Home Neuronal Signaling AChR inhibitor Rocuronium Bromide For research use only.

Rocuronium Bromide

Synonyms: ORG 9426

Rocuronium Bromide (ORG 9426) is a competitive AchR antagonist, used in modern anaesthesia.

Rocuronium Bromide Chemical Structure

Rocuronium Bromide Chemical Structure

CAS: 119302-91-9

Purity & Quality Control

Batch: Purity: 99.78%
99.78

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Biological Activity

Description Rocuronium Bromide (ORG 9426) is a competitive AchR antagonist, used in modern anaesthesia.
Targets
AChR [1]
In vitro
In vitro Rocuronium bromide (RB), an aminosteroid type neuromuscular blocking agent, acts by reducing or inhibiting the depolarising effect of acetylcholine on the terminal disc of the muscle cell. [1] Rocuronium interacts with human liver microsomal cytochromes P450 (CYP) by binding to the substrate site. Rocuronium has caused inhibition of both reactions by 20 and 15%, respectively. [2]
In Vivo
In vivo Rocuronium is an ideal muscle relaxant with a rapid onset, intermediate duration of action, nondepolarizing properties and lack of cardiovascular side effects. Rocuronium produces a dose-dependent duration of neuromuscular blockade in isoflurane anesthetized horses. [3] Rocuronium bromide, is a relatively low potency, intermediate-acting agent with a rapid onset time of 98 seconds in dogs. [4] Rocuronium is an effective nondepolarizing muscle relaxant in the cat under the clinical conditions of this study. Rocuronium has a rapid onset, a short duration of action. [5] Rocuronium (0.6 mg/kg) results in a significant increase in heart rate one min after IV administration in the dog. Rocuronium (0.3 mg/kg and 0.6 mg/kg) produce a reliable neuromuscular block of 23–32 min duration, respectively. [6] Rocuronium bromide paralyzes the internal laryngeal muscles keeping the vocal cords in an intermediate position (paramedial) 60 seconds after being administered in cats. [7]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05619848 Completed Spinal Stenosis Lumbar Zheng Guo|Second Hospital of Shanxi Medical University October 25 2022 Early Phase 1
NCT00675792 Completed Anesthesia Merck Sharp & Dohme LLC May 2008 Phase 3

Chemical lnformation & Solubility

Molecular Weight 609.68 Formula

C32H53N2O4.Br
CAS No. 119302-91-9 SDF Download Rocuronium Bromide SDF
Smiles CC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C.[Br-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 122 mg/mL ( (200.1 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 122 mg/mL

Ethanol : 122 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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