Home Metabolism Retinoid Receptor agonist Tazarotene For research use only.

Tazarotene

Synonyms: AGN190168

Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.

Tazarotene Chemical Structure

Tazarotene Chemical Structure

CAS: 118292-40-3

Selleck's Tazarotene has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.98%
99.98

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Biological Activity

Description Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.
Targets
RAR [1]
In vitro
In vitro Tazarotene causes ERK activation, RB tumor suppressor protein hypophosphorylation, G0 arrest, and myeloid differentiation in HL-60 human myeloblastic leukemia cells. Tazarotene could propel either early or late portions of the period leading to differentiation and G0 arrest and is interchangeable with an RARalpha-selective ligand. [1] Tazarotene therapy regulates gene transcription via interaction with specific nuclear retinoic acid receptors (RARs), thereby modulating the three key pathogenic factors in psoriasis. [2] Tazarotene inhibits the proliferation of fibroblasts and synthesis of DNA and collagen. [3] Tazarotene down-regulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation. Tazarotene also up-regulates three novel genes TIG-1 (tazarotene-induced gene-1), TIG-2, and TIG-3, which may mediate an antiproliferative effect. [4] Tazarotene causes growth suppression in retinoid-responsive breast cancer cell lines by up-regulating TIG3. [5]
In Vivo
In vivo Tazarotene treatment reduces the number and size of microscopic basal cell carcinomas (BCCs) in UV-treated Ptch1+/− mice. Tazarotene treatment reduces the number and size of microscopic basal cell carcinomas (BCCs) in ionizing radiation-treated Ptch1+/− mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06015152 Completed Scalp Psoriasis Jinnah Postgraduate Medical Centre August 1 2022 Not Applicable
NCT03988439 Recruiting Psoriasis Bausch Health Americas Inc. March 24 2021 Phase 4
NCT02620813 Completed Acne Vulgaris University of California Davis October 2015 Early Phase 1

Chemical lnformation & Solubility

Molecular Weight 351.46 Formula

C21H21NO2S
CAS No. 118292-40-3 SDF Download Tazarotene SDF
Smiles CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 10 mg/mL ( (28.45 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


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In vivo
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