Home Immunology & Inflammation Immunology & Inflammation related inhibitor Bestatin (Ubenimex) For research use only.

Bestatin (Ubenimex)

Synonyms: NK421

Bestatin (Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.

Bestatin (Ubenimex) Chemical Structure

Bestatin (Ubenimex) Chemical Structure

CAS: 58970-76-6

Selleck's Bestatin (Ubenimex) has been cited by 6 Publications

1 Customer Review

Purity & Quality Control

Batch: Purity: 99.87%
99.87

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Biological Activity

Description Bestatin (Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.
Targets
Aminopeptidase-N [6]
In vitro
In vitro

Bestatin inhibits proliferation of all the human leukemic cell lines except KG1. Bestatin induces DNA fragmentation quantitatively and DNA ladder and enhances caspase-3 activity in U937 cells. Bestatin dose-dependently induces DNA fragmentation in human leukemic cell lines. [1] Bestatin dose-dependently inhibits the invasion of SN12M cells into reconstituted basement membrane (Matrigel). Bestatin inhibits the degradation of type IV collagen by tumor cells, but not by tumor-conditioned medium (TCM), in a concentration-dependent manner. Bestatin inhibits hydrolysing activities towards substrates of aminopeptidases in SN12M cells. [2] Bestatin inhibits the tube-like formation of human umbilical vein endothelial cells (HUVECs) in vitro. [3] Bestatin exerts a direct stimulating effect on lymphocytes (and monocytes) via its fixation on cell surface leucine-aminopeptidase, and an indirect effect on monocytes (and lymphocytes) via aminopeptidase B inhibition of tuftsin catabolism. [4]
In Vivo
In vivo

Bestatin significantly inhibits the melanoma cell-induced angiogenesis in a mouse dorsal air sac assay. Bestatin reduces the number of vessels oriented towards the established primary tumor mass on the dorsal side of mice implantated of B16-BL6 melanoma cells. [3] Bestatin statistically significantly inhibits leukotriene B4 biosynthesis in the esophageal tissues of EGDA rats and reduces the incidence of EAC in the EGDA rats from 57.7% (15 of 26 rats) to 26.1% (6 of 23 rats). [5]

Chemical lnformation & Solubility

Molecular Weight 308.37 Formula

C16H24N2O4
CAS No. 58970-76-6 SDF Download Bestatin (Ubenimex) SDF
Smiles CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 7 mg/mL ( (22.7 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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