Home Neuronal Signaling Adrenergic Receptor agonist Xylazine HCl For research use only.

Xylazine HCl

Synonyms: BAY 1470 hydrochloride

Xylazine(BAY 1470 hydrochloride) is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.

Xylazine HCl Chemical Structure

Xylazine HCl Chemical Structure

CAS: 23076-35-9

Selleck's Xylazine HCl has been cited by 8 publications

Purity & Quality Control

Batch: Purity: 99.94%
99.94

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Biological Activity

Description Xylazine(BAY 1470 hydrochloride) is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.
Targets
α2-adrenergic receptor [1]
In Vivo
In vivo

Xylazine dose-dependently inhibits norepinephrine release and lipolysis in beagle dogs. Xylazine also tends to decrease epinephrine levels dose-dependently. [1] Xylazine hydrochloride dose- and time-dependently reduces amount of minimum alveolar concentration (MAC) in horse.  Xylazine hydrochloride dose- and time-dependently increases blood glucose concentration in horse. [2] Xylazine induces variable bilateral caudal analgesia extending from coccyx to S3, with minimal sedation, ataxia, and cardiovascular and respiratory depression in standing mares. Xylazine significantly decreases heart and respiratory rates, systolic, diastolic, and mean arterial blood pressure, PCV, hemoglobin concentration, arterial oxygen content, and oxygen transport. [3] Xylazine results in significantly decreased heart rate, increased incidence of atrioventricular block, and decreased cardiac output and cardiac index in horse. [4] Xylazine induces sedation and selective (S3 to Co) analgesia for at least 2 hours in cows. Xylazine significantly decreases heart rate, respiratory rate, rate of ruminal contractions, arterial blood pressure, PaO2, PCV, and total solids concentration, and significantly increases PaCO2, base excess, and bicarbonate concentration in cows. [5] Xylazine severely depresses the N3 field (-75%) and completely abolishes the climbing fiber field (-100%) in the nonanesthetized, decerebrated rat. Xylazine- ketamine injections also severely depresses the N3 field (-75%) and nearly completely abolishes theclimbing fiber field (-90%) in the nonanesthetized, decerebrated rat.[6]

Chemical lnformation & Solubility

Molecular Weight 256.79 Formula

C12H16N2S.HCl
CAS No. 23076-35-9 SDF Download Xylazine HCl SDF
Smiles CC1=C(C(=CC=C1)C)NC2=NCCCS2.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 51 mg/mL ( (198.6 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 51 mg/mL

Ethanol : 51 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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