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Teicoplanin

Synonyms: Teichomycin,Targocid,MDL-507

Teicoplanin (Teichomycin,Targocid,MDL-507) is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.

Teicoplanin Chemical Structure

Teicoplanin Chemical Structure

CAS: 61036-62-2

Selleck's Teicoplanin has been cited by 4 publications

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Biological Activity

Description Teicoplanin (Teichomycin,Targocid,MDL-507) is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.
In vitro
In vitro

Teicoplanin is associated with small increases in the GI colonization by C. albicans. [1] The inhibitory action of Teicoplanin on proteoglycan polymerization but not on nucleic acid and protein synthesis indicates that the effect in the wall is due to the accumulation at this level of proteoglycan soluble precursors continuously produced by the cell. [2] Teicoplanin, at a concentration of 1 mg/mL, causes rapid lysis of exponential phase cells of Streptococcus faecalis. [3] Teicoplanin inhibits peptidoglycan synthesis in intact cells and in cell-free systems. Teicoplanin-induced lysis is dependent on the growth phase of B. pumilus at the time of addition of the antibiotic. Teicoplanin induces lysis after a longer lag phase with slowly growing Strep. jhecalis CCM 1875 and lysis is not very extensive. [4]
In Vivo
In vivo

Teicoplanin therapy increases the survival rate whereas G-CSF therapy does not in comparison to other groups in neutropenic mice. Teicoplanin and G-CSF combination therapy improves survival rate when compared with groups II, III, IV. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03909698 Completed Kidney Failure Chronic|Antibiotics|Hemodialysis University Hospital Ghent|University Ghent September 15 2016 --
NCT03229135 Completed Pneumonia Gram-Positive Bacterial People''s Hospital of Zhengzhou University February 1 2015 --
NCT03177369 Completed Teicoplanin-based Antimicrobial Therapy|Staphylococcus Aureus|Bone and Joint Infection Hospices Civils de Lyon January 2015 --
NCT01324804 Unknown status Coronary Heart Disease|Surgical Wound Infection Medical University of Vienna November 2010 --
NCT00754273 Completed Methicillin-resistant Staphylococcal Aureus Pneumonia University of Kentucky|Pfizer September 2008 --

Chemical lnformation & Solubility

Molecular Weight 1709.39 Formula

C77H77N9O31Cl2·R
CAS No. 61036-62-2 SDF Download Teicoplanin SDF
Smiles CCCCCCCCCC(=O)NC1C(C(C(OC1OC2=C3C=C4C=C2OC5=C(C=C(C=C5)C(C6C(=O)NC(C7=C(C(=CC(=C7)O)OC8C(C(C(C(O8)CO)O)O)O)C9=C(C=CC(=C9)C(C(=O)N6)NC(=O)C4NC(=O)C1C2=CC(=CC(=C2)OC2=C(C=CC(=C2)C(C(=O)NC(CC2=CC(=C(O3)C=C2)Cl)C(=O)N1)N)O)O)O)C(=O)O)OC1C(C(C(C(O1)CO)O)O)NC(=O)C)Cl)CO)O)O
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