Home Metabolism P450 (e.g. CYP17) chemical - Fungal chemical Voriconazole For research use only.

Voriconazole

Synonyms: UK-109496

Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol.

Voriconazole Chemical Structure

Voriconazole Chemical Structure

CAS: 137234-62-9

Selleck's Voriconazole has been cited by 25 Publications

1 Customer Review

Purity & Quality Control

Batch: Purity: 100%
100

Other P450 (e.g. CYP17) Products

Related compound libraries

Choose Selective P450 (e.g. CYP17) Inhibitors

Biological Activity

Description Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol.
Targets
P450 [1]
In vitro
In vitro

Voriconazole is active against certain opportunistic filamentous and dimorphic fungi (molds) and yeasts. Voriconazole in vitro activities are higher than or similar to those of itraconazole and amphotericin B for most of the molds tested, with the exceptions of R. arrhizus and S. schenckii. [1] Voriconazole inhibits 95% of isolates at ≤1 μg/ml against 448 recent clinical mold isolates. [2]
In Vivo
In vivo

Voriconazole is significantly more effective than itraconazole in reducing Aspergillus content in the lungs of immunocompromised guinea pig with pulmonary aspergillosis. Voriconazole also has been shown to be effective in guinea pigs with experimental pulmonary or intracranial infections caused by C. neoformans. [1] Voriconazole (5 mg/kg/day, i.p.) combined with Amphotericin B (1.25 mg/kg/day, i.p.) significantly reduces the colony counts in the tissues of selected Guinea pigs compared with those in the tissues of the controls. Voriconazole (5 mg/kg/day, i.p.) combined with Amphotericin B (1.25 mg/kg/day, i.p.) also results in reductions in colony counts in tissues compared with those in the tissues of Guinea pigs treated with caspofungin acetate (the difference is not statistically significant) and improves the survival times but does not sterilize tissues. Voriconazole (5 mg/kg/day, i.p.) combined with caspofungin acetate (CAS) at either dose reduces colony counts in tissues 1,000-fold over those for the controls and are the only regimens that significantly reduces the numbers of positive cultures. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04865419 Terminated Haematological Malignancies AstraZeneca June 11 2021 Phase 1|Phase 2
NCT04824417 Recruiting Chronic Pulmonary Aspergillosis Postgraduate Institute of Medical Education and Research March 1 2021 Phase 3
NCT04229303 Completed Allergic Bronchopulmonary Aspergillosis Zambon SpA February 11 2020 Phase 1
NCT04743544 Unknown status Adverse Drug Reactions Dokuz Eylul University|University of Liverpool November 1 2019 --

Chemical lnformation & Solubility

Molecular Weight 349.31 Formula

C16H14F3N5O
CAS No. 137234-62-9 SDF Download Voriconazole SDF
Smiles CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 70 mg/mL ( (200.39 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.

Frequently Asked Questions

Question 1:
I am trying to use voriconazole in vivo via ip injection. Is the formulation recommended on your website (2% DMSO+30% PEG 300+2% Tween 80+ddH2O) suitable for injection?

Answer:
S1442 can be dissolved in 2% DMSO+30% PEG 300+2% Tween 80+ddH2O at 8mg/ml clearly. When making the solution, please dissolve the compound in DMSO clearly first. Then add PEG and Tween, after they mixed well, then dilute with water.

P450 (e.g. CYP17) Signaling Pathway Map

Tags: buy Voriconazole | Voriconazole ic50 | Voriconazole price | Voriconazole cost | Voriconazole solubility dmso | Voriconazole purchase | Voriconazole manufacturer | Voriconazole research buy | Voriconazole order | Voriconazole mouse | Voriconazole chemical structure | Voriconazole mw | Voriconazole molecular weight | Voriconazole datasheet | Voriconazole supplier | Voriconazole in vitro | Voriconazole cell line | Voriconazole concentration | Voriconazole nmr