06125405 Recruiting Nephrotic Syndrome in Children|Telitacicept The Children''s Hospital of Zhejiang University School of Medicine November 24 2023 Phase 3

Chemical lnformation & Solubility

Molecular Weight 358.43 Formula

C21H26O5
CAS No. 53-03-2 SDF Download Prednisone SDF
Smiles CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 71 mg/mL ( (198.08 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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