Home Transmembrane Transporters Chloride Channel inhibitor Torsemide For research use only.

Torsemide

Synonyms: AC-4464, JDL-464

Torsemide (AC-4464, JDL-464) is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.

Torsemide Chemical Structure

Torsemide Chemical Structure

CAS: 56211-40-6

Selleck's Torsemide has been cited by 1 publication

Purity & Quality Control

Batch: S169801 4-Methylpyridine] 30 mg/mL] true] DMSO] 1 mg/mL] false] Water] Insoluble] false Purity: 100%
100

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Biological Activity

Description Torsemide (AC-4464, JDL-464) is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.
Targets
Cl- channel [1]
In vitro
In vitro Torsemide inhibits aldosterone secretion by adrenal cells from rats, cows, and guinea pigs stimulated in vitro by potassium, angiotensin, dibutyryl cyclic AMP, ACTH, or corticosterone. [1] Torsemide's primary site of action is the thick ascending loop of Henle in the nephron, where it promotes excretion of sodium, water, and chloride via interaction with the Na+, K+, 2Cl− cotransporter. Torsemide interferes with the secretion of, and receptor ligand binding of, the mineralocorticoid aldosterone in a dose-dependent manner. [2]
In Vivo
In vivo Torsemide results in elevated levels of circulating angiotensin II and aldosterone (supportive of interference with aldosterone at the receptor level) in dogs with experimental mitral regurgitation whereas furosemide results in elevated levels of angiotensin II, only. [2] Torsemide increases the BUN and plasma creatinine concentrations in rats, compared with the baseline value. Torsemide immediately increases urine volume significantly. [3]

Chemical lnformation & Solubility

Molecular Weight 348.42 Formula

C16H20N4O3S
CAS No. 56211-40-6 SDF Download Torsemide SDF
Smiles CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C
Storage (From the date of receipt)

In vitro
Batch:

4-Methylpyridine : 30 mg/mL

DMSO : 1 mg/mL ( (2.87 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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